Rhesus Negative Woman Transfused With Rhesus Positive Blood: Subsequent Normal Pregnancy Without Anti D Production

Maya, Ernest; Buntugu, KA; Pobee, F; Srofenyoh, EK

doi:10.4314/gmj.v49i1.11

Cited by 4 publications

(3 citation statements)

References 17 publications

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“… 29 30 Individuals who are Rh negative produce anti-D if they are transfused with blood which is Rh positive. 31 The proportion of blood donors in the present study with Rh negative was 4.7% still low when compared with 2% which was reported in Tanzania from a study which had a sample size of 1845 blood donors which is quite insignificant when compared with 65 535 blood donors in the current study. Studies have shown that the incidence of Rh negative may stand up to 17% globally.…”

Section: Discussioncontrasting

confidence: 70%

Frequency and distribution of ABO and Rh blood group systems among blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania: a retrospective cross-sectional study

et al. 2023

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ObjectivesABO and Rh blood group systems are the major factors affecting the blood transfusion safety. The frequency and distribution of these blood group systems vary worldwide. We aimed to determine the frequency and distribution of ABO and Rh blood group systems among first-time blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania.DesignCross-sectional descriptive population-based study.SettingData on ABO and Rh blood group systems were obtained and analysed from the Northern Zone Blood Transfusion Center among first-time blood donors.ParticipantsThere were 65 535 first-time blood donors aged 15–55 years who donated at the Northern Zone Blood Transfusion Center from January 2017 to December 2019.Outcome measuresThe percentage of ABO and Rh blood group systems among different categories of blood donors was calculated.ResultsRetrospective data from Blood Establishment Computer System of 65 535 first-time blood donors were analysed in the present study. The mean age of the blood donors was 30.6±11.2 years (range: 15–55 years). The vast majority of the blood donors 84.2% (n=55 210) were men. Also, the majority 69.6% (n=45 595) were aged ≥35 years. Blood group O was the most common blood group which was found in over half 52.4% (n=34 333) of the blood donors and majority 95.3% (n=62 461) of the donors were Rh positive. Moreover, the majority 78.3% (n=51 336) were voluntary donors and the remaining 21.7% (n=14 199) were replacement donors.ConclusionMajority of the donors had blood group O and also the vast majority of the donors were Rh positive. Considering the large size of our study population, this has provided a more comprehensive information regarding the frequency and patterns of ABO and Rh blood group systems in Tanzania. The observed association of blood group A with one of the regions from which donors were coming from, is intriguing and further studies may confirm possible related genetic evolution.

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Section: Discussioncontrasting

confidence: 70%

Frequency and distribution of ABO and Rh blood group systems among blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania: a retrospective cross-sectional study

et al. 2023

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“…Solving the age-long controversies on anti-HBc inclusion or exclusion in HBV screening for blood transfusion/organ transplant requires multiple strategies. Firstly, optimal blood donor selection methods that promote 100% voluntary non-remunerated blood donation according to vision 2020 set by the World Health Organization [43,44] and reverse the current trend of 30%, 60% and 10% replacement, commercial and voluntary blood donations respectively [45] should be adopted in Nigeria.…”

Section: Optimal Donor Selection Methodsmentioning

confidence: 99%

Isolated serum hepatitis B core antibody seropositivity: A diagnostic risk factor for occult hepatitis B infection

Fasakin

Ifeanyichukwu

Ibijola

et al. 2019

ISBT Science Series

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Anti‐HBc screening and nucleic acid testing for hepatitis B viral DNA (HBV DNA) detection in blood donors are not routinely performed in clinical settings in Nigeria. This raises serious concerns for safety of blood at a time that global health standards advocate for transfusion safety. The aim of this research is to investigate if presence of anti‐HBc in blood donors is actually associated with occult hepatitis B infection through basic and advanced procedures. Prospective blood donors who were seronegative for HBsAg but sero‐positive for anti‐HBc (with or without other markers) among the four hundred and seventy enrolled in a cross‐sectional study were selected for this study. Samples were further screened for hepatitis B core immunoglobulin M by enzyme‐linked immunosorbent assay. Nucleic acid testing was performed for confirmation of occult hepatitis B infection. Anti‐HBc was detected in 20 (32.8%) of the sixty‐one HBsAg antigen‐negative blood donors which constituted 13.0% of the total number of enrolled blood donors. Anti‐HBc total‐positive differentiation showed eighteen (90.0%) anti‐HBc (IgG) and two (10%) anti‐HBc (IgM) were detected. Nucleic acid testing showed 5.0% prevalence of occult hepatitis B infection among the anti‐HBc‐positive blood donors with estimated HBV DNA viral load of 58 IU/ml. Demonstration of 5.0% occult hepatitis B prevalence showed the possibility of post‐transfusion hepatitis B infection in transfusion recipients with consequent possible liver damage should hepatitis B surface antigen alone be the continued practice in clinical settings. The inclusion of antibody to hepatitis B core antigen screening in addition to hepatitis B surface antigen marker is an essential step to ensuring optimal blood safety and prevent post‐transfusion hepatitis.

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“…Also, for those quite remote from the term, conservative management may be instituted after the initial surgical intervention. 26 Despite the low rate of successful post-SHiP pregnancy continuation, patients should be made aware of the possibility of miscarriage, recurrence of SHiP during the index and subsequent pregnancy. 11 Also, the possibility of an emergency surgical intervention should be discussed with the patient.…”

Section: Management Strategiesmentioning

confidence: 99%

Spontaneous haemoperitoneum in pregnancy in women with endometriosis: Diagnostic challenges and management strategies

Mamah,

Ruth Otu,

Okafor

et al. 2024

SAGE Open Medicine

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Spontaneous haemoperitoneum in pregnancy is a rare but potentially life-threatening condition that requires prompt recognition and management to avert a catastrophic outcome for the mother and baby. The main aim of this review is to summarise the current knowledge on this topic, including its incidence and clinical presentation, highlight the diagnostic challenges, and suggest management strategies. To achieve our objective, we examine the existing literature to provide insights into this complex clinical presentation to enhance our understanding and, in so doing, contribute to the existing body of knowledge on the subject of spontaneous haemoperitoneum in pregnancy.

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Rhesus Negative Woman Transfused With Rhesus Positive Blood: Subsequent Normal Pregnancy Without Anti D Production

Cited by 4 publications

References 17 publications

Frequency and distribution of ABO and Rh blood group systems among blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania: a retrospective cross-sectional study

Frequency and distribution of ABO and Rh blood group systems among blood donors at the Northern Zone Blood Transfusion Center in Kilimanjaro, Tanzania: a retrospective cross-sectional study

Isolated serum hepatitis B core antibody seropositivity: A diagnostic risk factor for occult hepatitis B infection

Spontaneous haemoperitoneum in pregnancy in women with endometriosis: Diagnostic challenges and management strategies

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