Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations

Jackson, David J.; Gern, James E.

doi:10.1016/j.jaip.2022.01.006

Cited by 64 publications

(55 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously, this group was considered to be "common cold" viruses, yet recent human volunteer studies have shown that they may cause severe infections, especially in patients with underlying lung disease [1]. EV-HRVs are known to cause exacerbations of reactive airway disease in both children and adults [2], though more recently, they have been associated with ARDS [3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation of EV-HRV varies with many patients remaining asymptomatic or having mild upper respiratory tract symptoms such as nasal congestion, cough, and fatigue [ 1 ]. Wheezing and dyspnea may occur in patients with reactive airway disease, ranging from mild symptom exacerbation to near-fatal asthma exacerbations [ 2 ]. Patients with COPD may also experience wheezing and dyspnea, ranging from mild to severe [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical picture of EV-HRV infection may range from asymptomatic infection, cough and nasal congestion [1], wheezing and dyspnea [2,7,8], to hospitalization requiring supplemental oxygen [1,9], or much less commonly lead to fulminant respiratory failure requiring mechanical ventilation [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Enterovirus-human-rhinovirus (EV-HRV) is best known for its ability to cause upper respiratory tract illness and simple bronchitis [ 1 ]. Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are also well documented [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enterovirus-Human-Rhinovirus Infection Leading to Acute Respiratory Distress Syndrome: A Case Report

Cecchini¹,

Othman²,

Kaur³

et al. 2022

Cureus

View full text Add to dashboard Cite

Enterovirus-human-rhinovirus (EV-HRV) is best known to cause the "common cold" and asthma exacerbations. Simple bronchitis and community-acquired pneumonia related to EV-HRV are also well documented. Scattered reports of rhinovirus causing acute respiratory distress syndrome (ARDS) have been published, yet the causality between recent SARS-CoV-2 pneumonia and severe ARDS secondary to EV-HRV has not been well defined. This case presents a 67-year-old male who was unvaccinated against SARS-CoV-2 with a past medical history of chronic obstructive pulmonary disease, who recently experienced a mild-tomoderate case of SARS-CoV-2 pneumonia, which was treated with dexamethasone and remdesivir. He was discharged to an inpatient psychiatric facility on as-needed oxygen via nasal cannula. Three weeks later, he experienced an episode of presyncope and was readmitted to the hospital. He then began to require increasing levels of supplemental oxygen via a high-flow nasal cannula. A real-time polymerase chain reaction respiratory pathogen panel was positive for EV-HRV. Computed tomography of the chest revealed extensive ground-glass opacities. Further workup for bacterial and fungal pneumonia was negative. Repeat SARS-CoV-2 testing was also negative. He required several days of supplemental oxygen via a high-flow nasal cannula. He received a short course of broad-spectrum antibiotics and a 10-day course of high-dose dexamethasone. Ultimately, he fully recovered, did not require further supplemental oxygen, and was discharged on room air.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enterovirus-Human-Rhinovirus Infection Leading to Acute Respiratory Distress Syndrome: A Case Report

Cecchini¹,

Othman²,

Kaur³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Therefore, other confounding factors, such as respiratory virus type or peripheral blood eosinophilia or parental history of asthma/allergy, were not evaluated. Furthermore, the effectiveness of the systemic corticosteroids may not depend on the virus type per se but potentially on the eosinophilic airway inflammation, which is often present in atopic children and/or accompanied by a HRV-induced respiratory infection ( 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review

Ambrożej

Makrinioti²,

Whitehouse³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

It has become clear that severe bronchiolitis is a heterogeneous disease; even so, current bronchiolitis management guidelines rely on the one-size-fits-all approach regarding achieving both short-term and chronic outcomes. It has been speculated that the use of molecular markers could guide more effective pharmacological management and achieve the prevention of chronic respiratory sequelae. Existing data suggest that asthma-like treatment (systemic corticosteroids and beta2-agonists) in infants with rhinovirus-induced bronchiolitis is associated with improved short-term and chronic outcomes, but robust data is still lacking. We performed a systematic search of PubMed, Embase, Web of Science, and the Cochrane’s Library to identify eligible randomized controlled trials to determine the efficacy of a personalized, virus-dependent application of systemic corticosteroids in children with severe bronchiolitis. Twelve studies with heterogeneous methodology were included. The analysis of the available results comparing the respiratory syncytial virus (RSV)-positive and RSV-negative children did not reveal significant differences in the associatons between systemic corticosteroid use in acute episode and duration of hospitalization (short-term outcome). However, this systematic review identified a trend of the positive association between the use of systematic corticosteroids and duration of hospitalization in RSV-negative infants hospitalized with the first episode of bronchiolitis (two studies). This evidence is not conclusive. Taken together, we suggest the design for future studies to assess the respiratory virus type in guiding predictive enrichment approaches in infants presenting with the first episode of bronchiolitis.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42020173686

show abstract

Infant respiratory syncytial virus infection and childhood asthma: A shift in the paradigm?

Rosas‐Salazar,

Hartert

2023

Clinical & Translational Med

View full text Add to dashboard Cite

Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations

Cited by 64 publications

References 103 publications

Enterovirus-Human-Rhinovirus Infection Leading to Acute Respiratory Distress Syndrome: A Case Report

Enterovirus-Human-Rhinovirus Infection Leading to Acute Respiratory Distress Syndrome: A Case Report

Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review

Infant respiratory syncytial virus infection and childhood asthma: A shift in the paradigm?

Contact Info

Product

Resources

About