Rheology and morphology of Pluronic F68 in water

Costanzo, Salvatore; Sarno, Alfonso Di; D'Apuzzo, M.; Avallone, Pietro Renato; Raccone, Ernesto; Bellissimo, Annalisa; Auriemma, Finizia; Grizzuti, Nino; Pasquino, Rossana

doi:10.1063/5.0049722

Cited by 23 publications

(19 citation statements)

References 40 publications

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“…Its T m was found to be approximately 56 • C according to both techniques, while the enthalpy associated to the transition was around 0.04 J/g of solution. The observed T m value for Poloxamer 188 water dispersion was in accordance with the literature: indeed, a single endothermic transition can be recognized, probably related to dehydration of the PEO-rich corona, leading to the formation of micelles or the transformation of micelles into other aggregates [30][31][32]. All hybrid samples showed an endothermic transition in the range 45-55 • C related to the Poloxamer 188 thermal transition, which is affected by the addition of the different non-ionic surfactant according to various weight ratios.…”

Section: Thermal Characterization By Microdscsupporting

confidence: 89%

“…Therefore, the T m decreased after the introduction of the surfactant molecules to Poloxamer 188 solutions in all prepared samples. recognized, probably related to dehydration of the PEO-rich corona, leading to the formation of micelles or the transformation of micelles into other aggregates [30][31][32]. All hybrid samples showed an endothermic transition in the range 45-55 °C related to the Poloxamer 188 thermal transition, which is affected by the addition of the different nonionic surfactant according to various weight ratios.…”

Section: Thermal Characterization By Microdscmentioning

confidence: 98%

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Non-Ionic Surfactant Effects on Innate Pluronic 188 Behavior: Interactions, and Physicochemical and Biocompatibility Studies

Kontogiannis

Selianitis

Perinelli

et al. 2022

IJMS

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The aim of this research was to prepare novel block copolymer-surfactant hybrid nanosystems using the triblock copolymer Pluronic 188, along with surfactants of different hydrophilic to lipophilic balance (HLB ratio—which indicates the degree to which a surfactant is hydrophilic or hydrophobic) and thermotropic behavior. The surfactants used were of non-ionic nature, of which Tween 80® and Brij 58® were more hydrophilic, while Span 40® and Span 60® were more hydrophobic. Each surfactant has unique innate thermal properties and an affinity towards Pluronic 188. The nanosystems were formulated through mixing the pluronic with the surfactants at three different ratios, namely 90:10, 80:20, and 50:50, using the thin-film hydration technique and keeping the pluronic concentration constant. The physicochemical characteristics of the prepared nanosystems were evaluated using various light scattering techniques, while their thermotropic behavior was characterized via microDSC and high-resolution ultrasound spectroscopy. Microenvironmental parameters were attained through the use of fluorescence spectroscopy, while the cytotoxicity of the nanocarriers was studied in vitro. The results indicate that the combination of Pluronic 188 with the above surfactants was able to produce hybrid homogeneous nanoparticle populations of adequately small diameters. The different surfactants had a clear effect on physicochemical parameters such as the size, hydrodynamic diameter, and polydispersity index of the final formulation. The mixing of surfactants with the pluronic clearly changed its thermotropic behavior and thermal transition temperature (Tm) and highlighted the specific interactions that occurred between the different materials, as well as the effect of increasing the surfactant concentration on inherent polymer characteristics and behavior. The formulated nanosystems were found to be mostly of minimal toxicity. The obtained results demonstrate that the thin-film hydration method can be used for the formulation of pluronic-surfactant hybrid nanoparticles, which in turn exhibit favorable characteristics in terms of their possible use in drug delivery applications. This investigation can be used as a road map for the selection of an appropriate nanosystem as a novel vehicle for drug delivery.

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Section: Thermal Characterization By Microdscsupporting

confidence: 89%

Section: Thermal Characterization By Microdscmentioning

confidence: 98%

Non-Ionic Surfactant Effects on Innate Pluronic 188 Behavior: Interactions, and Physicochemical and Biocompatibility Studies

Kontogiannis

Selianitis

Perinelli

et al. 2022

IJMS

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“…Hence, the complex of the photoresist and F-68 would have a hydrophobic photoresist as the core, and the PEO and PPO chains of F-68 as the corona and anchor parts, respectively. According to a previous study, F-68 forms micelles at 40% w/w or more at room temperature. In particular, although F-68 was dissolved as unimers, it possibly formed a core-corona complex with the photoresist in the EC/PC/water mixture.…”

