Rheum officinale (a traditional Chinese medicine) for chronic kidney disease

Abstract

In Taiwan, chronic kidney disease (CKD) is highly prevalent and traditional Chinese medicine (TCM) is one of the most commonly used complementary medicines. To date, little information is available on the utilization patterns for TCM among CKD patients, particularly those with late stage CKD. We conducted a cross-sectional hospital-based study to investigate this issue. In this study, late stage CKD patients were identified by ICD-9-CM codes: 585 and 586, and only CKD stage 3b, 4 and 5 patients were included in the analysis. Clinical information was retrieved from the electronic medical records database from January, 1, 2006 to December, 31, 2011. Among a total of 8,459 patients, 408 TCM users and 8,051 non-TCM users were identified and their data were analyzed. We found that TCM users were almost four times more likely to be older than 55 years than non-TCM users, after controlling for the other covariates (adjusted odds ratio [aOR]: 3.98, 95% confidence interval [CI]:[2.33, 6.81]). They were also less likely to have diabetes (aOR: 0.48), hypertension (aOR: 0.62) or gout (aOR: 0.62). Among all disease conditions, late stage CKD patients with neoplasms had the highest tendency to seek TCM treatment compared to non-neoplasm CKD patients (aOR: 5.39, 95% CI: [4.64, 6.26]). Among all TCM users, internal medicine outpatient services (providing CHMs only) is more frequently used than acupuncture/massage outpatient services (3,476 vs. 320 visits). Jia-Wei-Xiao-Yao-San (JWXYS) was the most commonly prescribed Chinese herbal medicine (CHM) for late CKD patients (36.2% of 4,494 prescriptions), followed by Bu-Yang-Huan-Wu-Tang (BYHWT)

Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease

“…It also inhibits the activity of K ATP channel and the ion transport (chloride) across colon cells [ 18 ] due to its laxative effect. Rhubarb, a laxative Chinese medical herb since ancient time, has been widely used to reduce uremic toxins for the treatment of CKD in China [ 19 , 20 ]. But it has been used more often via colonic administration than via oral administration since early 1950s [ 21 ].…”

Efficacy and Safety of Tangshen Formula on Patients with Type 2 Diabetic Kidney Disease: A Multicenter Double-Blinded Randomized Placebo-Controlled Trial

“…Multicenter randomized controlled clinical trials have shown that CHM therapy improves estimated glomerular filtration rate (eGFR) in both patients with stage 3chronic kidney disease (CKD) and idiopathic membranous nephropathy [ 13 , 14 ]. Many CHM preparations have been used in treating CKD in China, and systematic reviews have shown that some are effective [ 15 , 16 ]. Investigations on CHM treatment of DKD have been undertaken in China.…”

Preliminary study of the mechanism underlying how Jianshen Granules ameliorate renal failure in 5/6 nephrectomy model rats

“…Based on TCM theory, renal failure is due to "deficient functioning of the spleen and kidney", "interior accumulation of dampness and turbidity", and "accumulated poison gathered in the kidney". It is characterized as one of the "consumptive diseases" [8]. Center on 61 patients with CRF revealed that the overall response rate of Jianshen Granules was 85.24%.…”