Rheumatologic and extraintestinal manifestations of inflammatory bowel diseases

Colìa, Ripalta; Corrado, Addolorata; Cantatore, Francesco Paolo

doi:10.1080/07853890.2016.1195011

Cited by 41 publications

(39 citation statements)

References 58 publications

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“…“The basic etiological factor in the case of all granulomas is probably the presence of a nidus of insoluble material which, if small enough is ingested by phagocytic cells, or, if too large, remains extracellular.” The central macrophages in these granulomata are surrounded by lymphocytes. The condition can also be associated with extra intestinal manifestations most commonly affecting the joints, skin, eyes and mouth …”

Section: General Introductionmentioning

confidence: 99%

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The role of neutrophils in the pathogenesis of Crohn's disease

Segal

2018

Eur J Clin Investigation

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Crohn's disease (CD) is caused by a trigger, almost certainly enteric infection by one of a multitude of organisms that allows faeces access to the tissues, at which stage the response of individuals predisposed to CD is abnormal. In CD the failure of acute inflammation results in the failure to recruit neutrophils to the inflammatory site, as a consequence of which the clearance of bacteria from the tissues is defective. The retained faecal products result in the characteristic chronic granulomatous inflammation and adaptive immune response. Impaired of digestion of bacteria and fungi by CGD neutrophils can result in a similar pathological and clinical picture. The neutrophils in CD are normal and their inadequate accumulation at sites of inflammation generally results from diminished secretion of proinflammatory cytokines by macrophages consequent upon disordered vesicle trafficking.

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Section: General Introductionmentioning

confidence: 99%

“…The condition can also be associated with extra intestinal manifestations most commonly affecting the joints, skin, eyes and mouth. 4…”

Section: General Introductionmentioning

confidence: 99%

The role of neutrophils in the pathogenesis of Crohn's disease

Segal

2018

Eur J Clin Investigation

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“…IBD is associated with dynamic interactions among genetic, environmental, gut microbiome, and immunologic factors. [6][7][8] The relationship between IBD and IPF remains unclear, but some case reports have suggested an association between IPF and IBD. 5 A wide spectrum of bronchopulmonary manifestations has been reported in IBD, including chronic bronchitis, pulmonary vasculitis, eosinophilic pneumonia, and IPF.…”

Section: Introductionmentioning

confidence: 99%

“…5 A wide spectrum of bronchopulmonary manifestations has been reported in IBD, including chronic bronchitis, pulmonary vasculitis, eosinophilic pneumonia, and IPF. [6][7][8] The relationship between IBD and IPF remains unclear, but some case reports have suggested an association between IPF and IBD. [9][10][11][12] To date, population-based, epidemiologic evidence regarding the risk of comorbid IPF in patients with IBD has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of idiopathic pulmonary fibrosis in inflammatory bowel disease: A nationwide study

Kim

Chun

Lee

et al. 2019

J of Gastro and Hepatol

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Background and Aim The relationship between inflammatory bowel disease (IBD) and idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the risk for developing IPF in patients with IBD using a nationwide population‐based study. Methods Using claims data from the National Health Insurance service in Korea, patients with IBD, including Crohn's disease (CD) and ulcerative colitis (UC), were identified through both the 10th revision of the International Statistical Classification of Diseases and Related Health Problems and rare and intractable disease program codes from January 2010 to December 2013. We compared 38 921 IBD patients with age‐matched and sex‐matched individuals without IBD in a ratio of 1:3. Patients with newly diagnosed IPF were identified by both the 10th revision of the International Statistical Classification of Diseases and Related Health Problems and rare and intractable disease registration codes. Results During a mean 4.9‐year follow‐up, the incidence of IPF in patients with IBD was 33.21 per 100 000 person‐years. The overall risk of IPF was significantly higher in IBD patients than in non‐IBD controls (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.20–2.20; P = 0.003). In patients with CD, the incidence (per 100 000 person‐years) of IPF was 26.04; in controls, the incidence was 9.15 (HR, 2.89; 95% CI, 1.46–5.72; P = 0.002). The incidence of IPF in patients with UC tended to be higher than in controls (36.66 vs 26.54 per 100 000 person‐years; 95% CI, 0.99–1.99; HR, 1.41; P = 0.066). The risk of developing IPF in patients with IBD was higher in male patients than in female patients (P = 0.093 in CD; P = 0.147 in UC by interaction analysis). Conclusions Patients with IBD, especially CD, have an increased risk of developing IPF.

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“…İnflamatuvar barsak hastalıkları (İBH) kronik inflamasyonla karakterli hastalıklardır. Bu hastalıklar primer olarak barsakları etkilese de bir çok barsak dışı organ ve sistemi de etkilemektedir (1). Trombozlar İBH'nın iyi bilinen vasküler manifestasyounudur.…”

Section: Introductionunclassified

İnflamatuvar barsak hastalıklarında tromboz sıklığı ve trombozun hastalık seyrine olan etkisi

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Kılıç

et al. 2017

Endoskopi Gastrointestinal

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Backgrounds and Aims: Inflammatory bowel disease increases the risk of thrombosis. Here we have present our patients with ulcerative colitis and Crohn's disease having thrombosis, their clinical course, and the properties of thrombosis in these patients. Materials and Methods: A total of 3.128 patients who were followed up in the Türkiye Yüksek İhtisas Training and Research Hospital Inflammatory Bowel Disease Department were investigated for thrombosis. Results: Of the total, 20 patients with thrombosis were included in the study. The median age of the patients was 40,45 (22-70 years). Of these, 16 patients were men and 6 were women. Thrombosis was diagnosed in deep veins in 10 patients. In addition, 4 patients were diagnosed with pulmonary emboly with deep vein thrombosis, 3 thrombophlebitis, 1 with cerebral vein thrombosis, 1 with mesenteric vein thrombosis, and 2 with portal and hepatic vein thrombosis. The median time between the first inflammatory bowel disease diagnosis and the thrombosis diagnosis was 16 months (2-240). Thrombosis was diagnosed in 15 patients while they were in the active phase of their disease. The treatment of 13 patients was upgraded during their clinical course. Conclusion: Inflammatory bowel disease is a thrombophilic condition. An early diagnosis and appropriate treatment of these patients are essential in order to reduce morbidity and mortality. Thrombosis may predict severe disease. An active disease must be considered as a pre-thrombotic situation, and prophylactic anticoagulation must be integrated within the treatment.

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Rheumatologic and extraintestinal manifestations of inflammatory bowel diseases

Cited by 41 publications

References 58 publications

The role of neutrophils in the pathogenesis of Crohn's disease

The role of neutrophils in the pathogenesis of Crohn's disease

Increased risk of idiopathic pulmonary fibrosis in inflammatory bowel disease: A nationwide study

İnflamatuvar barsak hastalıklarında tromboz sıklığı ve trombozun hastalık seyrine olan etkisi

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