Rheumatologic and Skeletal Changes in Acromegaly

Lieberman, Steven A.; Björkengren, Ann; Hoffman, Andrew R.

doi:10.1016/s0889-8529(18)30205-6

Cited by 67 publications

(25 citation statements)

References 87 publications

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“…These changes also settle with dose reduction and are possibly due to swelling of articular cartilage, although the precise mechanism remains unknown. Myopathy and arthralgia commonly occur in acromegaly, and it is likely that these symptoms arise from GH excess (151)(152)(153)(154).…”

Section: Reported Adverse Effects Of Gh Replacementmentioning

confidence: 99%

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Carroll¹,

Christ²,

Bengtsson³

et al. 1998

The Journal of Clinical Endocrinology & Metabolism

706

455

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Section: Reported Adverse Effects Of Gh Replacementmentioning

confidence: 99%

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Carroll¹,

Christ²,

Bengtsson³

et al. 1998

The Journal of Clinical Endocrinology & Metabolism

706

455

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“…Control of IGF1 and GH by somatostatin agonists has been shown to reduce joint thickness in acromegaly by ultrasonography (10,11). High levels and long duration of excess growth mediators alone have not been shown to correlate with greater joint damage (1,3,12). Other factors will contribute to development and severity of acromegalic arthropathy, as in osteoarthritis, including age, gender, genetic factors, local biomechanics, injury, obesity, deformity and muscle weakness (13).…”

Section: Introductionmentioning

confidence: 99%

Impact of musculoskeletal disease on quality of life in long-standing acromegaly

Miller¹,

Doll²,

David³

et al. 2008

European Journal of Endocrinology

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Objective: To provide rheumatological assessment of patients with long-standing acromegaly and investigate the impact of musculoskeletal disease on quality of life. Design: Cross-sectional observational study. Methods: Fifty-eight patients diagnosed with acromegaly at least 5 years previously were interviewed and examined by a rheumatologist. Each patient completed the short form-36 (SF-36), arthritis impact measurement scales 2 (AIMS2) and acromegaly quality of life questionnaires (AcroQol). Results: Fifty-two out of 58 (90%) reported musculoskeletal pain, with 29 (50%) reporting neck pain. Hip osteoarthritis was present in 49 (84%) and knee osteoarthritis in 20 (34%). Half the patients (52%) reported sleep disturbance, but only 2 (3.5%) had fibromyalgia. Ten (17.2%) had previously undergone carpal tunnel decompression. Fifty-one (88%) patients had consulted their general practioner and 31 (54%) complementary therapists. SF-36, AIMS2 and AcroQol scores were lower in patients with musculoskeletal pain. Conclusions: This study of musculoskeletal problems in patients with acromegaly reports systematic rheumatological examination, use of medical services and quality of life scores. Musculoskeletal problems should be routinely addressed in acromegaly by both endocrinologist and rheumatologist and a multidisciplinary approach taken to management.European Journal of Endocrinology 158 587-593

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“…4) [1, 38,39]. GH and IGF-I excesses are responsible for replication of articular chondrocytes and increased matrix synthesis [1].…”

Section: Acromegalic Arthropathymentioning

confidence: 99%

“…Therefore, joint thickness may also be increased in patients cured by surgery compared to controls [38]. At this stage there are in fact calcifications and osteophyte formation, cartilagineous fissures extend to the subchondral bone, articular cartilage becomes ulcerated while bones show accelerated turnover, eburnation and subchondral cyst formation [1].…”

Section: Acromegalic Arthropathymentioning

confidence: 99%

Bone and joint alterations in acromegaly

Morselli

Manetti

Cosci

et al. 2006

J Orthopaed Traumatol

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Growth hormone (GH) is fundamental for the maintenance of bone mass and metabolism both during childhood and in adulthood. This effect is due to a complex interaction between circulating GH and IGF-I produced peripherally. In vitro data and experimental animal models have clarified many of the regulatory mechanisms underlying the characteristic skeletal changes occurring in acromegaly. This review focuses on the effects of GH excess on bone metabolism and mass in acromegalic patients and, in particular, on the influence of factors such as hypogonadism, gender, age and therapy on bone metabolism and arthropathy.

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Rheumatologic and Skeletal Changes in Acromegaly

Cited by 67 publications

References 87 publications

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Impact of musculoskeletal disease on quality of life in long-standing acromegaly

Bone and joint alterations in acromegaly

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