Rheological study of in-situ crosslinkable hydrogels based on hyaluronanic acid, collagen and sericin

Vulpe, Raluca; Cerf, Didier Le; Dulong, Virginie; Popa, Marcel; Peptu, Cătălina Anişoara; Vereştiuc, Liliana; Picton, Luc

doi:10.1016/j.msec.2016.07.003

Cited by 34 publications

(21 citation statements)

References 36 publications

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“…An analysis of rheokinetic data obtained during the formation of functional polyurethane showed that the viscosity of the system would increase with curing time exponentially [22]. In another research carried out by Vulpe [23], an in-situ rheology study was performed on chemically crosslinked hydrogels made of collagen, hyaluronic acid, and sericin to understand the molecular dynamics of crosslinking mixtures and the kinetics of the crosslinking process. Additionally, the rheokinetic studies of the graft polymerization of acrylamide in a concentrated starch solution were performed by Bao and coworkers to understand how the initiator concentration and reaction temperature would impact the reaction progress [24].…”

Section: Introductionmentioning

confidence: 99%

In-Situ Rheological Studies of Cationic Lignin Polymerization in an Acidic Aqueous System

2020

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The chemistry of lignin polymerization was studied in the past. Insights into the rheological behavior of the lignin polymerization system would provide crucial information required for tailoring lignin polymers with desired properties. The in-situ rheological attributes of lignin polymerization with a cationic monomer, [2-(methacryloyloxy)ethyl] trimethylammonium chloride (METAC), were studied in detail in this work. The influences of process conditions, e.g., temperature, component concentrations, and shear rates, on the viscosity variations of the reaction systems during the polymerization were studied in detail. Temperature, METAC/lignin molar ratio, and shear rate increases led to the enhanced viscosity of the reaction medium and lignin polymer with a higher degree of polymerization. The extended reaction time enhanced the viscosity attributing to the larger molecular weight of the lignin polymer. Additionally, the size of particles in the reaction system dropped as reaction time was extended. The lignin polymer with a larger molecular weight and Rg behaved mainly as a viscose (tan δ > 1 or G″ > G′) material, while the lignin polymer generated with smaller molecular weight and shorter Rg demonstrated strong elastic characteristics with a tan (δ) lower than unity over the frequency range of 0.1−10 rad/s.

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Section: Introductionmentioning

confidence: 99%

In-Situ Rheological Studies of Cationic Lignin Polymerization in an Acidic Aqueous System

2020

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“…In rheological terms, a hydrogel is characterized based on deformation of the network depending upon its viscosity change with variables, such as temperature, time or concentration possessing either Newtonian or non-Newtonian behavior. 149 Cross-linkers, which prevent the dissolution of the linked networks into an aqueous environment, can be incorporated into the mesh of these polymers by a variety of methods to yield cross-linked hydrogels. 150 Cross-linking can be achieved either physically or chemically.…”

Section: Design and Structural Modeling Of Hydrogelsmentioning

confidence: 99%

Hydrogels: soft matters in photomedicine

Khurana

Gierlich

Meindl

et al. 2019

Photochem Photobiol Sci

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“…When applying 70 vol% ethanol-precipitated PVA/SS scaffolds to the full-thickness wounds of rats, the wound size was reduced and showed higher extent of type III collagen formation and epithelialization, compared with the control scaffolds without sericin. Silk sericin was also covalent linked with collagen and hyaluronic acid in the presence of ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide [38,39]. When this scaffold had normal human dermal fibroblasts applied, the in vitro cell culture test indicated that this scaffold has a potential use in skin tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Novel 3D porous semi-IPN hydrogel scaffolds of silk sericin and poly(N-hydroxyethyl acrylamide) for dermal reconstruction

Ross¹,

Yooyod²,

Limpeanchob³

et al. 2017

Express Polym. Lett.

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In this work, a novel semi-interpenetrating polymer network (semi-IPN) hydrogel scaffold based on silk sericin (SS) and poly(N-hydroxyethyl acrylamide) (PHEA) was successfully fabricated via conventional free-radical polymerization. The porous structure of the scaffolds was introduced using a lyophilization technique and the effect of cross-linker (XL) on morphology, gelation time and physical properties of hydrogel scaffold was first studied. The results show that using low cross-linker content (0.125, 0.25 and 0.5 wt% XL) produced flexible scaffolds and appropriate gelation times for fabricating the scaffold. Therefore, the polymerization system with a constant percentage of XL at 0.5 wt% was chosen to study further the effect of SS on the physical properties and cell culture of the scaffolds. It was observed that the hydrogel scaffold of PHEA without SS (PHEA/SS-0) had no cell proliferation, whereas hydrogel scaffolds with SS enhanced cell viability when compared to the positive control. The sample of PHEA/SS at 1.25 wt% of SS and 0.5 wt% of cross-linker was the most suitable for HFF-1 cells to migrate and cell proliferation due to possessing a connective porous structure, along with silk sericin. The results proved that this novel porous semi-IPN hydrogel has the potential to be used as dermal reconstruction scaffold.

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Rheological study of in-situ crosslinkable hydrogels based on hyaluronanic acid, collagen and sericin

Cited by 34 publications

References 36 publications

In-Situ Rheological Studies of Cationic Lignin Polymerization in an Acidic Aqueous System

In-Situ Rheological Studies of Cationic Lignin Polymerization in an Acidic Aqueous System

Hydrogels: soft matters in photomedicine

Novel 3D porous semi-IPN hydrogel scaffolds of silk sericin and poly(N-hydroxyethyl acrylamide) for dermal reconstruction

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