Rheumatoid pneumoconiosis: A study in colliery populations in the East Midlands coalfield

Lindars, D. C.; Davies, Dewi

doi:10.1136/thx.22.6.525

Cited by 23 publications

(9 citation statements)

References 11 publications

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“…Calcification of rheumatoid pulmonary nodules is not a frequent finding but may be seen in some patients (29). Such calcification has been observed in patients with Caplan syndrome (rheumatoid pneumoconiosis syndrome, in which rheumatoid pulmonary nodules arise in association with pneumoconiosis, usually in coal workers) (Fig 8) (30,31).…”

Section: Rheumatoid Arthritismentioning

confidence: 94%

Thoracic Manifestations of Collagen Vascular Diseases

Capobianco¹,

Grimberg²,

Thompson³

et al. 2012

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Collagen vascular diseases are a diverse group of immunologically mediated systemic disorders that often lead to thoracic changes. The collagen vascular diseases that most commonly involve the lung are rheumatoid arthritis, progressive systemic sclerosis, systemic lupus erythematosus, polymyositis and dermatomyositis, mixed connective tissue disease, and Sjögren syndrome. Interstitial lung disease and pulmonary arterial hypertension are the main causes of mortality and morbidity among patients with collagen vascular diseases. Given the broad spectrum of possible thoracic manifestations and the varying frequency with which different interstitial lung diseases occur, the interpretation of thoracic images obtained in patients with collagen vascular diseases can be challenging. The task may be more difficult in the presence of treatment-related complications such as drug toxicity and infections, which are common in this group of patients. Although chest radiography is most often used for screening and monitoring of thoracic alterations, high-resolution computed tomography can provide additional information about lung involvement in collagen vascular diseases and may be especially helpful for differentiating specific disease patterns in the lung. General knowledge about the manifestations of thoracic involvement in collagen vascular diseases allows radiologists to provide better guidance for treatment and follow-up of these patients.

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Section: Rheumatoid Arthritismentioning

confidence: 94%

Thoracic Manifestations of Collagen Vascular Diseases

Capobianco¹,

Grimberg²,

Thompson³

et al. 2012

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“…It has also been suggested that this mechanism may occur in coal workers' pneumoconiosis, and this hypothesis is supported by the association shown to exist between rheumatoid arthritis, an accepted auto-immune disease, and the development of a distinctive nodular type of massive fibrosis (Caplan, 1953;Caplan, Payne, and Withey, 1962). Lindars and Davies (1967) suggested that both the quantity of dust in the lungs (which increases with the category of simple pneumoconiosis present (Rivers, Wise, King and Nagelschmidt, 1960) and the immune response of the individual may be involved in the aetiology of PMF. Complicated pneumoconiosis has also been shown to be associated with an abnormal pattern of iron metabolism, with a low serum iron and total iron binding capacity (TIBC) in seropositive (Rose Waaler titre over 1:32) cases and a low TIBC in seronegative cases (Chan, 1969).…”

Section: Resultsmentioning

confidence: 92%

Influence of surgery for peptic ulcer on pneumoconiosis and tuberculosis

Phillips¹

1970

Occupational and Environmental Medicine

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. Influence of surgery for peptic ulcer on pneumoconiosis and tuberculosis. Simple pneumoconiosis in coal miners who have had a partial gastrectomy has often been observed at this Panel to lead to progressive massive fibrosis (PMF). A series comprising 224 men, who had had either a partial gastrectomy, a gastro-enterostomy with or without vagotomy, or a simple closure of a perforated peptic ulcer, was collected over a period of four years. A control series of 220 men who had originally presented with simple pneumoconiosis at least 10 years previously was also studied.Active pulmonary tuberculosis developed in 13 of 106 men (12-2%) following partial gastrectomy compared with 2 of 68 men (2 9%) in the gastro-enterostomy group, 1 of 50 men (2 %) in the perforated peptic ulcer group, and 4 of 220 men (1 8 %) in the control series. Of those who had had a partial gastrectomy, 48-6% progressed to massive fibrosis subsequently, compared with 16-5% in the gastro-enterostomy group, 22% in the perforated peptic ulcer group, and 37 9 % in the control series. Possible reasons for these differences are discussed as well as the current theories of the aetiology of PMF.In view of the increased incidence of tuberculosis and possibly of massive fibrosis in those men who have had a partial gastrectomy in this series, it is recommended that this operation should be avoided in the treatment of peptic ulcer in coal miners with pneumoconiosis. A series comprising 224 men, who had had surgery for peptic ulceration and had been observed for at least five years after their operation, was collected over a period of four years. These were subdivided into three groups according to the nature of their surgical treatment (see Results). In addition, a control series comprising 220 men, who had originally presented with simple pneumoconiosis at least 10 years previously, was also studied.All radiographs had been categorized by at least two members of this Panel. Simple pneumoconiosis was classified as category 1, 2, or 3 (ILO, 1959), depending on the extent and density of opacities whose greatest diameter was less than 1 cm or as PMF when the opacities had a greatest diameter of at least 1 cm. All these men had worked under approved dust conditions (Bedford and Warner, 1943; National Coal Board,1965) or had left the industry since certification. 45 on 9 May 2018 by guest. Protected by copyright.

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“…In addition, R F has been found in coalminers with PMF not characteristic of Caplan's syndrome [Caplan et al, 1962;Wagner and McCormick, 19671. Lindars and Davies [1967] suggested that a gradation might exist between Caplan's syndrome and typical PMF, ie, the lesion formed would depend upon the relative influences of immunological disturbance and dust exposure. Both in this study and the one by Soutar et a1 [1974] the presence of RF was more closely associated with PMF combined with rheumatoid disease; however, for the remaining men, there was little evidence from any of the studies that R F was particularly associated with the development of PMF.…”

Section: Discussionmentioning

confidence: 97%

Autoantibodies in coalminers: Their relationship to the development of progressive massive fibrosis

Boyd¹,

Robertson²,

Davis³

1982

American J Industrial Med

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Sera from 2421 coalminers, representing all the radiological categories of pneumoconiosis, and from 260 healthy blood donors, as controls, were examined for antinuclear factor and rheumatoid factor. Antinuclear factors were present in 21.5% of sera from the controls and in 23.1 % from the coalminers' group. Rheumatoid factor was present in 5.3% of coalminers and as expected occurred particularly in the few men with progressive massive fibrosis who also had rheumatoid disease. The combined prevalence of both factors showed an increase with age at all disease levels and a significant association with pneumoconiosis category only in men older than 60 years. This study provides no evidence that autoantibodies are likely to be of value in detecting men predisposed to the development of massive fibrosis other than those with rheumatoid disease.

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Rheumatoid pneumoconiosis: A study in colliery populations in the East Midlands coalfield

Cited by 23 publications

References 11 publications

Thoracic Manifestations of Collagen Vascular Diseases

Thoracic Manifestations of Collagen Vascular Diseases

Influence of surgery for peptic ulcer on pneumoconiosis and tuberculosis

Autoantibodies in coalminers: Their relationship to the development of progressive massive fibrosis

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