Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques

Elkan, Ann‐Charlotte; Engvall, Inga-Lill; Cederholm, Tommy; Hafström, Ingiäld

doi:10.1007/s00394-009-0017-y

Cited by 115 publications

(107 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of overweight and obesity patients is common in RA and SLE (14)(15)(16)(17)(18)(19). However, in our study, the prevalence of obesity was not higher in the BD group than in the HC group and general population (25).…”

Section: Discussionmentioning

confidence: 99%

“…Although the etiology of BD is not fully known, immune abnormality is thought to be associated with the development and maintenance of BD (12,13). The prevalence of obesity in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is reported to be higher (14)(15)(16)(17)(18)(19). In RA and SLE, the potential association of obesity with the progression of the diseases has been researched (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Koca¹,

Kara²,

Özgen³

et al. 2017

Eur J Rheumatol

View full text Add to dashboard Cite

Objective: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). Material and Methods:One hundred and forty-three (143) ). In addition to the routine evaluations (fasting blood glucose, lipid profile, and kidney and liver function tests), serum acylated-ghrelin (AG), unacylated-ghrelin (UAG), total ghrelin (TG) and obestatin levels were analyzed. Student's t-test and chi-square test were used for statistical analysis.Results: The prevalence of obesity was relatively lower in the BD group than in the HC group (12.6% vs. 20.5%, p=0.089). Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p<0.001). Serum UAG, TG and obestatin levels were lower in obese BD patients (n=18) than non-obese BD patients (p=0.027, p=0.014 and p=0.001, respectively). Conclusion:The obestatin level was high and the prevalence of obesity was low in the BD group. Moreover, obese BD patients had low obestatin levels. These results suggest that obestatin may protect BD patients from obesity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Koca¹,

Kara²,

Özgen³

et al. 2017

Eur J Rheumatol

View full text Add to dashboard Cite

show abstract

“…BMI is, however, only a proxy measure of body fat, and in RA it does not detect all individuals with increased body fat (3). Thus, for a given body fat content, patients with RA had a significantly lower BMI reduced by approximately 2 kg/m 2 compared to healthy controls (12).…”

Section: Introductionmentioning

confidence: 99%

Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: A long‐term followup from disease onset

Ajeganova

Andersson

Hafström

2012

Arthritis Care & Research

Self Cite

196

158

View full text Add to dashboard Cite

Objective. To determine the association of obesity, defined as a body mass index (BMI) >30 or >28 kg/m 2 or by waist circumference (WC), with disease activity and severity, as well as its relationship to comorbidities in rheumatoid arthritis (RA). 9% at baseline and 15.8% at followup. In multivariable regression, BMI and obesity, defined as a BMI >30 or >28 kg/m 2 , at both inclusion and the time of the survey were independently associated with higher disease activity, fewer patients in sustained remission, higher HAQ score, more pain, and worse general health. Also, BMI and obesity independently conferred to higher odds for being diagnosed with hypertension, diabetes mellitus, and chronic pulmonary disease. Further, BMI and WC were independently associated with angina pectoris/acute myocardial infarction/coronary revascularization. In contrast, none of the examined obesity variables was associated with the prevalence of stroke or transient ischemic attack. Lifestyle changes during the observational period, such as quitting smoking or diet change, had no impact on the outcomes. Conclusion. Obesity was associated with worse RA disease outcomes and a higher prevalence of comorbidities. Body measurements are recommended to improve prediction of the disease course.

show abstract

“…It is therefore evident that the prevalence of malnutrition, according to the criterion of decreased lean mass, is frequently underestimated [5]. The prevalence of RC also varies depending on the gender of the population studied: in patients with RA, it can reach 52% in women and 30% in men [13].…”

Section: Introductionmentioning

confidence: 99%

Rheumatoid Cachexia, a Metabolic Rheumatoid Arthritis Disorder: Pathophysiological Mechanisms, Diagnostic Tools and Current Therapeutic Strategy

Ghozlani¹

2017

EMIJ

View full text Add to dashboard Cite

Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques

Abstract: Rheumatoid cachexia and central obesity were common in patients with RA. Neither BMI nor MNA could detect this properly. There was a good relative agreement between DXA and BIA, but the limits of agreement were wide, which may restrict the utility of BIA in clinical practice.

Cited by 115 publications

References 26 publications

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: A long‐term followup from disease onset

Rheumatoid Cachexia, a Metabolic Rheumatoid Arthritis Disorder: Pathophysiological Mechanisms, Diagnostic Tools and Current Therapeutic Strategy

Contact Info

Product

Resources

About