Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin–nicotinamide induced adult male diabetic rats

Adam, Siti Hajar; Giribabu, Nelli; Rao, Pasupuleti Visweswara; Sayem, Abu Sadat Md.; Arya, Aditya; Panichayupakaranant, Pharkphoom; Korla, Praveen Kumar; Salleh, Naguib

doi:10.1016/j.ejphar.2015.12.028

Cited by 31 publications

(20 citation statements)

References 41 publications

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“…15 minutes after injection of NA, to create type-2 diabetes, STZ (55 mg/ kg/b.w. in 0.1 M cold citrate buffer, pH 4.5) was injected [20]. After 72 h, the blood glucose levels were monitored with a glucometer (Contour TM TS, Bayer Diagnostics) and the rats with plasma glucose levels >200 mg/dl were selected for further study [21].…”

Section: Experimental Designmentioning

confidence: 99%

Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes

Çam¹,

Yildiz²,

Ertaş³

et al. 2017

mpj

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Some Salvia and Thymus species of Lamiaceae family come into prominence with strong antidiabetic effects. Compared to the other species, there are limited studies on antidiabetic activity of Salvia triloba (ST) and Thymus praecox subsp. skorpilii var. skorpilii (TPS). The aim of this study was to adjust the dosage and to determine the antidiabetic effects of methanol extracts of ST and TPS in streptozotocin/nicotinamide-induced diabetic rats. Type II diabetes mellitus (T2DM) was induced by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) dissolved in 0.1 M cold citrate buffer (pH 4.5) at a dose of 55 mg/kg/body weight (b.w.) and nicotinamide (100 mg/kg/b.w.) was given prior to STZ injection. For adjusting dosage, oral glucose tolerance test (OGTT) was used while insulin tolerance test (ITT), OGTT, blood glucose levels and animal weights were used to evaluate the antidiabetic effects of ST and TPS. According to the OGTT, the most effective doses for ST and TPS were 200 mg/kg and 100 mg/kg, respectively. At the end of three weeks, blood glucose levels of control goup reached to 462.50 mg/dl, whereas ST and TPS-treated groups blood glucose levels decreased less than 200.00 mg/dl. In conclusion, the present study suggests that both of ST and TPS methanolic extracts may be of therapeutic benefit in diabetes and thus need to further studies. Keywords

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Section: Experimental Designmentioning

confidence: 99%

Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes

Çam¹,

Yildiz²,

Ertaş³

et al. 2017

mpj

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“…125,126) The methanol extract (200 mg/kg) was also effective in normalizing the levels of mitochondrial (succinate dehydrogenase, glutamate dehydrogenase and glucose-6-phosphate dehydrogenase) and liver (glucokinase, phosphofructokinase, and pyruvate kinase) enzymes, as well as the glycogen level in diabetic rats. 127,128) Moreover, the same dose of methanol extract significantly normalized the level of liver function markers and protein contents in the liver tissue of diabetic rats. 128) The major phytoconstituents in R. nasutus are 1,4-naphthoquinone esters, namely rhinacanthins (Fig.…”

Section: Antidiabetic Potential Of Naphthoquinone-containing Plants Imentioning

confidence: 99%

“…127,128) Moreover, the same dose of methanol extract significantly normalized the level of liver function markers and protein contents in the liver tissue of diabetic rats. 128) The major phytoconstituents in R. nasutus are 1,4-naphthoquinone esters, namely rhinacanthins (Fig. 1).…”

Section: Antidiabetic Potential Of Naphthoquinone-containing Plants Imentioning

confidence: 99%

“…Recently, rhinacanthin-C (5, 20 mg/kg/d) has been reported for its hypoglycemic, hypolipidemic, and pancreatic protective effects in STZ nicotinamide induced diabetic rats. 129) Rhinacanthin-C lowered the blood glucose level and lipid profile, and also exerting a pancreatic protective effect by reducing the level of inflammatory and apoptosis mediators i.e., tumor necrosis factor alpha (TNFα), Ikkβ, and caspase-3 in diabetic rats. An enhanced insulin level was also observed, due to a higher glucose transporter type 2 (GLUT2) level in the pancreas.…”

Section: Antidiabetic Potential Of Naphthoquinone-containing Plants Imentioning

confidence: 99%

“…130,132) TNFα, Ikkβ, and caspase-3 reduction in the pancreas of diabetic rats interlink anti-inflammatory activity to antidiabetic potential, while antioxidant and GLUT2 enhancement in the pancreas sensitize insulin secretion to control glycemia. 129) Plumbagin exerts an antidiabetic effect via GLUT4 translocation, and normalizing serum and hepatic carbohydrate metabolizing enzymes. 141) Shikonin (47) is a naturally occurring 1,4-naphthoquinone, which contributes to the purple color of Lithospermum erythrorhizon SIEBOLD & ZUCC.…”

Section: Antidiabetic Mechanisms Of Naphthoquinonesmentioning

confidence: 99%

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Antidiabetic Naphthoquinones and Their Plant Resources in Thailand

Shah

Keach²,

Panichayupakaranant

2018

Chem. Pharm. Bull.

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Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity. Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of α-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARγ) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and downstream regulation to control obesity, which is one of the important risk factors for diabetes. Naturally occurring naphthoquinones, as well as their plant sources, are therefore of interest for exploring their antidiabetic potential. The present review aims to overview the antidiabetic potential of naphthoquinones and their plant resources in Thailand.

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