Rhinitis is associated with a greater risk of intermittent claudication in adults

Ferrari, Marcello; Pesce, Giancarlo; Marcon, Alessandro; Vallerio, Paola; Pasini, Anna Maria Fratta; Marco, Roberto de

doi:10.1111/all.12354

Cited by 7 publications

(7 citation statements)

References 38 publications

(39 reference statements)

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“…13 In a recent retrospective cohort study, Chung et al 14 found in Taiwan that patients with asthma were at a 1.66-fold greater hazard to develop an acute coronary syndrome than those without the asthma history ( P < 0.001). Ferrari et al 15 found patients with asthma are at higher risk of intermittent claudication, but not reach statistical significance. In the present study, we provide a relative “real world” scenario wherein the diagnosis of asthma and PAD are due to actual medical consultations.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Yao

Shen

et al. 2016

Medicine

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Asthma has been associated with the atherosclerosis risk, but not clear of peripheral artery disease (PAD). We attempted to examine the risk of PAD in patients with asthma.From the insurance claims data of Taiwan, we identified 28,158 newly diagnosed asthma patients in 2000 to 2005 and 56,316 persons without asthma randomly selected into the comparison cohort, frequency matched by sex, age, and the date of diagnosis. Both cohorts were followed up until the end of 2011 to estimate the incident PAD. Adjusted hazard ratios (aHRs) of PAD were estimated using the Cox proportional hazards model after controlling for sex, age, and comorbidities.The incidence of PAD was 1.46 times higher in the asthma cohort than in the comparison cohort, with an aHR of 1.34 [95% confidence interval (CI) = 1.24–1.45]. Incidence of PAD was higher in men, the aged, and those with comorbidities in both cohorts. The aHRs of PAD remained significant for the asthma cohort in all subgroups of sex, age, and the presence of comorbidity. The aHRs of PAD were 14.1 (95% CI = 8.18–24.5) in asthma patients with multiple emergency visits and 22.3 (95% CI = 15.6–31.9) for those with multiple hospitalizations.Although smoking is a potential confounding factor, this study suggests patients with asthma have a significantly higher risk of developing PAD than the general population. The results also support the notion that poor control of asthma status is a key factor in subsequent PAD development.

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Section: Discussionmentioning

confidence: 95%

“…14 A recent multicase-control study showed asthmatic patients with rhinitis were at higher risk of intermittent claudication, but not significant. 15 However, the association between asthma and PAD has been less investigated.…”

Section: Introductionmentioning

confidence: 99%

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Yao

Shen

et al. 2016

Medicine

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“…. Rhinitis was associated with peripheral arterial disease, a predictor of future cerebrovascular and cardiovascular events, independent of the presence of atopy .…”

Section: Risk Factors For Ar and Allergen Sensitizationmentioning

confidence: 86%

Latest developments in allergic rhinitis in Allergy for clinicians and researchers

Wang

2015

Allergy

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Research efforts in allergic rhinitis have always been intense. Over the past 3 years, numerous breakthroughs in basic science and clinical research have been made, augmenting our understanding of this condition that afflicts a significant proportion of the global population. New epidemiological findings, novel insights into the molecular and cellular mechanisms of allergy, enhancement of current developmental theories, new concepts of the goals and endpoints of management, and latest therapeutic modalities that includes the harnessing of information technology and big data are some areas where important advances were made. We attempt to bring you a summary of the key research advances made in the field of allergic rhinitis from 2013 to 2015.Allergic rhinitis (AR) is a common condition that affects a significant proportion of the global population, across all age groups, and is often a life-long condition. Its impact on direct and indirect healthcare costs is significant and it negatively impacts patients' quality of life, work performance and social functioning (1). Overall, AR poses a significant public health burden. Research efforts on AR have been intensive given its significance. Busy clinicians and scientists may find it difficult to keep up with the plethora of published articles and sift out the salient points. We performed this review of articles published mainly in Allergy (2013Allergy ( -2015, a representative journal in the field, to provide an update on important research findings on AR.Interesting research findings on the epidemiology, developmental theories and pathophysiology, novel technology and management have emerged. However, these studies are of diverse and unique content. We grouped these studies into a coherent bundle, which might aid in contextual understanding and interpretation. Areas of debate and uncertainty are discussed for potential research to be considered for the clarification of these knowledge gaps. Prevalence, burden and comorbidities of AR Preschool children: a neglected populationThe international ISAAC studies have elucidated the prevalence of AR, AD and asthma in children above the age of six and have enhanced our understanding of allergy in paediatric populations (2, 3). Data in preschool children are, however, lacking. A nationwide study in Portugal found that 43.4% of preschool children had rhinitis based on an adapted ISAAC questionnaire (4). A Brazilian study used Phase III EISL and modified ISAAC questionnaires to assess rhinitis symptoms in infants aged 12-15 months. This study found that 48.3% of children had at least one episode of sneezing, runny or blocked nose without cold or flu in the first year of life, and a quarter of infants had recurrent wheezing (≥3 episodes) and wheezing was more frequent in the presence of AR symptoms (5). A higher prevalence in preschool children may be expected as infectious rhinitis or other types of rhinitis is common due to a wide spectrum of risk factors (e.g. viruses, bacteria, moulds and other stimAllergy 70 (2015) ...

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“…Apart from the unlikely possibility that this association is due to chance, there are at least two plausible interpretations [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Ferrari et al [3] instead have shown that patients with rhinitis, regardless of the presence of atopy, have a higher risk of suffering from intermittent claudication [2].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Functionality and Echocardiographic Parameters in Patients with Rhinitis and Nasal Polyps

Bulzis¹,

Carbonara²,

Dentamaro³

et al. 2016

Arch Med

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Background: Chronic inflammation is associated with accelerated atherosclerosis, endothelial dysfunction and with early cardiovascular disease. Rhinitis and nasal polyps are inflammatory diseases and the local inflammation is often associated with systemic events that they see as a primary cause the endothelial dysfunction. Studies have shown a higher incidence of cardiovascular events such as stroke, intermittent claudication and myocardial infarction in patients with polyposis and/or rhinitis, but studies that have focused on myocardial injury are few and showed echocardiography as a subclinical deficiency of the right longitudinal functions in patients with nasal polyposis.

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Rhinitis is associated with a greater risk of intermittent claudication in adults

Abstract: Our findings suggest that rhinitis is associated with PAD, a predictor of future cerebrovascular and cardiovascular events, independently of the presence of atopy.

Cited by 7 publications

References 38 publications

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Latest developments in allergic rhinitis in Allergy for clinicians and researchers

Endothelial Functionality and Echocardiographic Parameters in Patients with Rhinitis and Nasal Polyps

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