IntroductionRheumatoid Arthritis (RA) is an autoimmune systemic multidisciplinary disease that affects 1 % of the general population [1]. The aetiology of this disease, which results in joint destruction, is characterized by chronic inflammation, progresses cumulatively, negatively affects many systems of the body, and is three times more common in women than in men [2]. Some factors such as genetic, environmental, age and gender are crucial in its progression [3]. The disease can be diagnosed by increasing inflammatory biomarkers in the inflamed synovium and distinguished from other types of arthritis [4]. Together with the earth-shaking COVID-19 outbreak that started in Wuhan, China in December 2019, some biomarkers in RA have become crucial [4,5]. The most popular markers (IL-6) that shed light on the progression and pathology of the disease are markers such as Interleukin-6, ACPA, and anti-CCP. In rheumatoid arthritis disease, inflammation shows a substantial increase [4].
Aetiology and Pathology of Rheumatoid ArthritisAlthough the aetiology of RA is not known exactly, it occurs in different clinical pictures that are considered to be involved in infection, genetic, environmental, and endocrine dysregulation [3]. Inflammation of the synovium is a pathological event that destroys articular cartilage and bone. The most crucial condition