Rhino-orbital Mucormycosis - A Dreaded Clinical Entity

Swain, Santosh Kumar; Lenka, Smarita; Das, Sudipta Sekhar

doi:10.31782/ijcrr.2020.122434

Cited by 14 publications

(10 citation statements)

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“…Although immune deficiency is an important risk factors for co-fungal infections, there are several other diseases also provide chance for mucormycosis in children. Hematological malignancy is an important risk factor for mucormycosis [13]. In one study, the incidence of mucormycosis among children with acute lymphoblastic leukemia (ALL) was 2.2% [14].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 associated mucormycosis in head and neck region of children during current pandemic: Our experiences

Swain¹,

Jena²,

Lenka³

2021

polp

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Aim: Mucormycosis is a rare but severe fungal infection, particularly found in immunocompromised patients. Currently this dreaded mucormycosis is rising among COVID-19 paediatric patients during their treatment period or after their discharge from hospital. It is also called as black fungus. The aim of this study is to evaluate the COVID-19 associated mucormycosis (CAM) in head and neck region of the paediatric patients with its clinical manifestations and management. Material and methods: This is a descriptive and prospective study of paediatric patients with COVID-19 associated mucormycosis (CAM) carried out at a postgraduate teaching hospital. This study was conducted between March 2020 to April 2021. Patient profile such as age, sex, comorbidities, clinical presentations, diagnosis and treatment of the CAM were analysed. There were 12 paediatric patients of CAM were enrolled in this study. Results: Out of 12 paediatric patients of CAM, there were eight male and four female patients, aged from 3 years to 16 years. Out of the 12 patients, 3 were diabetic (25%). Three patients (25%) were taking prolonged systemic steroids with prolonged hospital ICU stay. Two children (16.66%) were under chemotherapy for acute leukaemia. The common clinical symptoms were facial swelling, facial pain, nasal block and nasal discharge. Diagnosis was confirmed by histological examination. All were treated with endoscopic surgical debridement and amphotericin B. Two patients were passed away; one was due to cerebral involvement and another was due to respiratory failure by pneumonia. Conclusions: Early identification and prompt treatment in paediatric patients with CAM are required. Aggressive endoscopic surgical debridement for local control and appropriate systemic antifungal treatment will help to improve the prognosis and survival of the patients.

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Section: Discussionmentioning

confidence: 99%

COVID-19 associated mucormycosis in head and neck region of children during current pandemic: Our experiences

Swain¹,

Jena²,

Lenka³

2021

polp

Self Cite

View full text Add to dashboard Cite

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“…This deepens into the dermis and forms hyperkeratotic plaques via exudative and necrotic ulcers along with granulomatous inflammation. [80][81][82] • The above scenario leads to cell deficiency and favors conditions like acidosis and hyperglycemia. The Proliferated fungal hyphae in turn destroy endothelial cells angio invasion, successive thrombosis, tissue necrosis, and dissemination of infection throughout the body.…”

Section: Pathophysiologymentioning

confidence: 99%

A Comparative Overview of Various Fungal Menaces Amidst Corona Virus Disease

C¹

2023

Journal of Pharmaceutical Negative Results

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The disastrous Coronavirus Disease outbreak declared as a global pandemic, has become a potential hazard to public health. The second wave of COVID-19 in India has been strongly linked to the rising cases of various fungal infections including mucormycosis, aspergillosis, candidiasis, and mucor septicus. These fungal infections have been a cause for alarm for the general public. The color-coding of the fungal infections is primarily based on the symptoms observed in the infected patients and not based on the color of the fungi itself. For busting the myths behind fungal infections, a comprehensive and deeper understanding of the facts is needed to overcome this challenge. Rapid diagnosis, reversal of underlying predispositions, surgical excision or debridement, and optimal antifungal therapy are some of the crucial factors in combating these fungal infections. This article provides a comparative review of literature on various fungal infections during COVID-19, that have been threatening worldwide, predominantly in India. A well-established databases literature search was conducted.

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“…The infection spreads to other sites causing inflammation, thrombosis and angioinvasion cause blurred vision and ocular alterations [9,10]. It is understood that during this process, fungal cells require iron, which is sequestered with iron binding proteins in healthy people, whereas acidosis results in dissociation of iron from sequestering protein and release of free iron (Fe 3+ ) [19]. All these factors, as shown in Fig.…”

Section: Molecular Mechanism Of Mucormycosis In Covid-19 Patientsmentioning

confidence: 99%

Resolving the equation between mucormycosis and COVID-19 disease

Pasrija

Naime

2022

Mol Biol Rep

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The COVID-19 patients, both infected and recovered are rapidly contracting mucormycetes infections due to the ‘Mucorales’ order, under Zygomycetes class of fungi. The mucorales fungi commonly known to exist in our natural surroundings including soil, but the frequency of incidences was never rampant. This sudden spike in infections, is locally known as ‘black fungus,’ and is affecting various organs, including- eyes, sinuses, nose, brain, skin, intestine, lungs, etc. The severity of situation is ascertainable from the fact that, in certain cases surgical eye/jaws removal persists as the only viable option to avert mortality, as therapeutic interventions are limited. This epidemic situation intrigued experts to investigate the probable reason behind this unpredicted escalation in reported cases, including in recuperated COVID-19 patients, as person-to-person spread of infection is not common. The comparison of physiological parameters in healthy and COVID-19 afflicted patients highlights that the underlying conditions including diabetes mellitus, steroidal therapy, lymphopenia (decreased CD4+ and CD8+ lymphocytes), deregulated cytokine release storm, elevated free iron levels (hemosiderosis) in blood and insulin insensitivity are playing major roles in deteriorating conditions in rarely pathogenic fungal infections. This review is an attempt to explain the rationalities that makes people vulnerable to mucormycetes infection.

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Rhino-orbital Mucormycosis - A Dreaded Clinical Entity

Cited by 14 publications

References 0 publications

COVID-19 associated mucormycosis in head and neck region of children during current pandemic: Our experiences

COVID-19 associated mucormycosis in head and neck region of children during current pandemic: Our experiences

A Comparative Overview of Various Fungal Menaces Amidst Corona Virus Disease

Resolving the equation between mucormycosis and COVID-19 disease

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