Rheological Behavior Patterns in Artificial Tears

Blasco-Martínez, Alejandro; Blasco-Alberto, Javier; Pablo-Júlvez, L.

doi:10.1097/opx.0000000000001885

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Consequently, RDA maintains the structure and viscoelastic properties of the MGS duplex multilayer, which are believed to be crucial for the TFLL's ability to restore and maintain the tear film at the ocular surface in vivo during and between blinks [4,10,31]. The formulation additionally endeavors to enhance the secretory-mucin-rich gel layer of human tears by incorporating polyvinylpyrrolidone, a polymer that is believed to augment the tear film's shear thinning properties [35][36][37][38][39][40]. These properties are crucial for the lubricating action of TF during blinking, as well as for its tensile strength when at interblink [41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Surface Chemistry Study of Normal and Diseased Human Meibum Films Prior to and after Supplementation with Tear Mimetic Eyedrop Formulation

Eftimov,

Yokoi,

Tsuji

et al. 2024

Applied Sciences

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Ophthalmic nanoemulsions that can treat the deficiencies of meibum (MGS) in Meibomian gland disease and restore its functionality in the tear film are greatly sought. The Rohto Dry Aid (RDA) formulation employs TEARSHIELD TECHNOLOGYTM, which uses a multicomponent oil phase of polar and non-polar lipid-like molecules selected to mimic the profiles of healthy meibum. Thus, the interactions of RDA with “diseased” Meibomian (dMGS) films merit deeper analysis, as these interactions might offer important clues for both the development of new ocular formulations and the processes behind the therapeutic action of the nanoemulsions. Pseudobinary dMGS/RDA films were spread at the air–water surface of the Langmuir trough. Surface pressure-area isocycles and stress relaxations were used to access the layer’s response to blink-like cycling and dilatational viscoelasticity, respectively, while film morphology was recorded via Brewster angle microscopy. It was found that RDA is able to reverse the brittleness and to restore the stability of “diseased” MGS films and thus to revert the layer’s properties to the functionality of healthy Meibomian lipids. Therefore, in order to effectively treat dry eyes with MGS-oriented therapy, ophthalmic nanoemulsions warrant more research.

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Section: Discussionmentioning

confidence: 99%

Surface Chemistry Study of Normal and Diseased Human Meibum Films Prior to and after Supplementation with Tear Mimetic Eyedrop Formulation

Eftimov,

Yokoi,

Tsuji

et al. 2024

Applied Sciences

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“…where S stands for the shear stress, and D stands for the shear rate (s −1 ) (Pa). N is the Farrow constant, and η is the viscosity (Pa•s) [31].…”

Section: Morphological Study Using Transmission Electron Microscope (...mentioning

confidence: 99%

Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of Experiment and PBPK Physiological Modeling

El Hoffy,

Yacoub,

Ghoneim

et al. 2023

Pharmaceutics

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Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics of the obtained systems. The selection of an appropriate solvent with satisfactory rheological properties, miscibility, and biocompatibility is essential to optimize drug release. This work presents a computational study of the effect of the basic formulation factors on the characteristics of the obtained in situ-forming particulates (IFPs) encapsulating a model drug using a 21.31 full factorial experimental design. The emulsion method was employed for the preparation of lipid and/or polymer-based IFPs. The IFP release profiles and parameters were computed. Additionally, a desirability study was carried out to choose the optimum formulation for further morphological examination, rheological study, and PBPK physiological modeling. Results revealed that the type of particulate forming agent (lipid/polymer) and the incorporation of structure additives like Brij 52 and Eudragit RL can effectively augment the release profile as well as the burst of the drug. The optimized formulation exhibited a pseudoplastic rheological behavior and yielded uniformly spherical-shaped dense particulates with a PS of 573.92 ± 23.5 nm upon injection. Physiological modeling simulation revealed the pioneer pharmacokinetic properties of the optimized formulation compared to the observed data. These results assure the importance of controlling the formulation factors during drug development, the potentiality of the optimized IFPs for the intramuscular delivery of piroxicam, and the reliability of PBPK physiological modeling in predicting the biological performance of new formulations with effective cost management.

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Biometric characteristics of the lacrimal passages in healthy individuals and in patients with nasolacrimal duct obstruction

Atkova,

Yartsev,

Ekaterinchev

et al. 2023

Vestn. oftal'mol.

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Rheological Behavior Patterns in Artificial Tears

Cited by 3 publications

References 16 publications

Surface Chemistry Study of Normal and Diseased Human Meibum Films Prior to and after Supplementation with Tear Mimetic Eyedrop Formulation

Surface Chemistry Study of Normal and Diseased Human Meibum Films Prior to and after Supplementation with Tear Mimetic Eyedrop Formulation

Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of Experiment and PBPK Physiological Modeling

Biometric characteristics of the lacrimal passages in healthy individuals and in patients with nasolacrimal duct obstruction

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