Rhinocerebral mucormycosis: a systematic review of case reports and case series from a global perspective

Kumar, Mathangi; Alagarsamy, Ragavi; Madi, Medhini; Pentapati, Kalyana Chakravarthy; Vineetha, Ravindranath; Shetty, Shishir Ram; Sharma, A.

doi:10.1016/j.oooo.2022.06.006

Cited by 5 publications

(15 citation statements)

References 44 publications

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“…Most of them are based on expert opinion consensus or studies with scarce evidence. 16 In any case, the treatment of these fungal infections will depend on the severity of the infection and the overall health of the patient. Treatment may include antifungal medications, such as amphotericin B, fluconazole, or itraconazole, and may require surgical interventions to remove infected tissue.…”

Section: Discussionmentioning

confidence: 99%

Coinfecciones emergentes: la intersección de mucormicosis, paracoccidioidomicosis y COVID-19

Vallejo Rodas,

Téliz Meneses,

Mendoza Álvarez

et al. 2023

Lat Am J Oral Maxillofac Surgi

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Section: Discussionmentioning

confidence: 99%

Coinfecciones emergentes: la intersección de mucormicosis, paracoccidioidomicosis y COVID-19

Vallejo Rodas,

Téliz Meneses,

Mendoza Álvarez

et al. 2023

Lat Am J Oral Maxillofac Surgi

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“…Common primary extra-oral signs of infection include headache, sinus pa tion, and bloody nasal discharge [9]. Other signs can also appear, such as fever and swelling, cephalea, and trigeminal and facial nerve paralysis [3]. Mucormycosis has a rapid progression and an incubation period that is tablished, depending on the patient's risk factors; therefore, rapid recognition o symptoms is crucial.…”

Section: Introductionmentioning

confidence: 99%

“…However, these clinical signs cannot provide a definitive diagnosis of muc therefore, a histological diagnosis is needed, where mucorales appear as hyalin in the form of strips and hyphae with variable diameters [5,6]. Usually it can the hematoxylin-eosin stain (H-E) (Figure 2), but if there are fewer samples or tration in the sample is low, calcofluor white is used, which makes it easier to Even so, there are cases where the diagnosis is unclear, and polymerase cha (PCR) is used to detect fungal DNA up to 3 days earlier than histopathologica [3]. Common primary extra-oral signs of infection include headache, sinus pain, congestion, and bloody nasal discharge [9].…”

Section: Introductionmentioning

confidence: 99%

“…Usually it can be seen in the hematoxylin-eosin stain (H-E) (Figure 2), but if there are fewer samples or its concentration in the sample is low, calcofluor white is used, which makes it easier to observe [6]. Even so, there are cases where the diagnosis is unclear, and polymerase chain reaction (PCR) is used to detect fungal DNA up to 3 days earlier than histopathological diagnosis [3]. There are four critical factors for adequate treatment: early diagnosis, control of underlying predisposing factors, extensive surgical debridement with margins of healthy tissue, and appropriate antifungal therapy [2].…”

Section: Introductionmentioning

confidence: 99%

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Oral Manifestations of Mucormycosis: A Systematic Review

Mora-Martínez,

Murcia,

Rodríguez-Lozano

2023

JoF

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Mucormycosis is a rare, opportunistic, and emerging fungal infection that can rapidly develop into a severe, highly fatal clinical picture. In most cases, it is caused by fungi of the order Mucorales, which are usually avirulent but become pathogenic when the host’s immune system is compromised. This systematic review was conducted according to PRISMA guidelines. The databases searched included PubMed, Scopus, and Web of Science. We chose articles that analyzed the oral manifestations of patients with mucormycosis, were published between 2018 and 2023, and met our search terms. The risk of bias in the articles was assessed using the CARE guideline for case reports and STROBE for a cross-sectional study. After the selection process, 20 articles were included in this review, all containing information about the different oral manifestations presented by people with mucormycosis. The most common oral manifestations are mainly bone exposures and oral ulcers, halitosis, pus discharge, gingival thickening, and periodontitis. However, despite the importance of recognizing these oral manifestations in the early stages of mucormycotic infection, providing early treatment, and reducing the high mortality rate of the infection, more studies are needed.

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“…The virus enters target cells through the interaction between the spike protein (S protein) and the ACE2 receptor [6,9], and TMPRSS2 plays a priming role in this process [5]. Therefore, this specific tropism manifests through the development of oral cavity pathologies [10][11][12] and other maxillofacial conditions, such as the wellknown association with mucormycosis [13,14]. Indeed, during SARS-CoV-2 infection, the oral mucosa can serve as a potential route for the virus, and regional pathologies in the oral cavity may arise [15][16][17].…”

mentioning

confidence: 99%

COVID-19 and Oral Lichen Planus: Between an “Intriguing Plot” and the “Fata Morgana Effect”

Scotto

Fazio

Massa

et al. 2023

JCM

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The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant morbidity and mortality worldwide since its declaration as a global pandemic in March 2020. Alongside the typical respiratory symptoms, unusual clinical manifestations such as oral lichen planus (OLP) have been observed. OLP is a chronic inflammatory mucocutaneous dermatosis that results from a cell-mediated reaction, and its pathogenesis involves the loss of immunological tolerance. OLP has been associated with several triggering factors, such as certain drugs, stress, smoking, and even some viruses. Exposure to the spike protein antigen of SARS-CoV-2 during an infection can trigger autoimmune reactions and lead to the onset or flare of OLP. The E3 protein ligase TRIM21, which is identified in the lamina propria of OLP lesions, is overexpressed in COVID-19 patients and plays a critical role in autoimmune pathologies. Furthermore, the psychological stress of the lockdown and quarantine can be a trigger for the onset or exacerbation of OLP. However, the diagnosis of OLP is complex and requires a biopsy in order to confirm a clinical diagnosis, rule out other pathologies, and establish the most appropriate therapeutic procedure. Further research is needed to understand the potential link between Co-19 and OLP.

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Rhinocerebral mucormycosis: a systematic review of case reports and case series from a global perspective

Cited by 5 publications

References 44 publications

Coinfecciones emergentes: la intersección de mucormicosis, paracoccidioidomicosis y COVID-19

Coinfecciones emergentes: la intersección de mucormicosis, paracoccidioidomicosis y COVID-19

Oral Manifestations of Mucormycosis: A Systematic Review

COVID-19 and Oral Lichen Planus: Between an “Intriguing Plot” and the “Fata Morgana Effect”

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