Rheumatoid factor idiotypes in patients with Sjoegren's syndrome.

Chen, Xin; Sugai, Susumu; Nakasaki, Satoshi; Ogawa, Yasuko; Takeshita, S

doi:10.2177/jsci.19.468

Cited by 3 publications

(1 citation statement)

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“…Laboratory predictors of lymphoma development include anemia, lymphopenia, neutropenia [34], low concentrations of complement factor C3 and/or C4, high serum β-2 microglobulin concentrations, low serum IgM concentrations, the disappearance of a previously positive RF antibodies (RFs) [39], and cryoglobulinemia, especially mixed monoclonal cryoglobulinemia (MMC) [40]. In addition, the particular monoclonal anti-idiotypic antibodies (SF 18/2) against monoclonal RFs were markedly related to the monoclonal proliferation of RF anti-idiotypic positive B cells in patients with SS [41]. The monoclonal rheumatoid factor (RF) cross-reactive idiotypes 17109 and G6 have also been correlated with lymphoma development [40].…”

Section: Predictive Risk Factors For Lymphoma Developmentmentioning

confidence: 99%

Possible Mechanisms of Lymphoma Development in Sjogren’s Syndrome

Dong¹,

Chen²,

Yasukawa³

et al. 2013

CIR

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Primary Sjögren’s syndrome (pSS) is a systemic as well as an organ-specific autoimmune disease characterized by lymphocytic infiltration of the glandular epithelial tissue. SS patients have been reported to be at highest risk of developing lymphoproliferative neoplasms, when compared with patients with other rheumatoid diseases. Factors such as cytokine stimulation, environmental factors, viral infection and genetic events as well as vitamin deficiency may contribute to the development of lymphoma. Over the past few decades, numerous efforts have been made to assess the relationship between lymphoma and SS. These include epidemiological surveys, molecular biologic assessments of clonality and well-linked register cohort studies evaluating the predictive value of clinical, laboratory and histological findings. Nevertheless, the mechanisms and factors predictive of lymphoma development in pSS patients remain to be defined. This review summarizes updated knowledge on the incidence of and risk factors for lymphoma development in pSS patients, as well as discussing the most recent findings on the development and treatment of lymphoma in pSS patients and the possible mechanism of lymphoma development.

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