Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study

Slager, Rebecca E.; Poole, Jill; LeVan, Tricia D.; Sandler, Dale P.; Alavanja, Michael C.R.; Hoppin, Jane A.

doi:10.1136/oem.2008.041798

Cited by 62 publications

(55 citation statements)

References 24 publications

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“…In a study on 2245 commercial pesticide applicators, the use of the herbicide pendimethalin or the insecticide organophosphate phorate was associated with at least three episodes of current rhinitis in the past year [11]. Although this study confirmed the results of Chatzi et al [12] on grape farmers exposed to multiple pesticides, it has several limitations: no relationship of nasal symptoms to pesticide exposure was recorded and no clear exposure-response relationship was found.…”

Section: Cross-sectional Studiessupporting

confidence: 50%

Occupational rhinitis: consensus on diagnosis and medicolegal implications

Moscato

Rolla

Siracusa

2011

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Section: Cross-sectional Studiessupporting

confidence: 50%

Occupational rhinitis: consensus on diagnosis and medicolegal implications

Moscato

Rolla

Siracusa

2011

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…Pesticide exposure is also recognized as a risk factor for asthma, especially atopic asthma 26) . Besides pesticides, the workers examined in this study handle grain and hay that also trigger respiratory symptoms including those of rhinitis 27) and chronic bronchitis 28) . However, OP and C exposure appeared to be largely responsible for respiratory health impairment, because we found a strong positive association between ChE inhibition and respiratory problems, and subjects with more than 50% reduction in RBC AChE had the highest prevalence of respiratory symptoms.…”

Section: Discussionmentioning

confidence: 99%

Chronic Exposures to Cholinesterase‐inhibiting Pesticides Adversely Affect Respiratory Health of Agricultural Workers in India

Chakraborty

Mukherjee

Roychoudhury

et al. 2009

Journal of Occupational Health

105

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Chronic Exposures to Cholinesteraseinhibiting Pesticides Adversely Affect RespiratoryHealth of Agricultural Workers in India: Sreeparna CHAKRABORTY, et al. Department of Experimental Hematology, Chittaranjan National Cancer Institute, India-Objective: The impact of long term exposure to cholinesterase (ChE)-inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Methods: Three hundred and seventy-six nonsmoking agricultural workers (median age 41 yr) from eastern India who sprayed OP and C pesticides in the field and 348 age-and sex-matched control subjects with non-agricultural occupations from the same locality were enrolled. Prevalence of respiratory symptoms was obtained by questionnaire survey, and pulmonary function tests were carried out by spirometry. Chronic obstructive pulmonary disease (COPD) was diagnosed by the Global Obstructive Lung Disease (GOLD) criteria, and erythrocyte acetylcholinesterase (AChE) was measured by the Ellman method. Results: Agricultural workers had greater prevalences of upper and lower respiratory symptoms, and appreciable reduction in spirometric measurements. Overall, lung function reduction was noted in 48.9% of agricultural workers compared with 22.7% of control, and a restrictive type of deficit was predominant. COPD was diagnosed in 10.9% of agricultural workers compared with 3.4% of controls (p<0.05 in χ 2 test), and the severity of the disease was greater in agricultural workers. Red blood cell (RBC) AChE was lowered by 34.2% in agricultural workers, and the fall in AChE level was positively associated with respiratory symptoms, lung function decrement and COPD after controlling for education and income as potential confounders. Conclusions: Long-term exposure to cholinesteraseinhibiting agricultural pesticides currently in use in India is associated with a reduction in lung function, COPD and a rise in respiratory symptoms. (J Occup Health 2009; 51: 488-497)

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“…In Costa Rica, pesticide exposure was associated with respiratory health problems among indigenous women [31]. Rhinitis arising from pesticide exposure was also noted among commercial pesticide applicators [32].…”

Section: Discussionmentioning

confidence: 99%