Rheology of blood coagulation

Kaibara, Makoto

doi:10.1016/0006-355x(96)00010-8

Cited by 33 publications

(27 citation statements)

References 45 publications

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“…Reference [162] discusses the relationship between the rheology of the blood and the stages of blood clotting. Reference [12] and stain formation [163,164].…”

Section: Fluid Dynamics Descriptionmentioning

confidence: 99%

“…Area of Convergence, Directionality [13] [ 5,97] Area of Origin [13,19,68 Backspatter Pattern; Forward Spatter Pattern area of origin, weapon [48] [5, 47,110,191] Blood Clot [6,162] [ 160 , 162] Bloodstain pattern area of origin, weapon [13,35,76 [ 166,170,196] Perimeter Stain time between drip and wipe-off, [155,197,198] [ 155,188] [188] [155,163,197,198] Flow Pattern [12,162,199] [12, 162,185,199] [185] [12] Impact Pattern weapon, motion; directionality [78][79][80]128] [5] [72,128,136] Insect Stain [157,200] Mist Pattern weapon, directionality [81, 154 , 186 Spatter Stain [201] [126, [15...…”

Section: Mixingmentioning

confidence: 99%

See 1 more Smart Citation

Fluid dynamics topics in bloodstain pattern analysis: Comparative review and research opportunities

Attinger

Moore

Donaldson

et al. 2013

Forensic Science International

154

139

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This comparative review highlights the relationships between the disciplines of bloodstain pattern analysis (BPA) in forensics and that of fluid dynamics (FD) in the physical sciences. In both the BPA and FD communities, scientists study the motion and phase change of a liquid in contact with air, or with other liquids or solids. Five aspects of BPA related to FD are discussed: the physical forces driving the motion of blood as a fluid; the generation of the drops; their flight in the air; their impact on solid or liquid surfaces; and the production of stains. For each of these topics, the relevant literature from the BPA community and from the FD community is reviewed. Comments are provided on opportunities for joint BPA and FD research, and on the development of novel FD-based tools and methods for BPA. Also, the use of dimensionless numbers is proposed to inform BPA analyses. Keywordsbloodstain pattern analysis, review, dimensionless number, drop generation, trajectory, impact, stain Disciplines Laboratory and Basic Science Research | Other Mechanical EngineeringComments NOTICE: this is the author's version of a work that was accepted for publication in Forensic Science International. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Forensic Science International, [231, 1-3, (2013) Abstract: This comparative review highlights the relationships between the disciplines of bloodstain pattern analysis (BPA) in forensics and that of fluid dynamics (FD) in the physical sciences. In both the BPA and FD communities, scientists study the motion and phase change of a liquid in contact with air, or with other liquids or solids. Five aspects of BPA related to FD are discussed: the physical forces driving the motion of blood as a fluid; the generation of the drops; their flight in the air; their impact on solid or liquid surfaces; and the production of stains. For each of these topics, the relevant literature from the BPA community and from the FD community is reviewed. Comments are provided on opportunities for joint BPA and FD research, and on the development of novel FD-based tools and methods for BPA. Also, the use of dimensionless numbers is proposed to inform BPA analyses.

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“…Reference [162] discusses the relationship between the rheology of the blood and the stages of blood clotting. Reference [12] and stain formation [163,164].…”

Section: Fluid Dynamics Descriptionmentioning

confidence: 99%

Section: Mixingmentioning

confidence: 99%

Fluid dynamics topics in bloodstain pattern analysis: Comparative review and research opportunities

Attinger

Moore

Donaldson

et al. 2013

Forensic Science International

154

139

View full text Add to dashboard Cite

show abstract

“…A key mechanism in the coagulation process involves the conversion of fibrinogen into insoluble stands of fibrin through catalytic action of the protease thrombin. This is followed by subsequent fibrin cross-linking and platelet adhesion leading to the formation of a platelet-fibrin mesh which increases the viscoelastic modulus of clotting blood [11]. As a result, by measuring changes in the viscoelastic properties of blood, clotting time can be assessed, which is an important indicator of the patient's coagulation status.…”

Section: Introductionmentioning

confidence: 99%

Assessing blood coagulation status with laser speckle rheology

Tripathi

Hajjarian

Cott

et al. 2014

Biomed. Opt. Express

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Abstract:We have developed and investigated a novel optical approach, Laser Speckle Rheology (LSR), to evaluate a patient's coagulation status by measuring the viscoelastic properties of blood during coagulation. In LSR, a blood sample is illuminated with laser light and temporal speckle intensity fluctuations are measured using a high-speed CMOS camera. During blood coagulation, changes in the viscoelastic properties of the clot restrict Brownian displacements of light scattering centers within the sample, altering the rate of speckle intensity fluctuations. As a result, blood coagulation status can be measured by relating the time scale of speckle intensity fluctuations with clinically relevant coagulation metrics including clotting time and fibrinogen content. Our results report a close correlation between coagulation metrics measured using LSR and conventional coagulation results of activated partial thromboplastin time, prothrombin time and functional fibrinogen levels, creating the unique opportunity to evaluate a patient's coagulation status in real-time at the point of care. (2013). 11. M. Kaibara, "Rheology of blood coagulation," Biorheology 33(2), 101-117 (1996). 12. C. E. Dempfle, T. Kälsch, E. Elmas, N. Suvajac, T. Lücke, E. Münch, and M. Borggrefe, "Impact of fibrinogen concentration in severely ill patients on mechanical properties of whole blood clots," Blood Coagul.

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“…Two primary physical changes occur within the vessel lumen during thrombus formation: cross-sectional area available for blood flow decreases and blood viscosity increases as the blood coagulates, [13][14][15][16] both of which lead to increased resistance to blood flow. According to the electrical circuit analogy for Poiseuille's law, which assumes the ideal case of laminar flow of a Newtonian fluid through a tube, resistance to flow is given by the following equation: (1) where R is resistance to flow, l is fluid viscosity, A available is the cross-sectional area available for flow (neglecting potential porous flow through clots for simplicity), and L is the length of the tube contacting the fluid.…”

Section: Introductionmentioning

confidence: 99%

Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure

Nichols

Choudhary

Kodali

et al. 2013

J. Biomed. Mater. Res.

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In this study, the coagulation-induced resistance to flow in small-diameter nonpermeable Tygon tubes and permeable expanded polytetrafluoroethylene (ePTFE) vascular grafts was characterized by measuring the upstream pressure needed to purge the coagulum from the tube lumen. This purging pressure was monitored using a closed system that compressed the contents of the tubes at a constant rate. The pressure system was validated using a glycerin series with well-defined viscosities and precisely controlled reductions in cross-sectional area available for flow. This system was then used to systematically probe the upstream pressure buildup as fibrin glue, platelet-rich plasma (PRP) or whole blood coagulated in small-diameter Tygon tubing and or ePTFE grafts. The maximum purging pressures rose with increased clot maturity for fibrin glue, PRP, and whole blood in both Tygon and ePTFE tubes. Although the rapidly coagulating fibrin glue in nonpermeable Tygon tubing yielded highly consistent purging curves, the significantly longer and more variable clotting times of PRP and whole blood, and the porosity of ePTFE grafts, significantly diminished the consistency of the purging curves.

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Rheology of blood coagulation

Cited by 33 publications

References 45 publications

Fluid dynamics topics in bloodstain pattern analysis: Comparative review and research opportunities

Fluid dynamics topics in bloodstain pattern analysis: Comparative review and research opportunities

Assessing blood coagulation status with laser speckle rheology

Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure

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