Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels

Ricci, Esther Lopes; Bentley, Maria Vitória Lopes Badra; Farah, Marcelo; Bretas, Rosário Elida Suman; Marchetti, Juliana Maldonado

doi:10.1016/s0928-0987(02)00166-5

Cited by 112 publications

(91 citation statements)

References 26 publications

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“…The viscosities of F11 and Rozex ® were similar. Through this data, we also determined the pseudoplastic behavior of the formulations observed; the viscosity decreases as the shear rate increases (Pereira et al, 2013;Ricci et al, 2002). It is worth adding that, in general, formulations containing P407 gels offer the advantage of thixotropic behavior.…”

Section: Sol-gel Transition Temperaturementioning

confidence: 99%

“…It is worth adding that, in general, formulations containing P407 gels offer the advantage of thixotropic behavior. This is a desirable characteristic when the intention is to facilitate the administration and spreadability in open wounds in order to avoid friction of the gel, thus reducing the suffering of the patient (Ricci et al, 2002;Pereira et al, 2013). The viscosity values apparent at 20 s -1 for the thermosensitive gels were 4.4 Pa ± 1.2 for the F12 gel, 6.5 Pa ± 1.0 for the F11 gel and 7.2 Pa ± 0.6 for Rozex ® .…”

Section: Sol-gel Transition Temperaturementioning

confidence: 99%

“…• C (normal body temperature) for each formulation (15g per sample), at shear rates (γ) between 2 and 200 s −1 (Ricci et al, 2002;Ricci et al, 2005).…”

Section: Rheological Analysismentioning

confidence: 99%

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Metronidazole thermogel improves retention and decreases permeation through the skin

Melo

Araujo

Silva

et al. 2017

Braz. J. Pharm. Sci.

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Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex ® (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex ® . Following a 21 h permeation study, the highest total amount of MTZ permeated through the rat healthy and disturbed skin was seen with Rozex ® , but similar to all formulations regardless of the skin condition. On the other hand, the amount retained in the epidermis/dermis was larger for thermogel formulations; at least 4 fold that of Rozex ® , when the stratum corneum was present as a barrier. In conclusion, thermogel formulations can be favorable alternatives to Rozex ® for the topical application of MTZ with improved efficacy and reduced side effects.Uniterms: Metronidazole/evaluation. Metronidazole/drug retention. Poloxamer 407. Rosacea/treatment. Dermatopharmacokinetic.

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Section: Sol-gel Transition Temperaturementioning

confidence: 99%

Section: Sol-gel Transition Temperaturementioning

confidence: 99%

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Metronidazole thermogel improves retention and decreases permeation through the skin

Melo

Araujo

Silva

et al. 2017

Braz. J. Pharm. Sci.

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“…Syringeability was evaluated on the basis of the ease with which the formulation under test passed through the needle and injectability was evaluated on the basis of the ease with which the formulation was injected into isolated extensor digitorum (chick muscle). [18] The extensor digitorum muscle from Gallus gallus domesticus was procured fresh from a reputable hatchery and the tissue weighing 4.5 g was excised. About 2 ml of formulation was drawn into a syringe with a 20 gauge needle and injected into the muscle.…”

Section: Measurement Of Viscosity and Gel Strengthmentioning

confidence: 99%

Untitled

Koland¹

2017

AJP

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Introduction: Injectable in situ gelling solutions are novel implantable systems that combine the advantages of a prolonged release subdermal implant and the convenience of administration of an aqueous solution. Objectives: The aim of the present investigation was to formulate and evaluate a thermo-reversible injectable in situ gelling system of rivastigmine tartrate. Methods: Injectable in situ gelling solutions loaded with rivastigmine were formulated using the thermosensitive polymers: Pluronic F127 and Pluronic F68. The thermo-reversible gelling solutions were evaluated for gelation temperature, gel strength, syringeability and injectability, drug content, in vitro drug release studies, and ex vivo studies using extensor digitorum muscle of Gallus gallus domesticus. Results: Gelation temperature and gel strength increased with increasing concentrations of Pluronic F 68. All six formulations showed adequate ease on withdrawal and injection. The viscosity of formulations also increased with increase in the percentage of Pluronic F68 both in sol and gel form. An initial burst effect as a result of the immediate drug release from the sol form of the preparation before conversion to gel was observed from all formulations. Drug release was slower with an increase in the concentration of Pluronic F68. Ex vivo drug permeation studies for over 27 h exhibited slower release patterns from the selected formulations as compared to in vitro release. Conclusion:The developed formulations are capable of prolonging release of rivastigmine with the potential of achieving greater therapeutic success in Alzheimer patients compared to the conventional oral dosage forms.

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“…Once the mechanical characteristics of a material have been determined, it is often necessary to improve them in some manner to make the material suitable for the desired application. It is many ways to controlling the mechanical properties: altering the comonomer composition [9,10] increasing or decreasing the cross-linking density [11,12,13] and changing the conditions under which the polymer is formed [14,15].…”

Section: Introductionmentioning

confidence: 99%

Composition dependent changes in the swelling and mechanical properties of nanocomposite hydrogels

et al. 2009

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Abstract. We are synthetized thermo-and pH-sensitive gels, which are then tested as skin extenders. Our aim is the development of copolymer and composite hydrogels that, when implanted under the human skin, swell osmotically and thereby induce skin growth.During the polimerization reaction we are produced copolymers with varyable composition, which are proceed from two acrylic compounds [N-isopropyl-acrylamide (NIPAAm), and acrylamide (AAm)]. The mechanical strength and the swelling stability of the gels are enhanced by the addition of fillers [Na-montmorillonite (Na-m.) and with alkyl-ammonium ion organophilized Na-montmorillonites [(C n -m.), n = 4, 12, 18]. With this method we are synthetized composite-hydrogels. The filler content of composites varies between 1 and 25 wt%.We observed that in the case of composites synthesized with the addition of fillers, relatively low filler contents (1-5 wt%) resulted in more extensive swelling and stronger gel structure.In the course of the experiments the monomer composition of the gels (0/100-100/0 mol% NIPAAm/AAm) and in the case of composites, the quality (montmorillonite and organophilized montmorillonite) and quantity (1-25 wt%) of fillers are varied. The extent of swelling and the viscoelastic properties can be manipulated through the ratios of these parameters.In the case of certain copolymer and composite gels, values of desorption enthalpy (ΔH m ) corresponding to the actual water contents were also determined by thermoanalytical measurements (DSC). Swelling values determined by gravimetry and enthalpies calculated from DSC measurements were found to be in good correlation. Evaluation and comparison of the rheological and DSC results also allowed conclusions to be drawn concerning the types of interaction operating among the three components of the * Corresponding author. E-mail: i.dekany@chem.u-szeged.husystem, i.e. the polymer skeleton, the filler and water molecules. We found that water molecules within the gel matrix are bound to the 3-D polymer lattice with bonds of different strengths and the strength of these interactions are dependent on both hydrophilicity and charge conditions. In the case of hydrophobic NIPAAm composites a more extensive swelling can be achieved by applying montmorillonite fillers with hydrophobized surfaces, whereas in the case of hydrophilic AAm-based composites the use of hydrophilic montmorillonite fillers ensure more extensive swelling.

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Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels

Cited by 112 publications

References 26 publications

Metronidazole thermogel improves retention and decreases permeation through the skin

Metronidazole thermogel improves retention and decreases permeation through the skin

Untitled

Composition dependent changes in the swelling and mechanical properties of nanocomposite hydrogels

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