Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac

Chawla, Viney; Saraf, Shubhini A.

doi:10.1016/j.colsurfb.2011.12.006

Cited by 60 publications

(29 citation statements)

References 15 publications

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“…Incorporation of niosomes in semisolid gel forms a colloidal network that aligns itself in the direction of applied shear showing pseudoplastic behavior (a shear thinning system showing decrease in viscosity on application of shear stress) which facilitates its topical application (19)(20)(21). Lor-Nio gel had better spreadability over plain Carbopol gel.…”

Section: Discussionmentioning

confidence: 99%

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Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

2013

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Abstract. Lornoxicam is a potent oxicam class of non steroidal anti-inflammatory agent, prescribed for mild to moderate pain and inflammation. Niosomal gel of lornoxicam was developed for topical application. Lornoxicam niosomes (Lor-Nio) were fabricated by thin film hydration technique. Bilayer composition of niosomal vesicles was optimized. Lor-Nio dispersion was characterized by DSC, XRD, and FT-IR. Morphological evaluation was performed by scanning electron microscopy (SEM). Lor-Nio dispersion was incorporated into a gel using 2% w/w Carbopol 980 NF. Rheological and texture properties of LorNio gel formulation showed suitability of the gel for topical application. The developed formulation was evaluated for in vitro skin permeation and skin deposition studies, occlusivity test and skin irritation studies. Pharmacodynamic activity of the Lor-Nio gel was performed by carragenan-induced rat paw model. Optimized Lor-Nio comprised of Span 60 and cholesterol in a molar ratio of 3:1 with 30 μM dicetyl palmitate as a stabilizer. It had particle size of 1.125±0.212 μm (d 90 ), with entrapment efficiency of 52.38± 2.1%. DSC, XRD, and IR studies showed inclusion of Lor into niosomal vesicles. SEM studies showed spherical closed vesicular structure with particles in nanometer range. The in vitro skin permeation studies showed significant improvement in skin permeation and skin deposition for Lor-Nio gel (31.41±2.24 μg/ cm 2 , 30.079±1.2 μg/cm 2 ) over plain lornoxicam gel (7.37±1.27 μg/cm 2 , 6.6±2.52 μg/cm 2 ). The Lor-Nio gel formulation showed enhanced anti-inflammatory activity by exhibiting mean edema inhibition (87.69± 1.43%) which was significantly more than the plain lornoxicam gel (53.84±2.21%).

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Section: Discussionmentioning

confidence: 99%

“…Dynamic shear strain ranging from 0.1 to 100 S −1 was applied to the sample and the shear stress and the viscosity expended by the sample by imposed shear strain was measured. The measurements were performed at isothermal condition of 37°C (19)(20)(21).…”

Section: Characterization Of Optimized Lor-nio Dispersionmentioning

confidence: 99%

Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

2013

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“…The sample was subjected to dynamic shear strain from 0.1 to 100 S −1 and the shear stress and the viscosity expended by the sample by imposed shear strain was measured. All the measurements were performed at isothermal condition of 37°C (23)(24)(25).…”

Section: Rheological Evaluation Of Trb Nlhmentioning

confidence: 99%

Nanolipidgel for Enhanced Skin Deposition and Improved Antifungal Activity

Wavikar

Vavia

2012

AAPS PharmSciTech

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Abstract. The purpose of the research was to prepare and evaluate a topical nanolipidgel (NLH) of terbinafine hydrochloride (TRB), an antimycotic agent, for enhanced skin deposition and improved antifungal activity. Topical solid lipid nanoparticles (SLN) based nanolipidgel was formulated and evaluated. TRB-loaded SLNs were formulated by high-pressure homogenization technique. The stable TRB SLN dispersion was incorporated into a gel using 1% Carbopol 980 NF. Rheological evaluation and texture analysis of the TRB NLH was carried out. Skin permeation, skin deposition, antifungal activity, and occlusivity studies of the nanolipidgel formulation were carried out. The safety of the TRB NLH gel was evaluated using acute skin irritation test on New Zealand White rabbits. The SLN dispersion containing 10% of glyceryl monostearate, 3% of Tween 80, and 1% Plurol Oleique was the most stable. The optimized TRB SLN had a particle size and zeta potential value of 148.6 ± 0.305 nm and −20.4 ±1.2 mV, respectively. TRB NLH had excellent rheological and texture properties to facilitate its topical application. TRB NLH showed increased skin deposition of the drug over plain (3-fold) and marketed TRB formulation (2-fold). TRB NLH had significantly enhanced antifungal activity against Candida albicans. TRB NLH showed efficient occlusivity and was non-irritant to the rabbit skin with no signs of erythema or edema. Solid lipid nanoparticles-based topical nanolipidgel of terbinafine can be an efficient, industrially scalable, and cost-effective alternative to the existing conventional formulations.KEY WORDS: in vitro antifungal activity; rheological analysis of gel; solid lipid nanoparticles; terbinafine; texture analysis of gel.

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“…It allows rapid termination of drug effects when necessary (El-Kattan et al, 2000;Naik et al, 2000). Carbopols are synthetic polymers of acrylic acid cross-linked with various chemicals such as divinyl-glycol, allyl-sucrose and polyalkenyl polyether (Chawla & Saraf, 2012). It is soluble in polar solvents and upon salvation, they swells, and in presence of a neutralizing agent forming a microgel system (GarciaGonzalez et al, 1994;Weber et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

et al. 2014

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In order to develop transdermal drug delivery system that facilitates the skin permeation of Pioglitazone (PZ) encapsulated in carbopol-based transgel system (proniosomes/niosome). The developed formulations were optimized using quality by design (QbD) approach and particle size, percentage entrapment and transdermal flux were determined. It was found to be more efficient delivery carriers with high encapsulation and enhanced flux value demonstrated that the permeation of PZ through skin was significantly increased with developed formulation. The transdermal enhancement from proniosome was 3.16 times higher than that of PZ from control formulation (ethanol buffer formulation, 3:7), which was further confirmed by confocal laser scanning microscopy. In vivo pharmacokinetic study of carbopol transgel showed a significant increase in bioavailability (2.26 times) compared with tablet formulation. It also showed better antidiabetic activity in comparison to marketed tablet, so our results suggest that carbopol-based transgel are an efficient carrier for delivery of pioglitazone through skin.

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Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac

Cited by 60 publications

References 15 publications

Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

Niosomal Gel of Lornoxicam for Topical Delivery: In vitro Assessment and Pharmacodynamic Activity

Nanolipidgel for Enhanced Skin Deposition and Improved Antifungal Activity

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

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