Rhinophototherapy in persistent allergic rhinitis

Bella, Zsolt; Kiricsi, Ágnes; Viharosné, Éva Dósa-Rácz; Dallos, Attila; Perényi, Ádám; Kiss, Mária; Koreck, Andrea; Kemény, Lajos; Jóri, József; Rovó, László; Kadocsa, Edit

doi:10.1007/s00405-016-4358-x

Cited by 14 publications

(20 citation statements)

References 25 publications

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“…A number of researchers believe that a variety of inflammatory mediators may play important roles in the pathogenesis of allergic rhinitis (19), such as IL-17A and IL-6. As an important member of the IL-17 family, IL-17A could induce the activation of T cells, activate protein kinases, regulate the activity of kinases, play an important role in signaling pathways (such as P38-mitogen-activated protein kinase), and stimulate the release of various inflammatory factors, such as IL-6 and IL-8, thereby triggering a series of inflammatory airway response (9).…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Gao

Zhang³

et al. 2021

Ann Palliat Med

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Background: Allergic rhinitis is a chronic inflammatory disease with a high incidence, affecting the quality of life of patients. The aim of the present study was to explore the expression and clinical significance of vascular endothelial cell adhesion molecule-1 (VCAM-1), interleukin (IL)-6, and IL-17A in patients with allergic rhinitis.Methods: A total of 180 patients with allergic rhinitis, who were admitted to our hospital from March 2017 to March 2020, were enrolled as the observation group. Patients were further divided into 3 subgroups according to the degree of severity of allergic rhinitis as follows: the mild group (n=66), the moderate group (n=60), and the severe group (n=54). During the same period, 188 people without allergic rhinitis, who underwent physical examination in our hospital, were enrolled as the control group. VCAM-1, IL-6, and IL-17A levels were compared between these groups, and the correlation between the 3 levels and allergic rhinitis was analyzed.Results: VCAM-1, IL-6, and IL-17A levels in the observation group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). Comparison results of VCAM-1, IL-6 and IL-17A levels among the 3 groups were as follows: mild group < moderate group < severe group, and the differences between the three groups were significant (P<0.05). Pearson linear correlation showed that serum levels of VCAM-1, IL-6 and IL-17A were positively correlated with ARIA (P<0.05). Parent history of allergic rhinitis, living environment pollution, abnormally elevated VCAM-1, abnormally elevated IL-6 and abnormally elevated IL-6 were the related risk factors for inducing allergic rhinitis (P<0.05).Conclusions: VCAM-1, IL-6, and IL-17A play important roles in allergic rhinitis, and the concentration will increase with disease progression. Clinical testing of VCAM-1, IL-6, IL-17A should be increased to improve the diagnostic rate for early allergic rhinitis and to prevent disease progression.

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Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Gao

Zhang³

et al. 2021

Ann Palliat Med

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“…It has been reported that intranasal irradiation using Rhinolight (Rhinolight Ltd., Szeged, Hungary), which contains visible light (70%), UVA (25%) and UVB (5%) was effective for AR treatment 19,20 . It has also been reported that Rhinolight induced apoptosis of T cells and eosinophils in the nasal mucosa, and decreased levels of IL‐5 and eosinophilic cationic protein in the nasal discharge 19 .…”

Section: Discussionmentioning

confidence: 99%

Effects of narrow‐band UVB on nasal symptom and upregulation of histamine H₁ receptor mRNA in allergic rhinitis model rats

Kamimura

Kitamura

Fujii

et al. 2021

Laryngoscope Investig Oto

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Background Phototherapy with narrow‐band ultraviolet B (narrow‐band UVB) is clinically effective treatment for atopic dermatitis. In the present study, we examined the effects of intranasal irradiation with narrow‐band UVB on nasal symptom, upregulation of histamine H1 receptor (H1R) gene expression and induction of DNA damage in the nasal mucosa of allergic rhinitis (AR) model rat. Methods AR model rats were intranasally irradiated with 310 nm of narrow‐band UVB. Nasal mucosal levels of H1R mRNA were measured using real‐time quantitative reverse transcriptase (RT)‐PCR. DNA damage was evaluated using cyclobutane pyrimidine dimer (CPD) immunostaining. Results In toluene 2,4‐diisocyanate (TDI)‐sensitized rats, TDI provoked sneezes and H1R gene expression in the nasal mucosa. Intranasal pre‐irradiation with 310 nm narrow‐band UVB at doses of 600 and 1400, but not 200 mJ/cm2 significantly inhibited the number of sneezes and upregulation of H1R gene expression provoked by TDI. CPD‐positive cells appeared in the nasal mucosa after intranasal narrow‐band UVB irradiation at a dose of 1400, but not 200 and 600 mJ/cm2. The suppression of TDI‐provoked sneezes and upregulation of H1R gene expression lasted 24 hours, but not 48 hours, after narrow‐band UVB irradiation with a dose of 600 mJ/cm2. Conclusions Intranasal pre‐irradiation with narrow‐band UVB dose‐dependently inhibited sneezes and upregulation of H1R gene expression of the nasal mucosa in AR model rats, suggesting that the inhibition of nasal upregulation of H1R gene expression suppressed nasal symptom. The suppression after narrow‐band UVB irradiation at a dose of 600 mJ/cm2 was reversible without induction of DNA damage. These findings indicated that low‐dose narrow‐band UVB phototherapy could be effectively and safely used for AR treatment in a clinical setting. Level of Evidence NA.

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“…Devices beaming inside the nose certain wavelengths of visible and infrared light have been shown to reduce the symptoms and improve HRQoLin subjects with allergic rhinitis to both outdoor and indoor allergens. 187 , 188 , 189 , 190 …”

Section: Devices Used For Treatmentmentioning

confidence: 99%

Medical devices in allergy practice

Popov

Passalacqua

González‐Díaz

et al. 2020

World Allergy Organization Journal

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Medical devices provide people with some health benefits in terms of diagnosis, prevention, treatment, and monitoring of disease processes. Different medical specialties use varieties of medical devices more or less specific for them. Allergology is an interdisciplinary field of medical science and teaches that allergic reactions are of systemic nature but can express themselves at the level of different organs across the life cycle of an individual. Subsequently, medical devices used in allergology could be regarded as: 1) general, servicing the integral diagnostic and management principles and features of allergology, and 2) organ specific, which are shared by organ specific disciplines like pulmonology, otorhinolaryngology, dermatology, and others. The present position paper of the World Allergy Organization (WAO) is meant to be the first integral document providing structured information on medical devices in allergology used in daily routine but also needed for sophisticated diagnostic purposes and modern disease management. It is supposed to contribute to the transformation of the health care system into integrated care pathways for interrelated comorbidities.

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Rhinophototherapy in persistent allergic rhinitis

Cited by 14 publications

References 25 publications

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Effects of narrow‐band UVB on nasal symptom and upregulation of histamine H₁ receptor mRNA in allergic rhinitis model rats

Medical devices in allergy practice

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Rhinophototherapy in persistent allergic rhinitis

Cited by 14 publications

References 25 publications

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis

Effects of narrow‐band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats

Medical devices in allergy practice

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Product

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Effects of narrow‐band UVB on nasal symptom and upregulation of histamine H₁ receptor mRNA in allergic rhinitis model rats