Rheological studies to objectify sensations occurring when cosmetic emulsions are applied to the skin

Brummer, R.; Godersky, S

doi:10.1016/s0927-7757(98)00626-8

Cited by 114 publications

(116 citation statements)

References 2 publications

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“…Poloxamer P-127 gels are pseudoplastic, and if shear -deformed, their viscosity decreases. Indeed, we can observe that as the shear rate increases (0.1 to 1000 S -1 ) gel viscosity decreases, the solutions become more fluid, the flow from the container is facilitated and the skin spreading improved (49). This rheological property of poloxamer gels is well known and was reported by other research groups (23,24,29).…”

Section: Discussionsupporting

confidence: 72%

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

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-Purpose. Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetration enhancer, on the in vitro release of LM from poloxamer-based delivery systems (PBDS). The rheological behavior (shear rate dependent viscosity) and gelation temperature through measurements of optimal sol-gel transition temperatures (T sol-gel ) were also carried out in these systems. Methods. In vitro release studies of LM from PBDS were performed using cellulose acetate as artificial membrane mounted in a diffusion system. The amount of LM released was divided by exposition area (µg/cm 2 ) and these values were plotted as function of the time (h). The flux of the drug across the membrane (J) was calculated from the slope of the linear portion of the plot and expressed as µg/cm 2 /h. The determination of viscosity was carried out at different shear rates (γ) between 0.1-1000 S -1 using a parallel plate rheometer. Oscillatory measurements using a cone-plate geometry rheometer surrounded by a double jacket with temperature varying 4-40°C, was used in order to determine T sol-gel . Results. Increase of both polymer and OA concentrations increases the viscosity of the gels and consequently reduces the in vitro LM release from the PBDS, mainly for gels containing OA at 10.0% (w/w) compared to other concentrations of the penetration enhancer. T sol-gel transition temperature was decreased by increasing viscosity; in some cases the formulation was already a gel at room temperature. Rheological studies showed a pseudoplastic behavior, which facilitates the flow and improves the spreading characteristics of the formulations. Conclusions. Taken together, the results showed that poloxamer gels are good potential delivery systems for LM, leading to a sustained release, and also have appropriate rheological characteristics.

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Section: Discussionsupporting

confidence: 72%

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

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“…But these tests are costly, timeconsuming and subjective. [3] There is currently considerable interest to develop ways to improve the measurement of tactile perception. [4] The aim is to objectify the assessment by measurement of physical parameters that determine the skin feel of products.…”

Section: Introductionmentioning

confidence: 99%

“…[4] The aim is to objectify the assessment by measurement of physical parameters that determine the skin feel of products. [3] Only selected products would then have to be submitted to extensive field tests. Moreover, such measurements would inform the design of attractive, desirable products.…”

Section: Introductionmentioning

confidence: 99%

Particulate lubricants in cosmetic applications

Timm

Myant

Spikes

et al. 2011

Tribology International

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Polymer powders are commonly added to cosmetic formulations to improve product performance and skin feel. This study investigates the effect of particle concentration and size on the lubricating properties of powder suspensions. Results are reported for various particle sizes and concentrations.When the tribological contact was fully immersed the addition of particles had no effect.However different behaviour was observed when the contact was only partially-lubricated. In this case, a three stage friction coefficient curve was observed. By varying the particle size and concentration it was shown that the duration and magnitude of each stage can be controlled.

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“…Owing to the fact that rheology can give a better picture of the behaviour of a material, it is therefore widely used as a tool to test the texture and flow behaviour of industrial products especially in the processing industries such as food (Lorenzo et al 2008), cosmetics (Bummer & Godersky 1999), pharmaceuticals (Zumalacarregui et al 2004), polymer (Karg et al 1985), coating (Kikic et al 1979), and oil processing (Martin et al 2006). The rheological results also enable scientists to estimate the product's quality such as elasticity, viscosity, deformability, storage, shelf life including intermolecular interactions due to ultra-sensitivity at microstructure of materials.…”

Section: Fabrication Rheology and Antioxidant Activity Of Palm Estermentioning

confidence: 99%

Fabrication, Rheology and Antioxidant Activity of Palm Esters-based Emulsions Loaded with Tocotrienol

Mahiran

Zahariyah³

2014

AJSTD

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Palm oil esters are wax esters derived from palm oil and oleyl alcohol. Palm oil esters have many applications due to their luxurious moisturizing properties, non-greasy and blend easily with fragrances and colours when applied on skin surface. The aim of this research was to fabricate palm esters-based emulsions cream for topical delivery, characterise the rheological properties and in vitro antioxidant activity of the palm esters-based emulsions system.Emulsions containing palm oil esters loaded with tocotrienol were obtained in two stages, with propagation of rotor-stator at 6000 r.p.m. for 5 min and further emulsified using an ultrasound at various acoustic amplitudes for another 5 min. A stress/rate controlled Kinexus Rheometer with a temperature controller was used to measure the rheological properties of the emulsion. Rheology measurements were performed at 25.0°C ± 0.1°C with 4°/40 mm cone and plate geometry. The in vitro antioxidant activity was investigated using UV-Vis spectrophotometer.The yield stress of the emulsions increased with increasing acoustic amplitudes. The viscoelasticity of the emulsions were enhanced by the increase in the oil and surfactant concentrations. The emulsions with higher oil phase concentration [30% (w/w)] showed greater elasticity which implied strong dynamic rigidity of the emulsions. The cohesive energy increased significantly with surfactant concentration especially for the emulsions with 30% (w/w) oil phase concentration. The palm oil esters emulsions containing tocotrienol gave higher Trolox equivalent antioxidant capacity values which implied higher antioxidant capability.The tocotrienol in emulsion with 30% (w/w) dispersed phase showed that they were the most stable with longest shelf life and exhibited greater inhibitory effects on the ABTS•+ .

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Rheological studies to objectify sensations occurring when cosmetic emulsions are applied to the skin

Cited by 114 publications

References 2 publications

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

Particulate lubricants in cosmetic applications

Fabrication, Rheology and Antioxidant Activity of Palm Esters-based Emulsions Loaded with Tocotrienol

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