Rheological studies on mixed phospholipid sols and their interaction with penicillins I. Continuous shear viscometry

Padfield, John M.; Kellaway, I.W.

doi:10.1016/0009-3084(73)90060-1

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…The decrease observed for penicillin systems could be due to several effects: the antibiotic could bind to the phospholipid and thus diffuse at a slower rate, with a reduction in the amount of antibiotic available for self-diffusion; because of the presence of large phospholipid aggregates or micelles (less than 0.1 pm diameter) the diffusion path which the antibiotic has to follow will be longer and more tortuous; or the viscosity of the antibiotic-phospholipid solution retards the diffusion of the antibiotic. The latter is unlikely because a 2% dispersion of phosphatidylcholine in water at 25" has a relative viscosity of 1.2202 (Padfield & Kellaway, 1973b). Dispersions used in these studies had much lower concentrations, and hence viscosities.…”

Section: R E S U L T S a N D Discussionmentioning

confidence: 89%

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The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

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The self-diffusion coefficients of penicillin G and ampicillin have been determined at 25" in water and in the presence of a swamping concentration of electrolyte. The antibiotics diffused through phospholipid dispersions at a reduced rate due to interaction with the lipid aggregates. Ampicillin diffused through the phosphatidylcholine and phosphatidylethanolamine dispersions more rapidly than penicillin G, whereas the latter diffused more rapidly through the lysophosphatidylcholine dispersions. Estimates of binding have been made from these data and compared with those obtained from equilibrium dialysis studies. Surface tension measurements indicated that the antibiotics exhibited minimal surface activity. These results have been correlated with data obtained in other studies and a possible explanation has been advanced for the reported differences in in vivo activity of penicillin G and ampicillin.

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Section: R E S U L T S a N D Discussionmentioning

confidence: 89%

“…The latter is unlikely because a 2% dispersion of phosphatidylcholine in water at 25" has a relative viscosity of 1.2202 (Padfield & Kellaway, 1973b). Dispersions used in these studies had much lower concentrations, and hence viscosities.…”

Section: John M Padfield and I W Kellaway R E S U L T S A N D D Imentioning

confidence: 89%

The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

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“…However, if they do bind to the platelet membrane, their binding affinity must be very low because washing or gel filtration of platelets reverses their inhibitory effects. Penicillin is also known to interact hydrophobically with artificial phospholipid bilayers (38). Thus, it could associate with platelet membrane lipids.…”

Section: Resultsmentioning

confidence: 99%

Carbenicillin and Penicillin G Inhibit Platelet Function In Vitro by Impairing the Interaction of Agonists with the Platelet Surface

Shattil¹,

Bennett²,

McDonough³

et al. 1980

J. Clin. Invest.

108

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“…There might be several hypothesis for this fact: first, it may be suggested that, although penicillin is not very much de graded in vivo, some derivatives might have a stronger action than the antibiotic itself, requiring lower doses; second, under continuous perfu sions, patients' platelets are suffusing in penicillin for long periods of time, and it may be assumed that this long contact-time permits some interferences between certain particular structures of platelets and the antibiotic. The possible interferences with some membrane phospholi pids might also be considered [10].…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> and <i>in vivo</i> Influence of Penicillin G on Platelet Aggregation

Houbouyan¹,

Stoltz²,

Goguel³

1975

Acta Haematol

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The influence of penicillin G on the in vitro and in vivo ADP-induced platelet aggregation and on the platelet electrophoretic mobility has been studied. The in vitro investigations in presence of penicillin concentrations varying between 1,000 and 10,000 IU/ml of plasma, and doses of adenosine diphosphate (ADP) between 0.3 and 25 μM/ml, have shown that the photometric aggregation, as well as the screen filtration pressure are both decreased, according to the doses of antibiotic and ADP. The electrophoretic mobility is also impaired. The in vivo study of 8 patients submitted to massive penicillin therapy for bacterial endocarditis seems to be in agreement with the in vitro results, and has shown a prolonged bleeding time, an hypoadhesiveness, an impaired photometric aggregation with an early disaggregation and a decrease of the screen filtration pressure and platelet electrophoretic mobility.

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Rheological studies on mixed phospholipid sols and their interaction with penicillins I. Continuous shear viscometry

Cited by 13 publications

References 24 publications

The diffusion of penicillin G and ampicillin through phospholipid sols

The diffusion of penicillin G and ampicillin through phospholipid sols

Carbenicillin and Penicillin G Inhibit Platelet Function In Vitro by Impairing the Interaction of Agonists with the Platelet Surface

<i>In vitro</i> and <i>in vivo</i> Influence of Penicillin G on Platelet Aggregation

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