Rheological characterization of polymer/ceramic blends for 3D printing of bone scaffolds

Huang, Boyang; Bártolo, Paulo

doi:10.1016/j.polymertesting.2018.04.033

Cited by 40 publications

(41 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SEM images of the scaffold surface show a slightly smoother surface with inclusion of PANI with less pits compared to the PCL scaffold ( Figure 3). The inclusion of particles effects the material rheology and extrusion flow properties, typically imparting shear thinning behaviour, which can influence the final extruded fibre and surface roughness [71]. Furthermore, the hemispherical and semi-round rod theory of close-packed models predicts that a rougher surface leads to a lower contact angle [72].…”

Section: Wettabilitymentioning

confidence: 99%

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

et al. 2020

View full text Add to dashboard Cite

Electrostimulation and electroactive scaffolds can positively influence and guide cellular behaviour and thus has been garnering interest as a key tissue engineering strategy. The development of conducting polymers such as polyaniline enables the fabrication of conductive polymeric composite scaffolds. In this study, we report on the initial development of a polycaprolactone scaffold incorporating different weight loadings of a polyaniline microparticle filler. The scaffolds are fabricated using screw-assisted extrusion-based 3D printing and are characterised for their morphological, mechanical, conductivity, and preliminary biological properties. The conductivity of the polycaprolactone scaffolds increases with the inclusion of polyaniline. The in vitro cytocompatibility of the scaffolds was assessed using human adipose-derived stem cells to determine cell viability and proliferation up to 21 days. A cytotoxicity threshold was reached at 1% wt. polyaniline loading. Scaffolds with 0.1% wt. polyaniline showed suitable compressive strength (6.45 ± 0.16 MPa) and conductivity (2.46 ± 0.65 × 10−4 S/cm) for bone tissue engineering applications and demonstrated the highest cell viability at day 1 (88%) with cytocompatibility for up to 21 days in cell culture.

show abstract

Section: Wettabilitymentioning

confidence: 99%

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The incorporation of HAp into PCL matrix showed good compatibility and printability. In addition, HAp/PCL blends showed shear-thinning behavior and higher elastic modulus than TCP/PCL blends at low frequencies for the same ceramic content (Huang and Bártolo, 2018). Xia et al prepared HAp/PCL printed scaffold using selective laser sintering method.…”

Section: Hap/synthetic Polymer-based Materialsmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

View full text Add to dashboard Cite

Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

show abstract

“…Since there was no cross‐linker utilized, a change was not expected on each stored (G') and dissipated energy (G") curve under constant temperature. All the G' values were higher than G" values at each frequency . Consequently, a viscoelastic fluid behavior was observed .…”

Section: Discussionmentioning

confidence: 79%

A universal self‐eroding sacrificial bioink that enables bioprinting at room temperature

Aydin

Küçük

Kenar

2020

Polymers for Advanced Techs

View full text Add to dashboard Cite

Natural polymer-based hydrogel bioinks are widely used in bioprinting due to their suitability for recapitulation of in vivo cellular activities. However, preservation of the target geometry in a cell-laden hydrogel is difficult to achieve. The aim of this study was to develop a universal sacrificial bioink that allows high cell viability and a better shape fidelity in the cell-laden construct. A polysaccharide-based universal sacrificial bioink was developed for microextrusion-based bioprinting and was optimized to erode in 48 hours in the cell culture medium without formation of any undesired byproducts. The sacrificial hydrogel was prepared from alginate and agarose via a microwave oven assisted method and bioprinted at room temperature to generate microchannels in the cell-laden hydrogel or to support a tubular structure and its biocompatibility determined by live/dead assay. Bioprinting time was significantly reduced, down to a few minutes for a large-scale tissue model (1 minute 52 seconds for a 2 cm tubular structure), by means of a high bioprinting speed up to 25 mm/s. After 48 hours in the cell culture, the sacrificial bioink completely detached from the cell-laden construct without causing any changes in its printed shape. Cell viability in the cell-laden construct was observed to be more than 95% at the end of 3-day culture. This novel sacrificial bioink enables bioprinting at room temperature without affecting oxygen and nutrient penetration into the cell-laden hydrogel and allows retention of high cell viability and shape fidelity. K E Y W O R D Sbioprinting, printability score, sacrificial hydrogel, shape fidelity, universal bioink

show abstract

Rheological characterization of polymer/ceramic blends for 3D printing of bone scaffolds

Cited by 40 publications

References 30 publications

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

A universal self‐eroding sacrificial bioink that enables bioprinting at room temperature

Contact Info

Product

Resources

About