Rheumatoid arthritis in greek and british patients. a comparative clinical, radiologic, and serologic study

Drosos, Alexandros A.; Lanchbury, Jerry S.; Panayi, G. S.; Moutsopoulos, H M

doi:10.1002/art.1780350705

Cited by 117 publications

(51 citation statements)

References 14 publications

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“…The suppressive eect of low-dose prednisone in early stages of the disease is another explanation for the decrease of CRP and ESR seen in our study. Finally, a possible spontaneous remission of RA may explain these ®ndings, since RA in Greece seems to be milder than that reported in northern European countries [33]. Regarding the radiological progression, our results support those in our previous study and are in agreement with those reported by others [8, 17, 34±36] who showed that CsA can in¯uence radiological disease progression in early RA.…”

Section: Discussionsupporting

confidence: 93%

Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study

Drosos

Katsaraki

et al. 2000

Rheumatology International

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The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg per day) or methotrexate (MTX) (0.15 mg/kg per week). In addition, all patients received prednisone (7.5 mg/day). After 42 months of treatment, pairs of hand and wrist radiographs of 41 patients treated with CsA and 42 treated with MTX were evaluated blindly and separately by two investigators, using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The studied radiographs were obtained at the beginning and 42 months after therapy in both groups. Patients in both groups responded beneficially to the above treatment regimens. In the CsA group, 37 patients (71 %) remained radiographically stable and 4 worsened, while in the MTX group 39 patients (76%) remained stable and 3 deteriorated. No significant radiological worsening was found in the CsA-treated patients as compared to those treated with MTX. Early immuno-intervention in RA patients appears to be crucial for the future development of joint damage: CsA can delay radiological disease progression and may inhibit joint damage deterioration in early RA patients.

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Section: Discussionsupporting

confidence: 93%

Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study

Drosos

Katsaraki

et al. 2000

Rheumatology International

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“…Greeks are known to be one of the most genetically divergent Caucasian subgroups (67) and appear to be phenotypically different from other RA populations, in that they exhibit milder disease (68). For example, in comparison with British patients, RA is less inflammatory and destructive in Greek patients, and the prevalence of extraarticular manifestations (e.g., cutaneous nodules and vasculitis) is notably lower (69). This clinical heterogeneity makes investigation of genetic and environmental differences between eastern Mediterranean and other ethnic groups more interesting.…”

Section: Discussionmentioning

confidence: 99%

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Gorman¹,

Lum²,

Chen³

et al. 2004

Arthritis & Rheumatism

130

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Objective. The strongest known genetic association in rheumatoid arthritis (RA) is with HLA-DRB1 alleles that share a similar amino acid sequence, termed the shared epitope (SE). Although many studies have examined the association of the SE with disease severity, the results have been inconsistent, which may reflect the relatively small sample sizes or ethnic differences. The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-analysis.Methods. We identified English-language articles published between January 1, 1987 and June 1, 1999 through Medline, EMBase, and manual searches of 6 relevant journals. Included were studies in which molecular typing of HLA-DRB1 alleles was performed and in which the presence or absence of bony erosions was reported. Data were extracted from the studies, and erosions were coded as present or absent. Authors were contacted for missing information and data on individual patients.Results. A total of 29 studies and 3,240 patients were available for analysis. The summary odds ratios Conclusion. The SE is associated with the

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“…Studies have shown that RA in Greek patients is much milder and has fewer systemic manifestations than in northern European countries [28]. These dierences could be attributed to the dierent genetic, environmental, and dietary factors [29,30].…”

Section: Discussionmentioning

confidence: 99%

Clinical course and outcome of early rheumatoid arthritis

Katsimbri

Katsaraki

et al. 2001

Rheumatology International

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We studied whether patients with seropositivity in early rheumatoid arthritis (RA) comprise a different clinical group than those with seronegativity. Four hundred seventeen patients with early RA according to the American College of Rheumatology criteria (disease duration less than 1 year) were retrospectively studied by analysis of demographic, clinical, laboratory, radiological, and therapeutic disease characteristics from the time of diagnosis until the end of the study period (1981 1999) using a data base. There were 248 seropositive patients and 169 seronegative patients with RA. No statistically significant differences were seen between the two groups before commencement of the study period in relation to age of disease onset, male:female ratio, and disease duration. However, seropositive patients showed longer medical follow-up. In addition, at disease onset, seropositive RA patients presented more frequently with symmetrical polyarthritis and small joint involvement than seronegative patients. The seropositive group also had more tender and swollen joints, weaker grip strength, and higher erythrocyte sedimentation and C-reactive protein rates during the follow-up period. In contrast, the seronegative group had less severe radiological findings and greater functional ability at the end of the study. In Greek patients with early RA, rheumatoid factor seems to be a predictor of more severe disease activity.

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Rheumatoid arthritis in greek and british patients. a comparative clinical, radiologic, and serologic study

Cited by 117 publications

References 14 publications

Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study

Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study

Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Clinical course and outcome of early rheumatoid arthritis

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