Rheumatoid arthritis associated to HIV infection

Azeroual, A.; Harmouche, H.; Benjilali, L.; Mezalek, Z. Tazi; Mohamed, A.S.R.; Aouni, M.; Maaouni, A.

doi:10.1016/j.ejim.2007.09.020

Cited by 14 publications

(12 citation statements)

References 4 publications

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“…RA associated with HIV infection is quite rare. [ 80 – 82 ] Stein found only 1 case of RA with erosive arthritis in his 58 HIV infected-patient cohort with arthritis. [ 81 ] In Cunha review of the literature, 9 of 198 HIV patients with arthritis presented with a rheumatoid pattern.…”

Section: Discussionmentioning

confidence: 99%

“…[ 82 ] Clinical presentation, biologic features, and radiologic erosions are similar to that observed in HIV-negative patients. [ 80 ] RA usually occurs when immunity is reconstituted by HAART. The role of CD4 T cells in RA pathogenesis is debated but some cases of RA improvement after HIV infection, mediated by a decrease in CD4 T cells, have been described.…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune diseases and HIV infection

et al. 2017

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To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found among 5186 HIV-infected patients which represents a prevalence of 0.69% including immune thrombocytopenic purpura (n = 15), inflammatory myositis (IM) (n = 4), sarcoidosis (n = 4), Guillain–Barré syndrome (GBS) (n = 4), myasthenia gravis (n = 2), Graves’ disease (n = 2), and 1 case of each following conditions: systemic lupus erythematosus, rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis and autoimmune hemolytic anemia. One patient presented 2 ADs. Thirty patients were known to be HIV-infected when they developed an AD. The AD preceded HIV infection in 2 patients. GBS and HIV infection were diagnosed simultaneously in 3 cases. At AD diagnosis, CD4 T lymphocytes count were higher than 350/mm3 in 63% of patients, between 200 and 350/mm3 in 19% and less than 200/mm3 in 19%. Twenty patients benefited from immunosuppressant treatments, with a good tolerance.ADs during HIV infection are uncommon in this large French cohort. Immune thrombocytopenic purpura, sarcoidosis, IM, and GBS appear to be more frequent than in the general population. Immunosuppressant treatments seem to be effective and well tolerated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autoimmune diseases and HIV infection

et al. 2017

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“…It seems that most cases developed at a minimally advanced stage of HIV disease, i.e. with CD4+ counts >200 cells/mm3, and/or when there was an undetectable viral load [16,39,44]. Rheumatoid arthritis arising as an immune reconstitution syndrome has also been described [36,45].…”

Section: Inflammatory Arthritis and Hivmentioning

confidence: 99%

“…Certainly, Stein et al found an equal gender distribution amongst their population, despite their relatively male population [28]. The reported average age at diagnosis ranged between 27-58 years [28] with a range of duration of cART between 8 months and 9 years [44-45]. In one study, smoking was a common risk factor with 50% of those developing RA being cigarette smokers.…”

Section: Inflammatory Arthritis and Hivmentioning

confidence: 99%

Evolving spectrum of HIV-associated rheumatic syndromes

Fox

Walker‐Bone

2015

Best Practice & Research Clinical Rheumatology

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At the end of 2013, 35 million people worldwide were infected with HIV. The prognosis of HIV has been transformed by combination antiretroviral therapy (cART). Providing compliance is good, the use of cART has normalised the life expectancy of HIV-infected people leading to a growing population of people with chronic infection. Management of HIV patients has therefore needed to adapt in order to not only control viral activity but also manage long-term complications of HIV and cART. Rheumatological manifestations of HIV were first described in 1989. Since then, there have been case reports, case series and epidemiological studies describing different clinical manifestations of HIV in the musculoskeletal system. This review will encompass musculoskeletal pain, fibromyalgia, systemic lupus erythematosus (SLE) and inflammatory arthritis in HIV. We will aim to report on the prevalence of these conditions and the risk factors, explore the impact of the virus on the clinical presentations and discuss implications for diagnosis and management.

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“…In advanced HIV infection, there is decreased TNF, interleukin-1 (IL-1), and IFNg production, with increased IL-4 and IL-10 production, which can diminish the activity of RA and SLE. Treatment with highly active antiretroviral therapy (HAART) results in a diminishing number of HIV viruses and increasing number of CD4þ T cells, thus restoring the immune system and exacerbating RA and SLE [96,97]. Conversely, the use of IMDs can lead to the exacerbation of underlying HIV infection [97].…”

Section: Human Immunodeficiency Virusmentioning

confidence: 99%

Treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases

Louthrenoo

2015

Best Practice & Research Clinical Rheumatology

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Rheumatoid arthritis associated to HIV infection

Cited by 14 publications

References 4 publications

Autoimmune diseases and HIV infection

Autoimmune diseases and HIV infection

Evolving spectrum of HIV-associated rheumatic syndromes

Treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases

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