Rhinocerebral Mucormycosis in a Child With Acute Lymphoblastic Leukemia

Popa, G; Blag, Cristina; Sasca, Florina

doi:10.1097/mph.0b013e31815c255f

Cited by 14 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most reports of mucormycosis are of isolated cases, and there are few cases series in the literature. HM is the major underlying disease in these patients …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Bonifáz¹,

Tirado‐Sánchez²,

Calderón³

et al. 2014

Mycoses

View full text Add to dashboard Cite

SummaryWe present a single-centre, retrospective study of 22 cases of mucormycosis in children. A total of 158 mucormycosis cases were identified, of which 22 (13.96%) were children. The mean age of the children was 10.3 years (range: 6 months-18 years), and 59% of the infections occurred in males. The rhinocerebral form was the main clinical presentation (77.27%), followed by the primary cutaneous and pulmonary patterns. The major underlying predisposing factors were diabetes mellitus in 68.18% of the patients and haematologic diseases in 27.7% of the patients. The cases were diagnosed by mycological tests, with positive cultures in 95.4% of the patients. Rhizopus arrhizus was the foremost aetiologic agent in 13/22 cases (59.1%). In 21 cultures, the aetiologic agents were identified morphologically and by molecular identification. In 10 cultures, the internal transcribed spacer region of the ribosomal DNA was sequenced. Clinical cure and mycological cure were achieved in 27.3% cases, which were managed with amphotericin B deoxycholate and by treatment of the underlying conditions.

show abstract

“…Most reports of mucormycosis are of isolated cases, and there are few cases series in the literature. HM is the major underlying disease in these patients …”

Section: Discussionmentioning

confidence: 99%

“…HM is the major underlying disease in these patients. [12][13][14][15][16][17][18] This study examines the paediatric mucormycosis cases of a larger cases series at a single centre. Of the 158 confirmed cases of mucormycosis, 14% were children.…”

Section: Discussionmentioning

confidence: 99%

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Bonifáz¹,

Tirado‐Sánchez²,

Calderón³

et al. 2014

Mycoses

View full text Add to dashboard Cite

show abstract

“…17 Characteristic histological findings are irregular, broad, non-septate, twisted, ribbon-like, fungal hyphae with the right angle branching. 3,9,18 Fast identification of fungi in frozen sections is available with fluorescent microscopic stain using calcofluor white. 19 Regardless of the tissue or organ involved, pathological hallmarks of mucormycosis include invasion of blood vessels with occlusion causing subsequent tissue reaction of thrombosis, ischemia, and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Combined Medical and Surgical Management of Mucormycosis Results in Disease Eradication in 2 Pediatric Patients

2017

View full text Add to dashboard Cite

Rhinocerebral mucormycosis is an acute, rapidly fatal, fungal infection, classically involving the nasal mucosa and paranasal sinuses. It is an aggressive, opportunistic infection that frequently progresses to involve the orbit and cerebrum. Cerebral extension in immunocompromised patients is almost universally fatal. There are limited data on mucormycosis in pediatric immunocompromised patients in the literature, with only few reports on rhinocerebral involvement. The immunocompromised patients described in this report presented with suspected periorbital and nasal cellulitis, progressing rapidly to necrotic changes in nasal tissue and oral palatal mucosa. In these patients, the surgical resection of mucormycosis-infected tissue followed by flap reconstruction combined with medical treatment effectively treated the infection, allowed for the rapid resumption of chemotherapy and dramatically improved the quality of life for both the patient and their family.

show abstract

“… 4 Other single-center pediatric cases have recently been described, including a seven-year-old girl with ALL and rhino-cerebral mucormycosis, two children with acute leukemia and intraoral mucormycosis and four children with ALL and cutaneous mucormycosis; all patients were successfully treated with amphotericin B and surgical debridement. 5-8 Further case reports describe a child with acute leukemia and isolated muscular mucormycosis, one with ALL and fatal gastrointestinal mucormycosis, a nine-year-old boy with ALL and isolated hepatic mucormycosis requiring surgical excision and combined liposomal amphotericin B and posaconazole therapy. Wehl et al reported a boy with ALL relapse experiencing rhino-cerebral-mucormycosis who could not receive surgical debridement because of extensive involvement; his long-term survival of fifteen months was attributed to the long-term administration of liposomal amphotericin B, early neutrophil recovery and slow leukemia progression.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Rhino-Ocular-Cerebral Mucormycosis in a Leukemic Child: A Case Report and Review of Pediatric Literature

et al. 2015

View full text Add to dashboard Cite

Mucormycosis is an uncommon but severe fungal infection, typically observed in immunocompromized patients. We report a case of acute lymphoblastic leukemia complicated by rhino-oculo-cerebral mucormycosis in a pediatric patient. Combination lipid polyene-echinocandin therapy, along with surgical debridement appeared to be effective. Nevertheless, a severe relapse occurred during posaconazole prophylaxis; antifungal therapy, hemimaxillectomy and suspension of chemotherapy were performed. Although mucormycosis is a frequently lethal infection, prompt diagnosis and aggressive treatment can be successful even in cases of relapse.

show abstract

Rhinocerebral Mucormycosis in a Child With Acute Lymphoblastic Leukemia

Abstract: Rhinocerebral mucormycosis in acute lymphoblastic leukemia is manageable with sequential therapy including, amphotericin B, surgery, and risk-adapted chemotherapy.

Cited by 14 publications

References 10 publications

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Aggressive Combined Medical and Surgical Management of Mucormycosis Results in Disease Eradication in 2 Pediatric Patients

Recurrent Rhino-Ocular-Cerebral Mucormycosis in a Leukemic Child: A Case Report and Review of Pediatric Literature

Contact Info

Product

Resources

About