Rheumatoid Arthritis

Short, Charles L.; Bauer, Walter; Reynolds, William E.

doi:10.4159/harvard.9780674423947

Cited by 196 publications

(41 citation statements)

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“…There is a long-recognized influence of pregnancy on the activity of rheumatoid arthritis (RA), with a reduction in inflammatory activity during pregnancy and a "relapse" afterwards (1)(2)(3). There may be a physiologic explanation for this phenomenon given the antiinflammatory activity of some of the proteins produced by the body during pregnancy (4).…”

Section: Timing Of Pregnancy In Relation To the Onset Of Rheumatoid Amentioning

confidence: 99%

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

Silman

Kay

Brennan

1992

Arthritis & Rheumatism

220

112

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The interval between the onset of rheumatoid arthritis (RA) and the most recent pregnancy prior to RA onset in 88 women was determined. These data were compared with data obtained from a group of 144 age-matched normal women (controls) who had been assigned a "dummy date for RA onset" for the purposes of analysis. The frequency of disease onset during 3 time intervals within the period from conception to 1 year postpartum was compared with the frequency of disease onset outside this period. There was a reduction in the incidence of disease onset during pregnancy (adjusted odds ratio [OR] 0.30, 95% confidence interval [CI] 0.W2.6) and a numerically greater increased risk of RA onset during the first 3 months postpartum (OR 5.6, 95% CI 1.8-17.6), which persisted for the subsequent 9 months (OR 2.6, 95% CI 0.8-7.9). A reduction in the incidence of disease onset was seen during all pregnancies; in contrast, the postpartum increase was greater in those with RA onset after the first pregnancy. The reduced incidence of RA onset during pregnancy, with the increased risk postpartum, mirrors the previously described suppression of disease activity during preg nancy and the subsequent flare postpartum in women with established RA. In addition, the increased postpartum risk after the first pregnancy might suggest that in susceptible women, either the hormonal changes or the

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Section: Timing Of Pregnancy In Relation To the Onset Of Rheumatoid Amentioning

confidence: 99%

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

Silman

Kay

Brennan

1992

Arthritis & Rheumatism

220

112

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“…A further abnormality of SLE is the presence of circulating immune complexes [24]. Rheumatoid arthritis is a chronic, systemic inflammatory disorder characteristi~lly involving peripheral joints [25]. The aetiology is unknown but there is accumulating evidence that a factor on the D locus of the sixth chromosome (DR4/Dw4&Dw 14) occurs in a significantly high number of sero-positive cases [26,27].…”

Section: D~cu~ionmentioning

confidence: 99%

8‐Hydroxydeoxyguanosine

Lunec

Herbert

Blount³

et al. 1994

FEBS Letters

129

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Abstract8-Hydroxydeoxyguanosine (80HDG) is a specific marker of oxidative damage to DNA. We have observed that patients with SLE (systemic lupus erythematosus), have undetectable levels of urinary 8OHDG by HPLC. Further analysis by GC-MS confirmed that levels of 80HDG in SLE urine were lo'-fold lower than in an age-and sex-matched control group. Experiments utilising cultures of SLE and normal lymphocytes exposed to H,O, confirmed the impaired ability of SLE lymphocytes to repair 80HDG. We subsequently observed in SLE patients that 8OHDG had accumulated in low molecular weight DNA associated with circulating immune complexes. We suggest that oxygen radicals may induce pathology in SLE by maintaining the presence of an antigenic form of DNA in the circulation.

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“…Some authors indicated low incidence of heart involvement in patients with rheumatoid arthritis (Gil 1949, Egelius et al 1955, Koda 1956, Short et al 1957), and others reported higher incidence (Fischman and Gwynne 1948, Bradfield andHijtmancik 1950, Schneller 1950). As for the autopsied cases, the incidence of the heart lesions was reported to be relatively high (Baggenstoss and Rosenberg 1941, Bywaters 1950, Egelius et al 1955, Levin et al 1955.…”

Section: Considerablementioning

confidence: 99%

Clinical Observation on the Heart Involvement in Rheumatoid Arthritis

Asai

1962

Jpn Heart J

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Rheumatoid Arthritis

Cited by 196 publications

References 0 publications

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

8‐Hydroxydeoxyguanosine

Clinical Observation on the Heart Involvement in Rheumatoid Arthritis

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