Rheumatoid cachexia: a clinical perspective

Summers, Gregory D.; Deighton, C.; Rennie, M. J.; Booth, Alison

doi:10.1093/rheumatology/ken146

Cited by 120 publications

(91 citation statements)

References 97 publications

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“…19 In our study, we found a significantly inverse correlation between SMI and HAQ scores of the RA patients. This result was in accordance with the previous studies investigating relationships between body composition and disability or muscle performance in patients with RA.…”

Section: Smisupporting

confidence: 56%

Presarcopenia and its Impact on Disability in Female Patients With Rheumatoid Arthritis

Melikoğlu

2017

Arch Rheumatol

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Objectives:This cross-sectional pilot study aims to investigate presarcopenia in female patients with rheumatoid arthritis (RA) and to evaluate its relationship to the disability assessment. Patients and methods: Forty female patients with RA (mean age 48.3±8.3; range 31 to 66 years) and 40 healthy controls (mean age 46.2±6.9; range 31 to 58 years) matched for age, sex, and body mass index were included. Pain, morning stiffness duration, disease activity score, erythrocyte sedimentation rate, C-reactive protein, and Health Assessment Questionnaire (HAQ) were evaluated. Body compositions were assessed with whole body dual energy X-ray absorptiometry. The appendicular skeletal muscle mass and skeletal muscle mass index (SMI) of RA patients were compared to the controls and possible correlations between SMI, disease characteristics, and HAQ score were investigated. Results: The body mass index values and percentages of obese, overweight, and healthy weight subjects were similar in the patient and control groups. However, appendicular skeletal muscle mass and SMI calculations were significantly lower, and the percentage of presarcopenia was significantly higher in patients with RA (20%) than controls (7%) (p<0.05). Although there was no significant correlation between SMI and other parameters, a significant negative correlation was determined between SMI and HAQ score in patients with RA (p<0.05). Conclusion:We demonstrated lower SMI values and higher presarcopenia ratios in patients with RA than healthy controls. Independent from other disease characteristics, the inverse correlation between SMI and HAQ scores may contribute to understanding of the impact of the process on patient disability.

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Section: Smisupporting

confidence: 56%

Presarcopenia and its Impact on Disability in Female Patients With Rheumatoid Arthritis

Melikoğlu

2017

Arch Rheumatol

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“…Accelerated muscle loss is observed at a higher age (sarcopenia), and in chronic diseases such as cancer and chronic obstructive pulmonary disease, and is collectively referred to as cachexia (20). In patients with RA, several studies, although not all, have shown evidence for a decreased FFM compared to healthy controls (21)(22)(23)(24)(25). In patients with AS, evidence is limited.…”

Section: Discussionmentioning

confidence: 99%

Physical activity and body composition in patients with ankylosing spondylitis

Plasqui

Boonen

Geusens

et al. 2011

Arthritis Care & Research

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Objective. Patients with ankylosing spondylitis (AS) are at risk for accelerated muscle loss and reduced physical activity. Accurate data are needed on body composition and physical activity in this patient group. The purpose of this study was to investigate body composition and objectively assessed physical activity in patients with AS. Methods. Twenty-five AS patients (15 men, mean ؎ SD age 48 ؎ 11 years) were compared with 25 healthy adults matched for age, sex, and body mass index. Body composition was measured using a 3-compartment model based on air-displacement plethysmography to assess body volume and deuterium dilution to assess total body water. The fat-free mass index (FFMI; fat-free mass divided by height squared) and the percent fat mass (%FM) were calculated. Daily physical activity was assessed for 7 days using a triaxial accelerometer and physical fitness with an incremental test until exertion on a bicycle ergometer. Blood samples were taken to determine C-reactive protein (CRP) level and tumor necrosis factor ␣. Results. Accelerometer output (kilocounts/day) showed the same physical activity level for patients and controls (mean ؎ SD 319 ؎ 105 versus 326 ؎ 66). There was no difference in the FFMI or %FM between the patients and controls. Physical activity was positively related to the FFMI (partial R ‫؍‬ 0.38, P ‫؍‬ 0.01) and inversely related to CRP level (R ‫؍‬ ؊0.39, P < 0.01), independent of group. CRP level was inversely related to the FFMI, but the effect was less strong than with physical activity (partial R ‫؍‬ ؊0.31, P ‫؍‬ 0.03). Conclusion. Daily physical activity may help preserve fat-free mass in patients with AS.

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“…Classically cachexia is characterised by a low BMI. Muscle wasting is a common feature of RA but low BMI is uncommon as the fat mass is preserved or even increased (Summers et al, 2008). Hence, RA patients may present with either the classic low BMI cachexia (1-13% of RA population) (Munro & Capell, 1997) or more frequently, the rheumatoid cachexia (10-20% of RA with controlled disease and 38% of patients with active RA) (Engvall et al, 2008, Metsios et al, 2009).…”

Section: Introduction To Inflammatory Diseasementioning

confidence: 99%