Rheology in Pharmaceutical Formulations-A Perspective

Mastropietro, David J; Nimroozi, Rashel; Omidian, Hossein

doi:10.4172/2329-6631.1000108

Cited by 37 publications

(20 citation statements)

References 13 publications

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“…The revelation of this study and related study from Khaled & Abdelbaki, (2012) affirm that Na-CMC has high affinity for calcium ions, meaning also that it may not be a good suspending agent for formulations containing calcium. It has also been reported (Sultana et al, 2012;Mastropietro et al, 2013) that carboxyl groups of carboxyl-substituted methyl cellulose are particularly sensitive to calcium, aluminium and iron ions. According to the researchers, the complexation of the carboxyl group and calcium ions caused a reduction in medium viscosity, and thus high sedimentation rate.…”

Section: Resultsmentioning

confidence: 77%

Effect of sodium carboxymethylcellulose biopolymer on sedimentation properties of trimagnesium, tricalcium and tristrontium phosphates precipitates

Iboroma¹,

Cookey²,

Obunwo³

2018

Journal of Applied Sciences and Environmental Management

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Sedimentation data of bioactive materials are essential in formulation of suspension with desirable requirements. Batch-wise precipitation and sedimentation tests were conducted to evaluate the effect of sodium carboxymethylcellulose (Na-CMC) biopolymer solution on the sedimentation properties (rate and compaction) of trimagnesium phosphate (TMP), tricalcium phosphate (TCP) and tristrontium phosphate (TSP) precipitates. Fixed volume (1ml) of different concentrations (200ppm -2000ppm) of Na-CMC solution was mixed with fixed volume (50ml) of 0.5M, 0.05M Na3PO4 solutions. Accordingly, the resulting solutions were separately mixed with fixed volumes (50ml) of 0.5M Mg (NO3)2, 0.05M CaCL2 and 0.05M SrCL2 solutions and settling of the precipitates formed monitored. The results showed that whereas for TCP, Na-CMC exhibited a curvilinear relationship with precipitate sedimentation, non-linear relationships were observed for TMP and TSP precipitates. Between 200ppm and 2000ppm of Na-CMC addition, sedimentation rate and compaction of TCP precipitate increased by 187% and 18.5%, whereas for TMP and TSP precipitates, they increased by only (19.89% and 1%) and (30% and 0%), respectively. The results suggest that Na-CMC biopolymer is not the preferred suspending medium for suspension formulations containing TCP. For TMP and TSP precipitates, further study is needed in the light of the fact that magnesium and strontium resemble calcium.

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Section: Resultsmentioning

confidence: 77%

Effect of sodium carboxymethylcellulose biopolymer on sedimentation properties of trimagnesium, tricalcium and tristrontium phosphates precipitates

Iboroma¹,

Cookey²,

Obunwo³

2018

Journal of Applied Sciences and Environmental Management

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“…The rheological behavior of hydrophilic formulations, e.g., lubricants, used in pharmaceutical formulations is crucially important since it will directly affect the pathway of formulation development, the quality of raw and finished product, the components efficiency, the patient's compliance, and the overall healthcare costs (Mastropietro et al 2013). In this work, the developed lubricant formulation was mainly composed by HEC and glycerol to confer the gelling/thickening and lubricating properties required.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase

Gonçalves

Botelho

Teixeira

et al. 2015

Appl Microbiol Biotechnol

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Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxidative enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of trimethoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimethoprim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97% of Escherichia coli and Staphylococcus epidermidis suspensions, respectively (after 24 h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field.

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“….By direct mixing, various degrees of particle concentration were created in the reaction vessel. High particle concentration promotes particle-particle interactions and results in hindered sedimentation (Punnamaraju, 2012;Mastropietro et al, 2013); thus lower sedimentation rate. High temperature also enhances particle-medium interactions (Gary, 2004), which increased the tendency for the particles to remain stabilized at the initial precipitation stages.…”

Section: Methodsmentioning

confidence: 99%

Influence of temperature and ion concentration on sedimentation characteristics of Tricalcium phosphate (TCP) and Tristrontium phosphate (TSP) Precipitates

Obunwo¹,

Iboroma²,

Cookey³

2018

Journal of Applied Sciences and Environmental Management

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Physical and chemical variables of insoluble salts generally affect sedimentation characteristics of precipitates. In this research study, the effects of temperature and ion concentration on the sedimentation of tricalcium phosphate (TCP) and tristrontium phosphate (TSP) were studied. The focus was to determine the sedimentation kinetics such as rate, order and rate constant of TCP and TSP at varying temperatures using the modified initial rate (Isolation) method. It was observed that whereas effect of temperature was not significant, low concentrations (< 0.04M) of the metal and phosphate ions markedly influenced the initial sedimentation rates of TCP and TSP precipitates.TCP sedimentation order ranged between 0.63 and 1.23 at constant phosphate ions concentration and between 1.52 and 2.10 at constant calcium ions concentration. TSP sedimentation order also ranged between 0.58 and 1.31 at constant phosphate ions concentration and between 1.55 and 1.81 at constant strontium ions concentration. Furthermore, ranges of sedimentation rate constants were obtained. At constant phosphate ions concentration, 1.80 × 10 -4 -1.57 × 10 -3 and 1.51 × 10 -4 -2.45 × 10 -3 were obtained for TCP and TSP, respectively. At constant metal ions concentration 1.71 × 10 -5 -9.54 × 10 -5 and 5.70 × 10 -5 -1.12 × 10 -4 were respectively obtained for TCP and TSP. Data may be employed as additional design information for modeling physiochemical phosphate removal in water treatment technology.

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Rheology in Pharmaceutical Formulations-A Perspective

Cited by 37 publications

References 13 publications

Effect of sodium carboxymethylcellulose biopolymer on sedimentation properties of trimagnesium, tricalcium and tristrontium phosphates precipitates

Effect of sodium carboxymethylcellulose biopolymer on sedimentation properties of trimagnesium, tricalcium and tristrontium phosphates precipitates

Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase

Influence of temperature and ion concentration on sedimentation characteristics of Tricalcium phosphate (TCP) and Tristrontium phosphate (TSP) Precipitates

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