Rheological characterization of the nucleus pulposus and dense collagen scaffolds intended for functional replacement

Bron, J.; Koenderink, Gijsje H.; Everts, Vincent; Smit, Theo H.

doi:10.1002/jor.20789

Cited by 40 publications

(54 citation statements)

References 30 publications

(38 reference statements)

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“…Bertolo et al, 2012;Cheng et al, 2010;Cheng et al, 2013;Dai et al, 2011;Iwasaki et al, 2004;Li et al, 2005b;Mao et al, 2004;Di Martino et al, 2005;Patel et al, 2010;Pusateri et al, 2003;Richardson et al, 2008;Roughley et al, 2006;Shao and Hunter, 2007;Sun et al, 2014;Zhang et al, 2014 Alginate Brown seaweed Delayed drug delivery systems Cells cultured in 3D constructs, tested in vivo in murine model. Bron et al, 2011;Chou et al, 2009;Chou and Nicoll, 2009;Guo et al, 1989;Larsen and Haug, 1971;Leone et al, 2008;Li et al, 2008;Lee and Mooney, 2012;…”

Section: Natural Hydrogels Chitosanmentioning

confidence: 99%

“…Alginate Alginate (alginic acid) is a natural biopolymer derived from brown seaweed, generally composed of beta(1-4)-linked D-mannuronic acid (M) and alpha(1-4) linked L-guluronic acid (G) moieties (Bron et al, 2011;Larsen and Haug, 1971). Alginate-based gels can be cross-linked through ionic, covalent and thermal processes.…”

Section: Highlightsmentioning

confidence: 99%

“…In vivo, alginate induces negligible immunological reactions (Leone et al, 2008;Li et al, 2008;Nunamaker et al, 2007). Alginate hydrogel stiffness can be regulated by changing its alginate weight/volume (w/v) percentage (Bron et al, 2011). 2 % (w/v) alginate scaffolds resemble the native NP in terms of stiffness (Bron et al, 2011).…”

Section: Highlightsmentioning

confidence: 99%

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Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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Section: Natural Hydrogels Chitosanmentioning

confidence: 99%

Section: Highlightsmentioning

confidence: 99%

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Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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“…The three main components of IVD aimed at tissue regeneration are: 1) AF (Sato et al, 2003;Chang et al, 2007;Helen and Gough, 2007;Nerurkar et al, 2007;Shao and Hunter, 2007;Wan et al, 2007;Nerurkar et al, 2008;Wang et al, 2008;Nerurkar et al, 2009); 2) NP (Baer et al, 2001;Sakai et al, 2003;Seguin et al, 2004;Bertram et al, 2005;Wilke et al, 2006;Roughley et al, 2006;Cloyd et al, 2007;Chou et al, 2008;Halloran et al, 2008;Richardson et al, 2008;Vernengo et al, 2008;Bron et al, 2009;Chou et al, 2009;Sawamura et al, 2009;Calderon et al, 2010;Silva-Correia et al, 2010a;Silva-Correia et al, 2010b;Reza and Nicoll, 2010;); and 3) both NP and AF by means of using biphasic scaffolds (Mizuno et al, 2004;Hamilton et al, 2005;Mizuno et al, 2006;Nerurkar et al, 2008;Nesti et al, 2008). It has been proposed that for producing a tissue resembling natural IVD, total IVD replacement could be required.…”

Section: Polymeric-based Designsmentioning

confidence: 99%

“…Several strategies aimed at regenerating AF use different types of material, processing techniques, cells source, and phenotypes. Besides, it should be mentioned that the mechanical properties of such implants should resemble those of the native AF (Setton et al, 2007;Bron et al, 2009). This explains in part why strategies for AF regeneration are mainly focused on synthetic materials and their processing onto porous scaffolds and electrospun nets (Sato et al, 2003;Wan et al, 2007;Helen and Gough, 2007;Nerurkar et al, 2007;Nerurkar et al, 2008aNerurkar et al, , 2008bNerurkar et al, 2009;Chang et al, 2007;Wan et al, 2008).…”

Section: Polymeric-based Designsmentioning

confidence: 99%

Intervertebral Disc Regeneration

Libera¹,

Hoell

Holzhausen³

et al.

Fundamentals of Tissue Engineering and Regenerative Medicine

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Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterials-based therapies are the most interesting solutions to date, whereby tissue engineering and regenerative medicine (TE&RM) strategies are included. By using such strategies, i.e., combining biomaterials, cells, and biomolecules, the ultimate goal of reaching a complete integration between native and neo-tissue can be achieved. Hydrogels are promising materials for restoring IVD, mainly nucleus pulposus (NP). This study presents an overview of the use of hydrogels in acellular and cellular strategies for intervertebral disc regeneration. To better understand IVD and its functioning, this study will focus on several aspects: anatomy, pathophysiology, cellular and biomolecular performance, intrinsic healing processes, and current therapies. In addition, the application of hydrogels as NP substitutes will be addressed due to their similarities to NP mechanical properties and extracellular matrix. These hydrogels can be used in cellular strategies when combined with cells from different sources, or in acellular strategies by performing the functionalization of the hydrogels with biomolecules. In addition, a brief summary of therapies based on simple injection for primary biological repair will be examined. Finally, special emphasis will focus on reviewing original studies reporting on the use of autologous cells and biomolecules such as platelet-rich plasma and their potential clinical applications.

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Nucleus pulposus replacement and regeneration/repair technologies: Present status and future prospects

Lewis

2012

J Biomed Mater Res

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Degenerative disc disease is implicated in the pathogenesis of many painful conditions of the back, chief among which is low back pain. Acute and/or chronic low back pain (A/CLBP) afflicts a large number of people, thus making it a major healthcare issue with concomitant cost ramifications. When conservative treatments for A/CLBP, such as bed rest, anti-inflammatory medications, and physical therapy, prove to be ineffectual, surgical options are recommended. The most popular of these is discectomy followed by fusion. Although there are many reports of good to excellent outcomes with this method, there are concerns, such as long-term adverse biomechanical consequences to adjacent functional spinal unit(s). A surgical option that has been attracting much attention recently is replacement or regeneration/repair of the nucleus pulposus, an approach that holds the prospect of not compromising either mobility or function and causing no adjacent-level injury. There is a sizeable body of literature highlighting this option, comprising in vitro biomechanical studies, finite element analyses, animal-model studies, and limited clinical evaluations. This work is a review of this body of literature and is organized into four parts, with the focus being on replacement technologies, regeneration/repair technologies, and detailed expositions on 14 areas for future study. This review ends with a summary of the salient points made.

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Rheological characterization of the nucleus pulposus and dense collagen scaffolds intended for functional replacement

Cited by 40 publications

References 30 publications

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Intervertebral Disc Regeneration

Nucleus pulposus replacement and regeneration/repair technologies: Present status and future prospects

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