Rhinobronchial syndrome: Pathogenesis and correlation with allergic rhinitis in children

Cassano, Michele; Maselli, A.; Mora, Francesco; Cassano, Pasquale

doi:10.1016/j.ijporl.2008.03.017

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…This may be the result of a causal nexus between primary nasal stimulation and secondary bronchopulmonary disease called the rhinobronchial syndrome [35,36]. Another explanation of co-existence may that asthma and allergic rhinitis share numerous common pathophysiological features and primary immune response to an allergic stimulus is initially local and is followed by a more generalized airway reaction.…”

Section: Discussionmentioning

confidence: 99%

“…Although limited for children, there are studies supporting both explanations. Cassano et al [35] reported that co-existence of nasal and bronchial diseases seems to be due to the action of aeroallergens which, by releasing mediators, act on the upper and lower airways but in those cases in which severe persistent nasal obstruction predominates, a causal correlation between allergic rhinitis and lower airway hyperresponsiveness can be established.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Subjective and objective assessments of seasonal effect in children with seasonal allergic rhinitis

Giniş

Bostancı

Özmen

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subjective and objective assessments of seasonal effect in children with seasonal allergic rhinitis

Giniş

Bostancı

Özmen

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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“…Allergic rhinitis (AR), a well-described disease entity with extra-nasal manifestations, is considered as a major and increasing chronic inflammatory disease in the respiratory tract [39][40][41]. The pathogenesis of AR is associated with inflammatory mediators (e.g., IgE) and sensitized mast cells in the submucosa of the upper aerodigestive tract, which is also involved in various upper airway diseases including otitis media, chronic laryngitis, oral allergy syndrome, and obstructive sleep apnea [40,[42][43][44].…”

Section: Mscs For Allergic Rhinitis Managementmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cells in Allergic Disease Management

Zhang¹,

Han²,

Gao³

2023

Allergic Disease - New Developments in Diagnosis and Therapy

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Allergic diseases are a clump of disorders caused by protective or harmful immune responses to specific exogenous stimulations. To date, the worldwide prevalence of allergic diseases has caused considerable perplex to patients and guardians physically and mentally. Despite the significant advances in preclinical investigation and clinical practice, yet the effective treatment strategies for allergic diseases are far from satisfaction. State-of-the-art renewal has highlighted the involvement of mesenchymal stem/stromal cell (MSC)-based cytotherapy for various allergic disease management including atopic dermatitis, pediatric asthma, allergic rhinitis, and urticaria, which largely attributes to the unique immunomodulatory properties and mode of action via autocrine and paracrine, direct- or trans-differentiation. In this chapter, we mainly focus on the latest updates of MSC-based investigations upon allergic disease administration as well as the concomitant prospective and challenges, which will provide overwhelming new references for MSC-based cytotherapy in regenerative medicine.

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“…Several terms, definition and acronyms such as UAD (1)(2)(3)(4)(5)(6), unified airways disease, (7,8), one airway one disease (9,10), rhino-bronchial syndrome (11), combined airways diseases (12) have been proposed for its identification.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

et al. 2021

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The large amount of evidence and the renewed interest on upper and lower airways involvement in infectious and inflammatory diseases has led Interasma (Global Asthma Association) to take a position on United Airways Diseases (UAD). Starting from an extensive literature review, Interasma excecutive committee discussed and approved this Manifesto developed by Interasma scientific network (INES) members. The manifesto describes the evidence gathered to date and defines, states, advocates, and proposes issues on UAD (rhinitis, rhinosinusitis and nasal polyposis), and concomitant/comorbid lower airways disorders (asthma, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis, obstructive sleep apnoea) with the aim of challenging assumptions, fostering commitment, and bringing about change.UAD refer to clinical pictures characterized by the coexistence of upper and lower airways involvement, driven by a common pathophysiological mechanism, leading to a greater burden on patient's health status and requiring an integrated diagnostic and therapeutic plan.The high prevalence of UAD must be taken into account. Upper and lower airways diseases influence disease control and patient's quality of life. Patients with UAD need to have a timely and adequate diagnosis, treatment, and, when recommended, referral for management in a specialized center. Diagnostic testing including skin prick or serum specific IgE, lung function, fractional exhaled nitric oxide (FeNO), polysomnography, allergen-specific immunotherapies, biological therapies and homebased continuous positive airway pressure (CPAP) whenever these are recommended, should be part of the management plan for UAD.Education of medical students, physicians, health professionals, patients and caregivers on the UAD is needed.

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Rhinobronchial syndrome: Pathogenesis and correlation with allergic rhinitis in children

Cited by 7 publications

References 23 publications

Subjective and objective assessments of seasonal effect in children with seasonal allergic rhinitis

Subjective and objective assessments of seasonal effect in children with seasonal allergic rhinitis

Mesenchymal Stem/Stromal Cells in Allergic Disease Management

Manifesto on united airways diseases (UAD): an Interasma (global asthma association – GAA) document

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