Rheumatoid Arthritis–Interstitial Lung Disease–associated Mortality

Olson, Amy L.; Swigris, Jeffrey J.; Sprunger, David; Fischer, Aryeh; Pérez, Evans R. Fernández; Solomon, Josh; Murphy, James D.; Cohen, Marc D.; Raghu, Ganesh; Brown, Kevin K.

doi:10.1164/rccm.201004-0622oc

Cited by 430 publications

(360 citation statements)

References 19 publications

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“…A full description of the methods has been published previously. 16,17 More details may be found in e-Appendix 1. We included in this study fi les from any decedent with "sarcoidosis" in the record axis.…”

Section: Methodsmentioning

confidence: 99%

Increased Risk of Pulmonary Embolism Among US Decedents With Sarcoidosis From 1988 to 2007

Swigris

Olson

Huie

et al. 2011

Chest

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Background: A recently published report from the United Kingdom suggested an association between sarcoidosis and pulmonary embolism (PE). We sought to examine whether this association was present among US decedents with sarcoidosis. Methods: We used data from the National Center for Health Statistics to investigate the association between sarcoidosis and PE among US decedents from 1988 to 2007. Results: From 1988 to 2007, there were 46,450,489 deaths in the United States and 23,679 decedents with sarcoidosis mentioned on their death certifi cates. Among these, 602 (2.54%) had PE mentioned on their death certifi cates, compared with only 1.13% of the background population ( P , .0001 for comparison). The association between sarcoidosis and PE was signifi cant regardless of gender (OR, 2.07; 95% CI, 1.80-2.39; P , .0001 for men and OR, 1.76; 95% CI, 1.59-1.96; P Յ .0001 for women) or race (OR, 1.57; 95% CI, 1.41-1.76; P , .0001 for blacks and OR, 1.87; 95% CI, 1.63-2.14; P , .0001 for whites). Among decedents with sarcoidosis, there was no difference in risk of PE between men and women (2.30% vs 2.54%, x 2 5 1.32, P 5 .25) or between blacks and whites (2.60% vs 2.23%, x 2 5 3.09, P 5 .08). The association between sarcoidosis and PE held regardless of age. Conclusions: Using death certifi cate data from 1988 to 2007, we detected an association between sarcoidosis and PE regardless of gender, race, or age. Further investigation is needed to decipher the mechanisms of this apparent association.

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Section: Methodsmentioning

confidence: 99%

Increased Risk of Pulmonary Embolism Among US Decedents With Sarcoidosis From 1988 to 2007

Swigris

Olson

Huie

et al. 2011

Chest

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“…This burden is quantified in an epidemiologic study by Olson and colleagues (59). They report that, although mortality rates from RA have fallen over the past 2 decades, mortality rates from RA-DPLD have increased; moreover, clinically significant DPLD occurs in nearly 10% of the RA population (59).…”

Section: Connective Tissue Diseasementioning

confidence: 99%

Update in Diffuse Parenchymal Lung Disease 2011

Luckhardt¹,

Müller–Quernheim²,

Thannickal³

2012

Am J Respir Crit Care Med

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“…Clinically significant RA-DPLD occurs in nearly 10% of the RA population (Olson et al 2011). Interstitial Lung Disease (ILD) is the only complication of RA reported to be increasing in prevalence (Bongartz et al 2010).…”

Section: Dpld In Ramentioning

confidence: 99%