Rheumatoid arthritis patients with interstitial lung disease: Clinical, radiological and laboratory characteristics

Samy, Nermeen; Salah, Haitham; Hammoda, Rasha M.

doi:10.1016/j.ejr.2020.08.004

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Our observation is also in line with an Egyptian study where Samy et al evaluated lung function among 160 RA patients and reported RA-ILD in 63.8% of patients. They also reported similar distribution of UIP (60.7%) and NSIP (39.3%) HRCT patterns among these patients [22]. In addition, a comparable frequency of 61.0% has been reported by Wang et al (2015) in Chinese rheumatoid patients [7].…”

Section: Discussionmentioning

confidence: 58%

Frequency of Interstitial Lung Disease in Rheumatoid Arthritis Patients: A Hospital-Based Study

Iqbal¹,

Khan²,

Hassan³

et al. 2022

Cureus

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Introduction: Among various extra-articular manifestations of rheumatoid arthritis (RA), interstitial lung disease (ILD) is the most frequent and concerning manifestation. The reported frequency of RA-associated ILD (RA-ILD) varies in the literature. The objective of the present study was to determine the frequency of ILD in RA patients at a teaching hospital in Rawalpindi.Methods: 175 male and female patients between 18-70 years were enrolled in the study from January 21, 2022, till July 24, 2022. Patients diagnosed with RA were screened for the concomitant presence of ILD (increased pulmonary markings on chest X-rays and total lung capacity ≤ 80%, predicted on pulmonary function tests). In addition, the frequency of RA-ILD was noted and compared across various subgroups of patients based on age, gender, and disease duration.Results: The mean age of the patients was 45.3 ± 11.5 years. The male-to-female ratio was 1:3.1. The mean disease duration was 6.2 ± 3.5 years at the time of presentation. A total of 118 (67.4%) patients were diagnosed with RA-ILD. The frequency of RA-ILD was significantly higher among patients with a prolonged duration of disease, < 5 years vs. ≥ 5 years (59.1% vs. 75.9%; p-value=0.018). Among 118 patients with RA-ILD, usual interstitial pneumonia (UIP) was the most frequent pattern and was noted in 74 (62.7%) patients, followed by nonspecific interstitial pneumonitis (NSIP), which was noted in 44 (37.3%) patients. When compared, there was no statistically significant difference in the frequency of high-resolution CT (HRCT) pattern of RA-ILD across various subgroups of patients based on age (p-value=0.969), gender (p-value=0.934), and duration of disease (p-value=0.881). Conclusion:In the present study, a substantial proportion of RA patients suffered RA-ILD, which warrants routine screening of these patients for undiagnosed pulmonary involvement so that timely identification and anticipated management may improve the outcome of such cases in future clinical practice.

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Section: Discussionmentioning

confidence: 58%

Frequency of Interstitial Lung Disease in Rheumatoid Arthritis Patients: A Hospital-Based Study

Iqbal¹,

Khan²,

Hassan³

et al. 2022

Cureus

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“…For example, the 4 studies47 50–52 which reported Sjogren’s ILD prevalence within China, estimated a 4-fold variation in magnitude (18.6% in 201147 to 78.6% in 2014) 52. Likewise, for RA ILD, there was substantial variation in the reported prevalence in Egypt (0.8% vs 63.7%) 31 32. Among the occupational-related ILDs (figure 2), silicosis was the most explored condition (n=8)).…”

Section: Resultsmentioning

confidence: 99%

Incidence and prevalence of interstitial lung diseases worldwide: a systematic literature review

et al. 2023

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Interstitial lung disease (ILD) is a collective term representing a diverse group of pulmonary fibrotic and inflammatory conditions. Due to the diversity of ILD conditions, paucity of guidance and updates to diagnostic criteria over time, it has been challenging to precisely determine ILD incidence and prevalence. This systematic review provides a synthesis of published data at a global level and highlights gaps in the current knowledge base. Medline and Embase databases were searched systematically for studies reporting incidence and prevalence of various ILDs. Randomised controlled trials, case reports and conference abstracts were excluded. 80 studies were included, the most described subgroup was autoimmune-related ILD, and the most studied conditions were rheumatoid arthritis (RA)-associated ILD, systemic sclerosis associated (SSc) ILD and idiopathic pulmonary fibrosis (IPF). The prevalence of IPF was mostly established using healthcare datasets, whereas the prevalence of autoimmune ILD tended to be reported in smaller autoimmune cohorts. The prevalence of IPF ranged from 7 to 1650 per 100 000 persons. Prevalence of SSc ILD and RA ILD ranged from 26.1% to 88.1% and 0.6% to 63.7%, respectively. Significant heterogeneity was observed in the reported incidence of various ILD subtypes. This review demonstrates the challenges in establishing trends over time across regions and highlights a need to standardise ILD diagnostic criteria.PROSPERO registration number: CRD42020203035.

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“…Subclinical illness is common, and it is uncertain how to treat a patient with abnormalities but no symptoms. 5 , 6 Male sex, old age at the onset of RA, severe RA, and methotrexate therapy had the most excellent chance of progression. 7 …”

Section: Introductionmentioning

confidence: 99%

Screening for Subclinical Interstitial Lung Disease in Rheumatoid Arthritis Patients: Functional and Radiological Methods

Abdelwahab¹,

Shalabi²,

Ghoneim³

et al. 2022

Turk Thorac J

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OBJECTIVE: Interstitial lung disease is the most frequent lung symptom of rheumatoid arthritis and is a significant contributor to morbidity. As a result, the target of this research was to measure the frequency of radiological and functional abnormalities in rheumatoid arthritis patients who did not have any respiratory symptoms. MATERIAL AND METHODS: This study consists of 30 patients diagnosed with rheumatoid arthritis. All involved cases were exposed to entire history taking and clinical examination. All patients were examined by high-resolution computed tomography and pulmonary function tests. Results: According to the computed tomography visual score, 73.3% showed interstitial lung disease. The most common abnormalities were reticular patterns (46.7%) followed by nodular patterns (40%) and septal lines (23.3%). However, 36% of the patients had a normal pulmonary function, while 32% had a small airway affection, 20% had restrictive lung disease, and 12% had obstructive lung disease. A significant association was found between supine expiratory volume and computed tomography visual score. Results showed no association between interstitial lung disease and all lung function test parameters. Conclusion: Subclinical interstitial lung disease is frequent among rheumatoid arthritis patents. A combination of pulmonary function tests with computed tomography is essential to enhance the recognition of subclinical interstitial lung disease as normal pulmonary function alone cannot exclude its presence.

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Rheumatoid arthritis patients with interstitial lung disease: Clinical, radiological and laboratory characteristics

Cited by 6 publications

References 35 publications

Frequency of Interstitial Lung Disease in Rheumatoid Arthritis Patients: A Hospital-Based Study

Frequency of Interstitial Lung Disease in Rheumatoid Arthritis Patients: A Hospital-Based Study

Incidence and prevalence of interstitial lung diseases worldwide: a systematic literature review

Screening for Subclinical Interstitial Lung Disease in Rheumatoid Arthritis Patients: Functional and Radiological Methods

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