Section: Resultsmentioning

confidence: 90%

Anti-adsorption Mechanism of Photoresist by Pluronic Surfactants: An Insight into Their Adsorbed Structure

et al. 2023

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Photoresist stripping is the final step in the photolithography process that forms fine patterns for electronic devices. Recently, a mixture of ethylene carbonate (EC) and propylene carbonate (PC) has attracted attention as a new stripper based on its eco-friendliness and anti-corrosiveness. However, the EC/PC mixture causes re-adsorption of the photoresist during a process of subsequent water rinsing. In this study, we characterized the adsorption/ desorption of the photoresist and a triblock Pluronic surfactant [poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)] as a blocking agent on an indium tin oxide (ITO) substrate. In addition, we evaluated the dispersion of photoresist particles. The photoresist polymer formed a thin and rigid adsorption layer on an ITO substrate in the EC/PC mixture. When water was injected into the EC/PC mixture and the photoresist solutions, the photoresist polymer aggregated and was then deposited on the substrate. In contrast, the addition of Pluronic surfactant F-68 (PEO 79 PPO 30 PEO 79 ) into the EC/PC mixture remarkably decreased the residual amount of the photoresist on the ITO after water injection. This variation was attributed to the PEO blocks of F-68 extended to the solution phase, whereas the PPO blocks of F-68 functioned as anchors for adsorption onto the photoresist. Therefore, the F-68adsorbed layer prevented interaction between the photoresist particles or the photoresist and the ITO surface, which provides potential for future applications as new stripping agents with high removal performance.

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“…Above 8 °C, Pluronic unimers start to arrange themselves into spherical micellar structures, and as a consequence, η 0 sharply increases with increasing temperature. Costanzo et al 21 clearly describe the increase in viscosity with temperature as mainly due to the increase in the volume fraction of the spherical micelles upon increasing temperature, in turn related to an increase in micelles number, being the micellar radius (and, as such, its volume) practically constant with temperature. Figure 3 illustrates the variation of the steady viscosity, η 0 , with the temperature for all investigated samples.…”

Section: ■ Resultsmentioning

confidence: 99%

Pluronic F68 Micelles as Carriers for an Anti-Inflammatory Drug: A Rheological and Scattering Investigation

Di Spirito,

Grizzuti,

Lutz-Bueno

et al. 2024

Langmuir

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Age-long ambition of medical scientists has always been advancement in healthcare and therapeutic medicine. Biomedical research indeed claims paramount importance in nanomedicine and drug delivery, and the development of biocompatible storage structures for delivering drugs stands at the heart of emerging scientific works. The delivery of drugs into the human body is nevertheless a nontrivial and challenging task, and it is often addressed by using amphiphilic compounds as nanosized delivery vehicles. Pluronics belong to a peculiar class of biocompatible and thermosensitive nonionic amphiphilic copolymers, and their self-assemblies are employed as drug delivery excipients because of their unique properties. We herein report on the encapsulation of diclofenac sodium within Pluronic F68 self-assemblies in water, underpinning the impact of the drug on the rheological and microstructural evolution of pluronic-based systems. The selfassembly and thermoresponsive micellization were studied through isothermal steady rheological experiments at different temperatures on samples containing 45 wt % Pluronic F68 and different amounts of diclofenac sodium. The adoption of scattering techniques, small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS), allowed for the description of the system features at the nanometer length scale, providing information about the characteristic size of each part of the micellar structures as a function of temperature and drug concentration. Diclofenac sodium is not a good fellow for Pluronic F68. The triblock copolymer aids the encapsulation of the drug, highly improving its water solubility, whereas diclofenac sodium somehow hinders Pluronic self-assembly. By using a simple empirical model and no fitting parameters, the steady viscosity can be predicted, although qualitatively, through the volume fraction of the micelles extracted through scattering techniques and compared to the rheological one. A tunable control of the viscous behavior of such biomedical systems may be achieved through the suitable choice of their composition.

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Rheology and morphology of Pluronic F68 in water

Cited by 23 publications

References 40 publications

Non-Ionic Surfactant Effects on Innate Pluronic 188 Behavior: Interactions, and Physicochemical and Biocompatibility Studies

Non-Ionic Surfactant Effects on Innate Pluronic 188 Behavior: Interactions, and Physicochemical and Biocompatibility Studies

Anti-adsorption Mechanism of Photoresist by Pluronic Surfactants: An Insight into Their Adsorbed Structure

Pluronic F68 Micelles as Carriers for an Anti-Inflammatory Drug: A Rheological and Scattering Investigation

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