Rheological changes in the blood of patients with chronic arterial occlusive disease after the administration of vasoactive drugs

Störmer, B.; Kleinschmidt, K.; Loose, Dirk A.; Kremer, K

doi:10.1185/03007997709115275

Cited by 35 publications

(5 citation statements)

References 3 publications

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“…This lack of demonstrable effect on blood viscosity contrasts with the results of previous studies of the intravenous preparation (Heidrich et al, 1976;Stormer et al, 1977). In these earlier studies oxpentifylline was given by infusion in a relatively large volume of fluid and the reported fall in whole blood viscosity may have been secondary to haemodilution.…”

Section: Discussioncontrasting

confidence: 55%

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Brown

1989

Brit J Clinical Pharma

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The effects of intravenous oxpentifylline on blood viscosity and cerebral blood flow were studied in eight patients with cerebrovascular disease using a double‐blind placebo controlled design. A single dose of 200 mg oxpentifylline in 10 ml saline was given by intravenous injection over 10 min and compared with 10 ml saline alone. Whole blood and plasma viscosity were measured in a Contraves LS 30 coaxial viscometer at shear rates of 0.7 and 94.5 s‐1. Cerebral blood flow was measured by the non‐invasive intravenous xenon133 clearance method. The measurements were made before and then 30 min after the start of the injection of drug or saline alone. Oxpentifylline was found to have no significant effect on blood viscosity or cerebral blood flow.

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Section: Discussioncontrasting

confidence: 55%

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Brown

1989

Brit J Clinical Pharma

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“…However, Hodgson, et al 13 reported no improvement in skin flap survival in pigs after the administration of PTX for 7 days following skin flap elevation. When PTX is used to treat claudication, the beneficial therapeutic effects are not generally observed for 2 to 3 weeks 14 . To date, the use of PTX to enhance random skin flap survival has produced inconsistent results, despite good evidence for the drug's beneficial hemorrheologic properties.…”

Section: Background Informationmentioning

confidence: 99%

Evaluation of Random Skin Flap Survival in a Porcine Model

Pratt

1996

The Laryngoscope

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The pathophysiology of random skin flap necrosis in the pig model was studied the effects of several drugs on skin flap survival were examined. The investigated drugs included acetylsalicylic acid (ASA), pentoxifylline (PTX), prostaglandin E2 (PGE2), and an experimental 21-aminosteroid, U-74389G. Each drug altered different parameters known to be associated with tissue necrosis. Demonstrated mechanisms of skin flap failure included the alteration of erythrocyte flexibility and platelet function and the activation of neutrophils with resultant accumulation of damaging oxygen-free radicals. Random skin flap survival did not improve with ASA but did improve significantly with PTX, PGE2, and U-74389G. The results of this study underscore the importance of neutrophil-mediated necrosis in the pathophysiology of skin flap failure. The data further demonstrate the need to develop drugs aimed at reversing or preventing the tissue damage from oxygen-free radicals in order to enhance the survival of random skin flaps.

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“…[27][28][29][30][31][32] Clinical pharmacology studies have confirmed that this effect also occurs in Using an Anger gamma camera/computer system and 99m technetium pertechnetate, our research group conducted a study in 30 geriatric patients with cerebrovascular insufficiency. 21 The investigation revealed that a single intravenous dose of 200 mg (10 ml) pentoxifylline produced a statistically significant increase in cerebral blood flow compared with that after intravenous administration of 10 ml physiological saline solution and in untreated controls.…”

Section: Introductionmentioning

confidence: 69%

The effect of pentoxifylline (‘Trental’) on cerebral blood flow: A double-blind study

Koppenhagen¹,

Wenig²,

Müller³

1977

Current Medical Research and Opinion

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A double-blind, placebo controlled crossover study was carried out in 20 geriatric patients with cerebrovascular insuficiency to assess the eflect of pentoxifylline on cerebral bloodflow. Using 99m Tc cerebral scintigraphy and a gamma cameralcomputer system, the pattern of bloodflow in 5 brain areas was monitored after a single intravenous infusion of 200 mg pentoxifylline (10 ml) and after I 0 ml saline solution. The results showed that, with the exception of one brain area, there was a statistically significant increase both in regional and hemispheric cerebral bloodflow afterpentoxifylline. It is of particular interest that global hemispheric bloodflow, which gives an indication of total bloodsupply to the brain, showedapproximately the same percentage increase on both sides with pentoxifylline.

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Rheological changes in the blood of patients with chronic arterial occlusive disease after the administration of vasoactive drugs

Cited by 35 publications

References 3 publications

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Evaluation of Random Skin Flap Survival in a Porcine Model

The effect of pentoxifylline (‘Trental’) on cerebral blood flow: A double-blind study

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