Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity

Jones, David S.; Bruschi, Marcos Luciano; Freitas, Osvaldo de; Gremião, Maria Palmira Daflon; Lara, Elza Helena Guimarães; Andrews, Gavin

doi:10.1016/j.ijpharm.2009.01.006

Cited by 194 publications

(179 citation statements)

References 35 publications

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“…And local drug delivery through mill-rod implants has shown efficacious antitumor response (Qian, 2003). Considerable research has been conducted on drug release in vitro Alexis, 2005;Jones et al, 2009;Kasperczyk et al, 2009) and drug transport in vivo (Rabin et al, 2008;Santoveña et al, 2010). Biodegradable polymers are widely researched and used in implantable drug delivery system (Xiaosong and Roland, 2006;Martin and Roland, 2008;Kumari et al, 2010).…”

Section: Original Articlementioning

confidence: 99%

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

et al. 2012

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Section: Original Articlementioning

confidence: 99%

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

et al. 2012

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“…31 Jones et al investigated the bioadhesion of different gels for xerostomia treatment, and they also observed that the gel composed of C974 enhanced the residence time of the product. 32 Thereby, the objectives of this study were to develop and characterize a nanostructured, bioadhesive LCS composed of C974 dispersion as the aqueous phase, oleic acid (OA) as the oily phase, and polyoxypropylene-(5)-polyoxyethylene-(20)-cetyl alcohol as the surfactant to incorporate the p1025 peptide and to evaluate its in vitro cytotoxicity and effect against the formation of S. mutans biofilm.…”

Section: Calixto Et Almentioning

confidence: 99%

Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of <em>Streptococcus mutans </em>biofilms

Calixto¹,

Duque²,

Aida³

et al. 2017

IJN

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Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, analogous to the fragments 1025–1044 of S. mutans cellular adhesin, responsible for the adhesion and formation of dental biofilm. However, peptides have physicochemical characteristics that may affect their biological action, limiting their clinical performance. Therefore, drug-delivery systems, such as a bioadhesive liquid-crystalline system (LCS), may be attractive strategies for peptide delivery. Potentiation of the action of LCS can be achieved with the use of bioadhesive polymers to prolong their residence on the teeth. In line with this, three formulations – polyoxypropylene-(5)-polyoxyethylene-(20)-cetyl alcohol, oleic acid, and Carbopol C974P in different combinations (F1C, F2C, and F3C) were developed to observe the influence of water in the LCS, with the aim of achieving in situ gelling in the oral environment. These formulations were assessed by polarized light microscopy, small-angle X-ray scattering, rheological analysis, and in vitro bioadhesion analysis. Then, p1025 and a control (chlorhexidine) were incorporated into the aqueous phase of the formulation (F + p1025 and F + chlorhexidine), to determine their antibiofilm effect and toxicity on epithelial cells. Polarized light microscopy and small-angle X-ray scattering showed that F1C and F2C were LCS, whereas F3C was a microemulsion. F1C and F2C showed pseudoplastic behavior and F3C Newtonian behavior. F1C showed the highest elastic and bioadhesive characteristics compared to other formulations. Antibiofilm effects were observed for F + p1025 when applied in the surface-bound salivary phase. The p1025-loaded nanostructured LCS presented limited cytotoxicity and effectively reduced S. mutans biofilm formation, and could be a promising p1025-delivery strategy to prevent the formation of S. mutans dental biofilm.

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“…Valores do módulo de armazenamento (G') em função da temperatura das misturas de Poloxamer 407 (P407) e Carbopol  934P (C934). Fonte: Jones et al [34] . Carvalho, F. C. et al…”

Section: Sistemas Bio(muco)adesivos Para Administração Cutânea De Fárunclassified

Plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos propriedades, metodologias e aplicações

Carvalho¹,

Chorilli²,

Gremião³

2014

Polímeros

Self Cite

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Resumo: Nos últimos tempos, grande destaque tem sido dado no estudo de sistemas bio(muco)adesivos de liberação de fármacos, os quais podem promover um direcionamento e uma retenção mais específica do fármaco incorporado no sistema de liberação, empregando as mais variadas membranas de absorção do organismo. Esta plataforma tecnológica combinada com a nanotecnologia oferece possibilidades como a proteção e o controle da liberação; portanto, são excelentes estratégias para aumentar a biodisponibilidade de fármacos. O objetivo deste trabalho foi estudar as plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos, enfatizando suas propriedades, metodologias para mensuração e possíveis aplicações para diferentes vias de administração. Palavras-chave: Bio(muco)adesão, bioadesão, sistemas de liberação de fármacos, nanotecnologia, Mecanismos de bio(muco)adesão, medidas de bio(mucoadesão). Nanotechnology-based Polymeric Bio(muco)Adhesive Platforms for Controlling Drug Delivery -properties, Methodologies and ApplicationsAbstract: Studies using bio(muco)adhesive drug delivery systems have recently gained great interest, which can promote drug targeting and more specific contact of the drug delivery system with the various absorptive membranes of the body. This technological platform associated with nanotechnology offers potential for controlling drug delivery; therefore, they are excellent strategies to increase the bioavailability of drugs. The objective of this work was to study nanotechnology-based polymeric bio(muco)adhesive platforms for controlling drug delivery, highlighting their properties, how the bio(muco)adhesion can be measured and their potential applications for different routes of administration.

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Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity

Cited by 194 publications

References 35 publications

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of <em>Streptococcus mutans </em>biofilms

Plataformas bio(muco)adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos propriedades, metodologias e aplicações

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