Rheumatic disorders — clues to occult neoplasia

Naschitz, Jochanan E.; Yeshurun, Daniel; Rozenbaum, M.; Rosner, Inger L.

doi:10.1016/s0753-3322(96)89724-1

Cited by 18 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The clinical features of RSDinclude pain and swelling in the distal extremity, dystrophic skin changes, hand contractures, and vasomotor or sudomotor disturbances (22). PFAdiffers from RSD in that the fasciitis is more severe, arthritis is more inflammatory, and both processes are more rapidly progressive than in RSD (23). Furthermore, there are no vasomotor or sudomotor disturbances in PFA.…”

Section: Discussionmentioning

confidence: 99%

Palmar Fasciitis and Polyarthritis Associated with Gastric Carcinoma. Complete Resolution After Total Gastrectomy.

et al. 2000

View full text Add to dashboard Cite

Palmar fasciitis and polyarthritis (PFA) is a rare paraneoplastic rheumatic syndromecharacterized by flexion contractures of both hands and thickening of palmar fascia. Several reports have suggested that this syndrome is a tumor-associated autoimmunedisorder. Wereport a 44-year-old Japanese man who presented with flexion contractures of both hands associated with thickening of palmar fascia and polyarthritis. These clinical pictures were suggestive of PFA associated with occult neoplasm. Upper gastrointestinal endoscopic examination revealed advanced gastric cancer. Resection of the cancer resulted in a gradual resolution of palmar fasciitis and polyarthritis. This clinical course Suggests an underlying tumor-related immunologic process in this syndrome. (Internal Medicine 39: 754-757, 2000)

show abstract

Section: Discussionmentioning

confidence: 99%

Palmar Fasciitis and Polyarthritis Associated with Gastric Carcinoma. Complete Resolution After Total Gastrectomy.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14] In the present case, the patient had sinusitis and the titer of PR3-ANCA was high, but the histology demonstrated small vessel vasculitis without granu- There are only five such cases with a definitive diagnosis of vasculitis confirmed by biopsy reported in the literature (Table 1). 6,[16][17][18] Two cases were positive for MPO-ANCA or p-ANCA, and three cases were positive for PR3-ANCA or c-ANCA.…”

Section: Discussionmentioning

confidence: 47%

Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy

Tsuda

Nakashima

Ikeda

et al. 2015

J Clin Exp Hematopathol

View full text Add to dashboard Cite

A 64-year-old woman had suffered from painful livedo reticularis for 2 years and was referred to us due to fever, anasarca and paresthesia of the lower limbs. Serum proteinase-3-anti-neutrophil cytoplasmic antibody (ANCA) was positive. Abnormal lymphocytes were found in the cerebrospinal fluid and bone marrow. Skin biopsy revealed large atypical lymphoid cells with CD20 positivity lodged in the small vessels and neutrophilic infiltration into the arterial vascular wall with fibrinoid degeneration. A diagnosis of intravascular large B-cell lymphoma complicated by ANCA-associated vasculitis was made, and rituximabcontaining chemotherapy followed by prednisolone was quite effective for both lymphoma and ANCA-associated vasculitis. 〔J Clin Exp Hematop 55(1) : 39-43, 2015〕

show abstract

“…[18] Naschitz et al, found circulating ANA in 30% of patients with cancer, some of whom developed autoimmune disorders. [19] Analyzing differences in the patterns of nuclear staining of ANA and their antigenic specificities, it has been found that ANA in the aged are persistent and directed toward chromatin elements, sharing major histocompatibility complex (MHC) associations with autoimmune diseases. [14] Furthermore, ANA were found associated with anticardiolipin (aCL) antibodies, [20] these are positive in 28% of the elderly patients studied.…”

Section: Autoimmune Diseases In the Elderlymentioning

confidence: 99%

Autoimmunity in the elderly: Implications for cancer

et al. 2012

View full text Add to dashboard Cite

Immunosenescence is the aging process involving the immune system competencies. These changes imply a reduced level of immunosurveillance against cancer onset and the occurrence of autoimmune phenomena. The clinical presentation of autoimmune diseases in the elderly is characterized in most cases by atypical features, insidious presentation and poor specificity of laboratory parameters. The role of autoimmune reactivity in the elderly either as a consequence of or as a risk factor for cancer development has aroused great interest among clinicians and researchers, as well as the influence of a chronic inflammatory state as a predisposing factor for autoimmunity and cancer occurrence. Particularly, we have investigated the pathogenetic effect of two cell subsets, Treg cells and Th17 lymphocytes, involved in the control mechanisms both of autoimmune reactions and cancer onset, as the possible future approach to treat cancer in older adults.

show abstract

Rheumatic disorders — clues to occult neoplasia

Cited by 18 publications

References 0 publications

Palmar Fasciitis and Polyarthritis Associated with Gastric Carcinoma. Complete Resolution After Total Gastrectomy.

Palmar Fasciitis and Polyarthritis Associated with Gastric Carcinoma. Complete Resolution After Total Gastrectomy.

Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy

Autoimmunity in the elderly: Implications for cancer

Contact Info

Product

Resources

About