Rheumatoid Neuropathy

Hart, F. Dudley; Golding, J.

doi:10.1136/bmj.1.5186.1594

Cited by 70 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In each instance there were no inflammatory cells associated with the thrombosed vessels. Other workers have reported vasculitis and occlusion of vasa nervorum in rheumatoid arthritis as a feature of generalized vasculitis and suggested that this may be the major cause of the nerve damage (Hart and Golding, 1960;Schmid, Cooper, Ziff, and McEwan, 1961;Scott, Hourihane, Doyle, Steiner, Laws, Dixon, and Bywaters. 1961;Pallis and Scott, 1965).…”

Section: >2mentioning

confidence: 99%

“…EMG also revealed widespread denervation. Hart and Golding (1960) studied the peripheral nerves in five cases of rheumatoid neuropathy at necropsy and found 'demyelination' in only one patient; this was probably axonal degeneration. Areas of segmental demyelination, on the other hand, were found in the nerves of one case of distal sensory neuropathy from the series reported by Pallis and Scott (1965), but no observations were made upon the more severe cases.…”

Section: >2mentioning

confidence: 99%

“…Sural nerve biopsies were taken from three patients in group 1 and from two patients in group 2, and examined by light and electron microscopy. In addition to the nerve fibres, we were able to study the blood vessels supplying the nerves; this is particularly important as previous workers have found evidence of vasculitis in the vasa nervorum in rheumatoid neuropathy (Cruickshank, 1954;Hart and Golding, 1960;Pallis and Scott, 1965).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Rheumatoid neuropathy: a histological and electrophysiological study

1970

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

SUMMARY Peripheral nerves in five patients with rheumatoid neuropathy were examined electrophysiologically and by sural nerve biopsy. There was close correlation between the clinical severity of the disease and the degree of nerve damage found histologically and by EMG. Group 1 patients with a mild distal sensory neuropathy showed varying degrees of axonal degeneration in the large myelinated fibres and some segmental demyelination. Group 2 patients with a severe, rapidly progressive sensori-motor neuropathy had extensive loss of myelinated fibres. In one case all the large fibres had degenerated. The second case had lost both large and small myelinated fibres together with many of the non-myelinated axons. The major nerve damage in both groups appeared to be axonal degeneration but some segmental demyelination was detected. Occlusive vascular disease in the vasa nervorum was considered to be the major cause of the nerve damage. Chamberlain and Bruckner (1970) GROUP 1 A patchy glove and stocking hypoaesthesia and hypoalgesia is characteristic of this group; it is approximately symmetrical, affecting the feet more often than the hands. The onset is insidious, unobtrusive, and often associated with relatively benign rheumatoid arthritis. The sex ratio is that of rheumatoid disease; with nodules and periarticular erosions frequently present. The arthritis in most patients is seropositive, the Rose's titre being only moderate. CASE 1 I.B. is a 70-year-old housewife with a 20-year history of rheumatoid arthritis. Her arthritis is seronegative, erosive, and anodular; there is typical multiple joint involvement.Mrs B. first developed paraesthesiae and hypoalgesia in the hands six years ago; the symptoms gradually increased and now involve the lower limbs. Hypoaesthesia and hypoalgesia are present on the dorsal surface of the right hallux, left hallux, and left second toe; there are sensory changes in the fingers of both hands, but the palmar aspect of the left fourth finger and the dorsal surface of the left thumb are spared. Some sensory loss can be detected in the dorsum of the right hand. The area involved has extended slightly during the last year despite bilateral carpal tunnel decompression in 1966. Although

show abstract

Section: >2mentioning

confidence: 99%

Section: >2mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Rheumatoid neuropathy: a histological and electrophysiological study

1970

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…The occurrence of neuropathy in rheumatoid arthritis is well known (Hart & Golding, 1960;Steinberg, 1960), patients with this complication usually being males with severe seropositive arthritis, a predominantly sensory polyneuritis and involvement of the legs more than the arms. Rapidly ascending polyneuritis such as in this case has not been reported other than in patients previously treated with systemic steroids.…”

Section: Discussionmentioning

confidence: 99%

Ileal Perforation and Acute Peripheral Neuropathy in Rheumatoid Arthritis

Golding

Goodwill

1965

Postgraduate Medical Journal

View full text Add to dashboard Cite

“…Their disease activity was assessed and graded according to the method of Duthie et al (1955). None of these patients had any clinical evidence of a rheumatoid neuropathy, as shown by sensory loss or severe motor weakness (Hart and Golding, 1960;Steinberg, 1960) at the time of the investigation. The activity and range of movement of the neighbouring joint was noted, as was the degree of wasting and power of the selected muscle (power was graded 0-5).…”

mentioning

confidence: 99%