Rheological, biocompatibility and osteogenesis assessment of fish collagen scaffold for bone tissue engineering

Elango, Jeevithan; Zhang, Jingyi; Bao, Bin; Palaniyandi, Krishnamoorthy; Wang, Shujun; Wu, Wenhui; Robinson, Jeya Shakila

doi:10.1016/j.ijbiomac.2016.05.067

Cited by 94 publications

(44 citation statements)

References 45 publications

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“…The osteogenic activity of scaffold fabricated by marine collagen has been studied for bone tissue engineering applications. Elango et al [ 126 ] extracted collagen from blue shark cartilage and then prepared three types of scaffolds of its collagen, including collagen, collagen–chitosan, and collagen–hydroxyapatite. The physical–functional properties, mechanical properties, biocompatibility, and osteogenesis of scaffolds were investigated.…”

Section: Marine Collagen Biomaterials Applicationmentioning

confidence: 99%

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

et al. 2020

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The utilization of marine-based collagen is growing fast due to its unique properties in comparison with mammalian-based collagen such as no risk of transmitting diseases, a lack of religious constraints, a cost-effective process, low molecular weight, biocompatibility, and its easy absorption by the human body. This article presents an overview of the recent studies from 2014 to 2020 conducted on collagen extraction from marine-based materials, in particular fish by-products. The fish collagen structure, extraction methods, characterization, and biomedical applications are presented. More specifically, acetic acid and deep eutectic solvent (DES) extraction methods for marine collagen isolation are described and compared. In addition, the effect of the extraction parameters (temperature, acid concentration, extraction time, solid-to-liquid ratio) on the yield of collagen is investigated. Moreover, biomaterials engineering and therapeutic applications of marine collagen have been summarized.

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Section: Marine Collagen Biomaterials Applicationmentioning

confidence: 99%

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

et al. 2020

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“…The abundant presence of type I collagen in fish bone tissues has widely increased the applications of collagen-based scaffolds for bone tissue engineering [53,54,55]. Collagen plays an important role in stimulating the differentiation of bone progenitor cells into osteoblasts through interaction with transmembrane α2β1 integrin receptors, and subsequently eliciting cell growth and mineral production [56,57].…”

Section: Marine Fish-derived Collagenmentioning

confidence: 99%

Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

et al. 2017

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Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals using marine fish-derived proteins and peptides obtained from chemical or enzymatical hydrolysis of fish processing by-products has increased rapidly owing to their activities in antioxidation and tissue regeneration. Marine fish-derived collagen has been utilized for the development of cosmeceutical products due to its abilities in skin repair and tissue regeneration. Marine fish-derived peptides have also been utilized for various cosmeceutical applications due to their antioxidant, antimicrobial, and matrix metalloproteinase inhibitory activities. In addition, marine fish-derived proteins and hydrolysates demonstrated efficient anti-photoaging activity. The present review highlights and presents an overview of the current status of the isolation and applications of marine fish-derived proteins and peptides. This review also demonstrates that marine fish-derived proteins and peptides have high potential for biocompatible and effective cosmeceuticals.

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“…When we choose bone graft scaffolds to treat fractures in human body, the desired physical and chemical characteristic of scaffolds must be considered such as biocompatibility, biodegradability, and nontoxicity (Chen et al, ; Hoornaert, d'Arros, Heymann, & Layrolle, ; Mistry, Mikos, & Jansen, ; Thi Hiep et al, ). Collagen is the most renowned material used in biomaterial research (Behring, Junker, Walboomers, Chessnut, & Jansen, ; Dong‐Soo et al, ; Elango et al, ; Inzana et al, ). Collagen comprises the material of bone, teeth, and connected tissue and can be extracted from porcine, duck's feet and human tissues (Kim et al, ; Song et al, ).…”

Section: Introductionmentioning

confidence: 99%

A BMSCs‐laden quercetin/duck's feet collagen/hydroxyapatite sponge for enhanced bone regeneration

Song

Tian

Kook

et al. 2019

J Biomedical Materials Res

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Treating critical-sized bone defects is an important issue in the field of tissue engineering and bone regeneration. From the various biomaterials for bone regeneration, collagen is an important and widely used biomaterial in biomedical applications, hence, it has numerous attractive properties including biocompatibility, hyper elastic behavior, prominent mechanical properties, support cell adhesion, proliferation, and biodegradability. In the present study, collagen was extracted from duck's feet (DC) as a new collagen source and combined with quercetin (Qtn), a type of flavonoids found in apple and onions and has been reported to affect the bone metabolism, for increasing osteogenic differentiation. Further, improving osteoconductive properties of the scaffold hydroxyapatite (HAp) a biodegradable material was used.We prepared 0, 25, 50, and 100 μM Qtn/DC/HAp sponges using Qtn, DC, and HAp. Their physiochemical characteristics were evaluated using scanning electron microscopy, compressive strength, porosity, and Fourier transform infrared spectroscopy. To assess the effect of Qtn on osteogenic differentiation, we cultured bone marrow mesenchymal stem cells on the sponges and evaluated by alkaline phosphatase, 3-4-2, 5-diphenyl tetrazolium bromide assay, and real-time polymerase chain reaction. Additionally, they were studied implanting in rat, analyzed through Micro-CT and histological staining. From our in vitro and in vivo results, we found that Qtn has an effect on bone regeneration. Among the different experimental groups, 25 μM Qtn/DC/HAp sponge was found to be highly increased in cell proliferation and osteogenic differentiation compared with other groups. Therefore, 25 μM Qtn/DC/HAp sponge can be used as an alternative biomaterial for bone regeneration in critical situations. K E Y W O R D S bone marrow mesenchymal stem cells, bone regeneration, duck's feet collagen, hydroxyapatite, quercetin

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Rheological, biocompatibility and osteogenesis assessment of fish collagen scaffold for bone tissue engineering

Cited by 94 publications

References 45 publications

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering

Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

A BMSCs‐laden quercetin/duck's feet collagen/hydroxyapatite sponge for enhanced bone regeneration

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