Rheumatoid stricture of oesophagus.

John, Vera; Stirling, A J; Mathews, H R

doi:10.1136/bmj.1.6111.479

Cited by 8 publications

(2 citation statements)

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“…Severe sicca manifestations from associated Sjögren's syndrome may lead to problems with deglutition and overall patient comfort. Esophageal dysmotility may be due to amyloidosis or to GI vasculitis, the latter sometimes causing esophageal strictures from local ischemia [39].…”

Section: Gi Manifestations Of Ramentioning

confidence: 99%

Gastrointestinal and Hepatic Manifestations of Rheumatoid Arthritis

Ebert

Hagspiel

2011

Dig Dis Sci

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Rheumatoid arthritis (RA), characterized by inflammation of the synovium and surrounding structures, has a prevalence of 0.5-1%. Rheumatoid vasculitis (RV) is an inflammatory condition of the small- and medium-sized vessels that affects up to 5% of patients with RA with intestinal involvement in 10-38% of these cases. Clinically apparent RV of the gastrointestinal (GI) tract, while rare, is often catastrophic, resulting in ischemic ulcers and bowel infarction. Vasculitis of the colon may present as pancolitis clinically similar to ulcerative colitis. Rectal biopsies that include submucosal vessels are positive for vasculitis in up to 40% of cases. Abnormal esophageal motility in RA may result in heartburn and dysphagia. Chronic atrophic gastritis may be associated with hypergastrinemia and hypo- or achlorhydria, promoting small bowel bacterial overgrowth. RA is the most common cause of secondary amyloidosis with GI symptoms in 22% of affected patients. Although amyloid is usually found in the liver, it is rarely evident clinically. Felty's syndrome occurs in less than 1% of patients with RA and is characterized by neutropenia and splenomegaly. The liver may be involved with portal fibrosis or nodular regenerative hyperplasia. Liver histology is abnormal in 92% of RA patients at autopsy, although the changes are usually mild without associated hepatomegaly. Drug-induced liver disease may occur with aspirin, sulfasalazine, and methotrexate. Significant liver damage is rare if the drug is discontinued or the patient is properly monitored. RA can affect both the GI tract and the liver; changes are usually mild except with RV.

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Section: Gi Manifestations Of Ramentioning

confidence: 99%

Gastrointestinal and Hepatic Manifestations of Rheumatoid Arthritis

Ebert

Hagspiel

2011

Dig Dis Sci

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“…Abnor malities of the esophagus were reported by a number of authors, and these were charac terised by dilatation [64] or, more rarely, by stenosis [65,66]. EMD may also be present during this illness [66].…”

Section: Rheumatoid Polyarthritismentioning

confidence: 99%