Rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies with hepatitis B and hepatitis C infection: Review

Zengin, Orhan; Yıldız, Hamit; Demir, Zeynep; Dağ, Muhammed Sait; Aydınlı, Musa; Onat, Ahmet Mesut; Kısacık, Bünyamin

doi:10.17219/acem/63095

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…In the present analysis, the medical records of all 572 brucellosis inpatients were collected, of which 466 brucellosis inpatients with arthralgia were selected as study population. We further excluded 5 patients who unwilling to perform RF inspection and 16 patients with diseases that may have a certain effect on RF, including viral hepatitis (9 cases), fatty liver (5 cases), rheumatic fever (1 case) and RA (1 case) [ 22 , 27 – 29 , 31 , 32 ]. And 445 brucellosis patients with arthralgia were eventually involved in this study.…”

Section: Methodsmentioning

confidence: 99%

“…However, elevated RF was also detected in the healthy elderly, as well as in some autoimmune diseases, such as systemic lupus erythematosus and Sjogren’s syndrome [ 23 – 26 ]. Besides, increasing researches shown that RF was positive in some infectious diseases, such as viral hepatitis, acquired immunodeficiency syndrome (AIDS) and tuberculosis [ 21 , 27 – 29 ]. A case-control study evaluating the rheumatologic laboratory markers of 49 brucellosis patients found that 15 (30.6%) patients were RF positive, which was significantly higher than healthy control people [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia

Zhang

et al. 2021

PLoS Negl Trop Dis

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Background Brucellosis is a critical zoonotic disease in the world, it is the non-specific arthralgia that make brucellosis patients easily misdiagnosed as rheumatoid arthritis (RA) in endemic regions. Elevated rheumatoid factor (RF) is an essential indicator of RA, and the RF in brucellosis patients is significantly higher than healthy people. Therefore, this study further explored the distribution of RF and the relevant factors of the RF positivity in brucellosis patients with arthralgia, in order to strengthen the recognition of physicians for brucellosis patients with RF positivity, especially in brucellosis-endemic areas, so as to avoid misdiagnosis and untimely treatment that may lead to malignant outcomes. Methodology and principal findings The medical records of all 572 brucellosis inpatients were collected in the Sixth People’s Hospital of Shenyang, China from 2015 to 2016. After excluding 106 patients without arthralgia, 5 patients who unwilling to perform RF testing and 16 patients with diseases that may affect RF, 445 brucellosis inpatients with arthralgia were involved in this retrospective cross-sectional study. 143 (32.1%) patients with RF >10 IU/ml were classified into the RF positive group, with an average level of 16.5[12.2, 34.7] IU/ml, of which 45 (10.1%) patients were high-positive with RF >30 IU/ml. Multivariate logistic regression model was used to further analyze the relevant factors of the RF positivity and found that age, wrist joint pain and elevated C-reactive protein (CRP) were positively associated with RF positivity, with OR of 1.02 (P = 0.024), 8.94 (P = 0.008) and 1.79 (P = 0.019), respectively. Conclusion The prevalence of positive RF in brucellosis patients with arthralgia was critical, nearly one-third of patients had RF positive. Elderly men brucellosis patients with arthralgia, wrist joint pain and elevated CRP were at high risk of positive RF. It is reminded that physicians should focus on differential diagnosis during clinical diagnosis and treatment, especially in brucellosis-endemic regions.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia

Zhang

et al. 2021

PLoS Negl Trop Dis

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“…нашли эти антитела только у 1 (2 %) из 50 пациентов [37], тогда как O. Zengin и соавт. -у 32,5 % обследованных [26]. РФ был найден примерно у 25 % пациентов с гепатитом, вызванным вирусом гепатита В, причем уже в преджелтушный период, который может длиться до 180 дней.…”

Section: окончание табл 2 еNd Of Tableunclassified

“…При бессимптомном хроническом гепатите В частота выявления РФ IgG, IgM и IgA составляла соответственно 21; 18,8 и 21 % (общая частота серопозитивности по РФ -42,7 %), тогда как АЦЦП были обнаружены только у 1 (0,6 %) из 176 обследованных пациентов [33]. Однако в другом исследовании АЦЦП были найдены у 20,5 % пациентов с гепатитом В [26].…”

Section: окончание табл 2 еNd Of Tableunclassified

Rheumatoid factor and antibodies against cyclic citrullinated peptide in patients without rheumatoid arthritis

Bunchuk¹

2023

Klinicist

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A review of data on the possible causes of an increase rheumatoid factor (RF), antibodies against cyclic citrullinated peptide (ACCP) and antibodies to modified citrullinated vimentin (AMCV) in patients without rheumatoid arthritis (RA) is presented. The possibility of hyperproduction of these autoantibodies before the development of the clinical picture of RA was indicated. It is indicated that ACCP and IgA RF have the greatest prognostic value in terms of the subsequent development of RA. These antibodies are recommended to be additionally determined in diagnostically difficult cases. Data on the sensitivity and specificity of detection of RF, ACCP and AMCV in the diagnosis of RA are summarized. The results of detection of the discussed antibodies in various rheumatic (other than RA) and non-rheumatic diseases are presented in detail. Particular attention is paid to diseases in which increased synthesis of RF, ACCP and AMCV may not be accompanied by clear clinical symptoms (Sjögren’s disease, autoimmune thyroiditis, some chronic infections, silicosis, monoclonal gammopathy, etc.). Recommendations are given for examining patients with “accidentally” identified increase in RF or ACCP.

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“…It is known that, if untreated, some Lyme disease patients can develop RF and chronic arthritis, and late treatment of Borrelia infection does not always result in the resolution of clinical symptoms. The prolonged presence of high levels of IgG and immune complexes in chronic infection/inflammation can provide sufficient levels of stimulation resulting in the development of RF memory B and plasma cells and, in some cases, the development of autoimmune manifestations (Dammacco et al 2016;Alam et al 2017;Zengin et al 2017).…”

Section: Autoantibodies and Rheumatoid Factor In Hcv Infectionmentioning

confidence: 99%

Antibody Responses in Hepatitis C Infection

Law

2020

Cold Spring Harb Perspect Med

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Antibody responses in hepatitis C virus (HCV) have been a rather mysterious research topic for many investigators working in the field. Chronic HCV infection is often associated with dysregulation of immune functions particularly in B cells, leading to abnormal lymphoproliferation or the production of autoantibodies that exacerbate inflammation and extrahepatic diseases. When considering the antiviral function of antibody, it was difficult to endorse its role in HCV protection, whereas T-cell response has been shown unequivocally critical for natural recovery. Recent breakthroughs in the study of HCV and antigen-specific antibody responses provide important insights into viral vulnerability to antibodies and the immunogenetic and structural properties of the neutralizing antibodies. The new knowledge reinvigorates HCV vaccine research by illuminating a new path for the rational design of vaccine antigens to elicit broadly neutralizing antibodies for protection.

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Rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies with hepatitis B and hepatitis C infection: Review

Cited by 5 publications

References 12 publications

Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia

Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia

Rheumatoid factor and antibodies against cyclic citrullinated peptide in patients without rheumatoid arthritis

Antibody Responses in Hepatitis C Infection

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