Rheology and nanostructure of hydrophobically modified alginate (HMA) gels and solutions

Choudhary, Soumitra; Bhatia, Surita R.

doi:10.1016/j.carbpol.2011.08.025

Cited by 40 publications

(28 citation statements)

References 39 publications

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“…[31][32][33] In contrast, chitin powder profile shows an extended power-law regime with α near to 3.5, indicative of surface fractals (Inset Fig. 4a).…”

Section: Saxs Analysismentioning

confidence: 99%

Chitin based hybrid composites reinforced with graphene derivatives: a nanoscale study

et al. 2015

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In this work, we present two novel nanostructured hybrid materials based on a chitin matrix loaded with increasing amounts of graphene oxide and reduced graphene oxide nanosheets (nGO and rGO respectively). Both kind materials (Chi:nGO and Chi:rGO) were studied using different spectroscopic and rheological techniques with the aim of understanding the interaction mechanism between chitin and nGO/rGO and explaining how the type of filler and its proportion affects its reinforcement. The production of these hybrids represents not only the obtention of low-cost materials with mechanical resistance but also a good opportunity for developing materials with several applications according to their composition. The nGO and rGO were characterised through FT-IR and ESR for the determination of oxidation degree of each nanofiller. Then, the hybrids were spectroscopically analysed with FT-IR, ESR and SAXS which demonstrated that the components do not interact through covalent bondings and the nanosheets are well-dispersed among the chitin matrix. Finally, a rheological behavior assay results was performed and its results were analysed in terms of G' and η*. In short, all the results allowed us to conclude that nGO acts as a more efficient reinforcer than rGO due to the higher amount of hydrogen bondings established with chitin.

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“…[31][32][33] In contrast, chitin powder profile shows an extended power-law regime with α near to 3.5, indicative of surface fractals (Inset Fig. 4a).…”

Section: Saxs Analysismentioning

confidence: 99%

Chitin based hybrid composites reinforced with graphene derivatives: a nanoscale study

et al. 2015

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“…found that hydrophobic modification of alginate hydrogels resulted in different SAXS scattering profiles. These profiles were evaluated using fractal analysis and they found that there were different regions of more loosely or tightly packed networks which they attribute to regions of hydrophilic or hydrophobic interactions (93). …”

Section: Small Angle Scattering In Biomaterials Researchmentioning

confidence: 99%

Using small-angle scattering techniques to understand mechanical properties of biopolymer-based biomaterials

Hyland

Taraban

2013

Soft Matter

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The design and engineering of innovative biopolymer-based biomaterials for a variety of biomedical applications should be based on the understanding of the relationship between their nanoscale structure and mechanical properties. Down the road, such understanding could be fundamental to tune the properties of engineered tissues, extracellular matrices for cell delivery and proliferation/differentiation, etc. In this tutorial review, we attempt to show in what way biomaterial structural data can help to understand the bulk material properties. We begin with some background on common types of biopolymers used in biomaterials research, discuss some typical mechanical testing techniques and then review how others in the field of biomaterials have utilized small-angle scattering for material characterization. Detailed examples are then used to show the full range of possible characterization techniques available for biopolymer-based biomaterials. Future developments in the area of material characterization by small-angle scattering will undoubtedly facilitate the use of structural data to control the kinetics of assembly and final properties of prospective biomaterials.

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“…For example, creating interpenetrating networks (IPNs) or semi‐IPNs of alginate and other polymers has been explored as a means to better control rheology and gelation behavior of alginate‐based biomaterials . The grafting of hydrophobic chains onto alginate polymers to create hydrophobically‐modified alginate (HMA) has been studied by our group and others as a way to enhance mechanical robustness and improve solubility of hydrophobic drugs within alginate matrices. Studies on composite hydrogels of alginate, surfactants (e.g., Pluronic® F68 (F68)), and perfluorocarbons (PFCs) to determine the applicability of these formulations for cell encapsulation and protein or drug delivery have been reported .…”

Section: Introductionmentioning

confidence: 99%

Terminal sterilization of alginate hydrogels: Efficacy and impact on mechanical properties

et al. 2013

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Terminal, or postprocessing, sterilization of composite biomaterials is crucial for their use in wound healing and tissue-engineered devices. Recent research has focused on optimizing traditional biomaterial formulations to create better products for commercial and academic use which incorporate hydrophobic compounds or secondary gel networks. To use a hydrogel in a clinical setting, terminal sterilization is necessary to ensure patient safety. Lyophilization, gamma-irradiation, and ethylene oxide treatment all have negative consequences when applied to alginate scaffolds for clinical use. Here, we aim to find alternative terminal sterilization methods for alginate and alginate-based composite hydrogels which maintain the structure of composite alginate networks for use in biomedical applications. A thorough investigation of the effect of common sterilization methods on swollen alginate-based hydrogels has not been reported and therefore, this work examines autoclaving, ethanol washing, and ultraviolet light as sterilization techniques for alginate and alginate/Pluronic® F68 composite hydrogels. Preservation of structural integrity is evaluated using shear rheology and analysis of water retention, and efficacy of sterilization is determined via bacterial persistence within the hydrogel. Results indicate that ethanol sterilization is the best method of those investigated because ethanol washing results in minimal effects on mechanical properties and water retention and eliminates bacterial persistence. Furthermore, this study suggests that ethanol treatment is an efficacious method for terminally sterilizing interpenetrating networks or other composite hydrogel systems.

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Rheology and nanostructure of hydrophobically modified alginate (HMA) gels and solutions

Cited by 40 publications

References 39 publications

Chitin based hybrid composites reinforced with graphene derivatives: a nanoscale study

Chitin based hybrid composites reinforced with graphene derivatives: a nanoscale study

Using small-angle scattering techniques to understand mechanical properties of biopolymer-based biomaterials

Terminal sterilization of alginate hydrogels: Efficacy and impact on mechanical properties

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