Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis

Bennett, Joshua; Pratt, Arthur G.; Dodds, Richard; Sayer, Avan A.; Isaacs, John D.

doi:10.1038/s41584-023-00921-9

Cited by 42 publications

(34 citation statements)

References 149 publications

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“…While the exact etiology of RA remains elusive, immune responses, genetic predispositions, and environmental influences were all postulated to contribute to its intricate pathogenesis 10 . Notably, individuals with RA often exhibit an array of aging‐related symptoms, such as fatigue, 11 diminished muscle mass and strength, 12 and cognitive decline 13 . Such observations suggest a potential association between the aging process and the emergence and progression of RA.…”

Section: Introductionmentioning

confidence: 99%

Accelerated biological aging as a potential risk factor for rheumatoid arthritis

Dan,

Yang,

Zhu

et al. 2024

Int J of Rheum Dis

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ObjectsPrevious studies have suggested a potential correlation between rheumatoid arthritis (RA) and biological aging, but the intricate connections and mechanisms remain elusive.MethodsIn our study, we focused on two specific measures of biological age (PhenoAge and BioAge), which are derived from clinical biomarkers. The residuals of these measures, when compared to chronological age, are defined as biological age accelerations (BAAs). Utilizing the extensive UK Biobank dataset along with various genetic datasets, we conducted a thorough assessment of the relationship between BAAs and RA at both the individual and aggregate levels.ResultsOur observational studies revealed positive correlations between the two BAAs and the risk of developing both RA and seropositive RA. Furthermore, the genetic risk score (GRS) for PhenoAgeAccel was associated with an increased risk of RA and seropositive RA. Linkage disequilibrium score regression (LDSC) analysis further supported these findings, revealing a positive genetic correlation between PhenoAgeAccel and RA. PLACO analysis identified 38 lead pleiotropic single nucleotide polymorphisms linked to 301 genes, providing valuable insights into the potential mechanisms connecting PhenoAgeAccel and RA.ConclusionIn summary, our study has successfully revealed a positive correlation between accelerated biological aging, as measured by BAAs, and the susceptibility to RA.

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Section: Introductionmentioning

confidence: 99%

Accelerated biological aging as a potential risk factor for rheumatoid arthritis

Dan,

Yang,

Zhu

et al. 2024

Int J of Rheum Dis

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“…Moreover, there is evidence of a correlation between sarcopenia and autoimmune diseases. For instance, rheumatoid arthritis (RA) patients are at an increased risk for sarcopenia (Bennett, Pratt, Dodds, Sayer, & Isaacs, 2023).Other autoimmune diseases, such as multiple sclerosis, celiac disease, type 1 diabetes, psoriasis, and ulcerative colitis have also been linked to sarcopenia (Jones et al, 2020). Therefore, further investigation into the interplay between sarcopenia, immunity, and inflammation is warranted.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the skeletal muscle immune microenvironment for sarcopenia using transcriptome analysis and histological validation

Shen,

Zong,

Zhao

et al. 2024

Preprint

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Sarcopenia is a condition characterized by the age-related loss of skeletal muscle mass and function. The pathogenesis of the disease is influenced by chronic low-grade inflammation. However, the specific changes in the immune landscape changes of sarcopenic muscle are not yet fully understood. To gain insights into the immune cell composition and interactions, we combined single-nuclei RNA sequencing data, bulk RNA sequencing datasets, and comprehensive bioinformatic analyses on skeletal muscle samples from young, aged, and sarcopenic individuals. Histological staining was then performed on skeletal muscles to validate the distribution of immune cells in clinical samples. Overall, we analyzed the transcriptomes of 101,862 single nuclei, revealing a total of 10 major cell types and 6 subclusters of immune cell types within the human skeletal muscle tissues. Among the immune cells, macrophages constituted the largest immune fraction. A specific marker gene LYVE1 for skeletal muscle macrophages was further identified. Cellular subclasses included four distinct groups of resident macrophages, which play a different role in physiological or non-physiological conditions. Using bulk RNA sequencing data, we identified strong enrichment for a macrophage-rich inflammation in sarcopenia. Our findings demonstrate age-related changes in the composition and cross-talk of immune cells, which contribute to chronic inflammation. Furthermore, macrophages emerge as a potential therapeutic target, thus advancing our understanding of the pathogenesis of sarcopenia.

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“… 12 Similarly, when providing exercise guidance to patients with rheumatoid arthritis (RA), the presence of glucocorticoid-induced osteoporosis should be taken into account to avoid fractures caused by inappropriate exercise. 13 …”

Section: Introductionmentioning

confidence: 99%

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Hu,

Wang,

et al. 2024

CIA

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This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese exercise, intestinal microecology, and rehabilitation therapies for individuals with limited limb movement. By analyzing multiple studies, the article aims to summarize the available evidence to manage sarcopenia in individuals with chronic diseases. The results strongly emphasize the role of resistance training in addressing chronic diseases and secondary sarcopenia. Maintaining the appropriate frequency and intensity of resistance training can help prevent muscle atrophy and effectively reduce inflammation. Although aerobic exercise has limited ability to improve skeletal muscle mass, it does have some positive effects on physical function. Building upon this, the article explores the potential benefits of combined training approaches, highlighting their helpfulness for overall quality of life. Additionally, the article also highlights the importance of dietary supplements in combating muscle atrophy in chronic diseases. It focuses on the importance of protein intake, supplements rich in essential amino acids and omega-3, as well as sufficient vitamin D to prevent muscle atrophy. Combining exercise with dietary supplements appears to be an effective strategy for preventing sarcopenia, although the optimal dosage and type of supplement remain unclear. Furthermore, the article explores the potential benefits of intestinal microecology in sarcopenia. Probiotics, prebiotics, and bacterial products are suggested as new treatment options for sarcopenia. Additionally, emerging therapies such as whole body vibration training, blood flow restriction, and electrical stimulation show promise in treating sarcopenia with limited limb movement. Overall, this article provides valuable insights into non-pharmacological strategies for managing sarcopenia in individuals with chronic diseases. It emphasizes the importance of a holistic and integrated approach that incorporates exercise, nutrition, and multidisciplinary interventions, which have the potential to promote health in the elderly population. Future research should prioritize high-quality randomized controlled trials and utilize wearable devices, smartphone applications, and other advanced surveillance methods to investigate the most effective intervention strategies for sarcopenia associated with different chronic diseases.

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Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis

Cited by 42 publications

References 149 publications

Accelerated biological aging as a potential risk factor for rheumatoid arthritis

Accelerated biological aging as a potential risk factor for rheumatoid arthritis

Characterizing the skeletal muscle immune microenvironment for sarcopenia using transcriptome analysis and histological validation

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

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