Rhinovirus illnesses during infancy predict subsequent childhood wheezing

Lemanske, Robert F.; Jackson, Daniel J.; Gangnon, Ronald E.; Evans, Michael D.; Li, Zhanhai; Shult, Peter; Kirk, Carol J.; Reisdorf, Erik; Roberg, K.A.; Anderson, Elizabeth; Carlson-Dakes, K.; Adler, Kiva J.; Gilbertson‐White, Stephanie; Pappas, T.E.; DaSilva, D.F.; Tisler, C.J.; Gern, James E.

doi:10.1016/j.jaci.2005.06.024

Cited by 666 publications

(642 citation statements)

References 33 publications

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“…The synergistic interaction between viral infections, most commonly RV, and sensitization to aeroallergens during early life has also been linked to the risk of developing asthma later in life in term-born children [101,103 104,112…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…It is now well established that children who experience human rhinovirus (HRV)-induced wheezing illnesses in early life are at increased risk of subsequently developing asthma (10,11), particularly if they are also sensitized to inhaled allergens (12). Pre-school age children have been shown to experience approximately six HRV infections each year (13), and serial HRV infections can cause recurrent wheezing episodes (14).…”

Section: Introductionmentioning

confidence: 99%

Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration

Shariff

Shelfoon

Holden

et al. 2017

Am J Respir Cell Mol Biol

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Rationale: Airway remodeling, a characteristic feature of asthma, begins in early life. Recurrent human rhinovirus (HRV) infections are a potential inciting stimulus for remodeling. One component of airway remodeling is an increase in airway smooth muscle cell mass with a greater proximity of the airway smooth muscle cells (ASMC) to the airway epithelium. We asked whether human bronchial epithelial cells infected with HRV produced mediators that are chemotactic for ASMC.Methods: ASMC migration was investigated using the modified Boyden Chamber and the xCELLigence Real-Time Cell Analyzer. Multiplex bead analysis was used to measure HRVinduced epithelial chemokine release. The chemotactic effects of CCL5, CXCL8 and CXCL10 were also examined.Results: Supernatants from HRV-infected epithelial cells caused ASMC chemotaxis. Pretreatment of ASMC with pertussis toxin abrogated chemotaxis, as did treatment with formoterol, forskolin, or 8-bromo-cAMP. CCL5, CXCL8, and CXCL10 were most up-regulated chemokines produced by HRV-infected airway epithelial cells. When recombinant CCL5, CXCL8 and CXCL10 were used at levels found in epithelial supernatants they induced ASMC chemotaxis similar to that seen with epithelial cell supernatants. When examined individually, CCL5 was the most effective chemokine in causing ASMC migration and treatment of supernatant from HRVinfected epithelial cells with anti-CCL5 antibodies significantly attenuated ASMC migration. Conclusion:These findings suggest that HRV-induced CCL5 can induce ASMC chemotaxis, and thus may contribute to the pathogenesis of airway remodeling in asthmatic patients.3

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“…Human rhinovirus (HRV) is 1 of the most common agents associated with upper and lower respiratory tract infections in children and infants ( 1 ) and is a major trigger of asthma exacerbations ( 2 ). Recently, molecular methods have shown substantial phenotypic variation of HRV and identified a novel HRV genogroup provisionally named HRV-C ( 3 ).…”

mentioning

confidence: 99%