Rheumatoid Arthritis in Silica-Exposed Workers

Min, Young-Sun; Kim, Mingi; Ahn, Yeon-Soon

doi:10.3390/ijerph182312776

Cited by 4 publications

(3 citation statements)

References 28 publications

(35 reference statements)

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“… 9 Therefore, although we adjusted for a number of covariates in the multivariable model, possibility of bias from unmeasured confounders exist. However, given that the prevalence of SSc is very low (77.7 per 1 million in Koreans) 25 and the number of Korean workers occupationally exposed to silica is very small (approximately 150,000, accounting for 0.3% of the Korean population), 42 we presume that the influence by these unmeasured confounders is small. Second, as data on the organs involved are not available in the NHIS database, we could not assess whether the lipid profile is associated with a particular manifestation of SSc.…”

Section: Discussionmentioning

confidence: 89%

Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study

Kwon,

Han,

Park

2023

CLEP

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Background and Aims Lipid metabolism is altered in systemic sclerosis (SSc), mediating activation of immune cells and fibroblasts. However, it is unclear whether altered lipid profile is associated with a risk of developing SSc. We aimed to assess the association between lipid profile and risk of incident SSc. Methods From a Korean nationwide database, individuals without SSc who underwent national health check-ups in 2009 were selected and followed-up through 2019. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride were measured on the health check-up date in 2009. Individuals who developed SSc during follow-up were identified. Multivariable Cox models were performed to estimate the risk of incident SSc according to TC, HDL-C, LDL-C, and triglyceride levels, respectively. Results Of the 9,894,996 individuals selected, 1355 individuals developed SSc during a mean follow-up of 9.2 years (incidence rate=1.49 per 100,000 person-years). Levels of TC (adjusted hazard ratio [aHR] 0.959, 95% confidence interval [CI] 0.945–0.974), HDL-C (aHR 0.968, 95% CI 0.950–0.987), LDL-C (aHR 0.968, 95% CI 0.952–0.983) were inversely associated with the risk of incident SSc, whereas no significant association was observed between levels of triglyceride (aHR 1.004, 95% CI 0.998–1.011) and risk of incident SSc. Conclusion Serum levels of TC, HDL-C, and LDL-C were inversely associated with the risk of incident SSc. Our findings provide new insights that altered lipid profile could be considered a non-causal biomarker associated with incident SSc, which could help early diagnosis. The underlying mechanism for this association needs further studies.

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Section: Discussionmentioning

confidence: 89%

Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study

Kwon,

Han,

Park

2023

CLEP

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“…In another study in India conducted by Joseph Anoop in 2017 on 100 patients with rheumatoid disease, the average age of patients was 43.9 ± 11.96), with the disease controlling females by 81%, and the percentage of patients with hypothyroidism was 20% (15% of them were hypothyroidism) [33]. clinical and 5% subclinical hypothyroidism), and TPO antibody was positive in 31% of patients.…”

Section: Discussion and Comparison With International Studiesmentioning

confidence: 97%

Prevalence of Hypothyroidism in Rheumatoid Arthritis and its Correlation with Disease Activity

2023

BSCR

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Background: Several recent studies have shown an increased incidence of hypothyroidism in many chronic in ammatory diseases, especially rheumatoid arthritis, and others studies have shown a relationship between hypothyroidism in patients with rheumatoid disease and the degree of disease activity. Aim of the Study: To know the extent of hypothyroidism in a sample of patients with rheumatoid arthritis in Al-Assad and Al-Mowasat University Hospital in Damascus, to link this to the effectiveness of rheumatoid disease, and to compare with a group of healthy controls. Materials and Methods: A cross-sectional/case-control study was conducted on 134 patients diagnosed with rheumatoid arthritis, and a healthy cohort of 134 people from the University Hospitals in Damascus. The presence of hypothyroidism was compared between the two groups of patients and controls. Hypothyroidism in patients was also compared with the disease activity index, after dividing them according to the effectiveness index (DAS28-ESR) into three groups: mild, moderate, and severe disease activity. The data was analyzed using the statistical analysis program (SPSS) version and the variable was considered statistically signi cant when the P-Value is less than (0.05) [1]. Results: The average age of both patients and controls was (50.6±3.9) and (44.3±2.01) years, respectively. The proportion of females in the sample of patients was (%84.3) and the percentage of females in the control sample (%80.6), the number of patients with hypothyroidism was 43 patients (%32), and the number of infected controls was 10 people (%7.5) P-Value < 0.000. The type of hypothyroidism in patients was classi ed into clinical hypothyroidism (%67.44) and subclinical hypothyroidism (%32.56). %24.6 of patients and %6 of controls had positive TPO antibodies (P-Value < 0.000). The study has shown a positive correlation between hypothyroidism and disease ecacy indicator (DAS28- ESR). Conclusion: Increased incidence of hypothyroidism and TPO antibodies in patients with rheumatoid disease compared to healthy subjects, and an increase in the degree of disease activity in patients with rheumatoid disease diagnosed with hypothyroidism compared to patients with rheumatoid disease without hypothyroidism.

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“…Certain toxicants have been associated with an increased risk or exacerbation of arthritis. For example, occupational exposure to crystalline silica, commonly found in industries such as mining, construction, and manufacturing, has been linked to an increased risk of developing rheumatoid arthritis [371][372][373][374][375]. It is also possible that prolonged exposure to benzene, a chemical commonly found in industrial settings and certain products such as gasoline, and to vinyl chloride, commonly found in the plastics industry, may also increase the developing of autoimmune diseases, such as arthritis [376,377].…”

Section: Diseases Of the Musculoskeletal Systemmentioning

confidence: 99%

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

Pandics,

Major,

Fazekas-Pongor

et al. 2023

GeroScience

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The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer’s disease, Parkinson’s disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood–brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.

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Rheumatoid Arthritis in Silica-Exposed Workers

Cited by 4 publications

References 28 publications

Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study

Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study

Prevalence of Hypothyroidism in Rheumatoid Arthritis and its Correlation with Disease Activity

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures

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