Rheological assessment of mucolytic agents on sputum of chronic bronchitics

Dippy, J. E.; Davis, S.S.

doi:10.1136/thx.24.6.707

Cited by 20 publications

(14 citation statements)

References 27 publications

(19 reference statements)

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“…Mild gastrointestinal symptoms are the most common side effects [21] however, when used as a mucolytic agent it has been reported to cause local irritation [71] .…”

Section: Safety and Tolerability Of Nacmentioning

confidence: 99%

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

Dodd

Dean

Copolov

et al. 2008

Expert Opinion on Biological Therapy

369

212

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Background : Glutathione is an endogenous antioxidant and has a ubiquitous role in many of the body's defences. Treatment with N -acetylcysteine (NAC) has been shown to increase levels of glutathione. NAC has been proposed as a treatment for several illnesses. Objectives : The efficacy and tolerability of NAC was examined across a range of conditions to evaluate the evidence supporting the use of NAC for each indication. Methods : A literature search was conducted using PubMed. Information was also collected from other online sources including the websites of the Therapeutic Goods Administration of Australia and the FDA. Results : Reports ranged from case studies to clinical trials. There is strong evidence to support the use of NAC for the treatment of paracetamol overdose and emerging evidence suggesting it has utility in psychiatric disorders, particularly schizophrenia and bipolar disorder. NAC is safe and well tolerated when administered orally but has documented risks with intravenous administration.

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“…Mild gastrointestinal symptoms are the most common side effects [21] however, when used as a mucolytic agent it has been reported to cause local irritation [71] .…”

Section: Safety and Tolerability Of Nacmentioning

confidence: 99%

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

Dodd

Dean

Copolov

et al. 2008

Expert Opinion on Biological Therapy

369

212

View full text Add to dashboard Cite

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“…In all cases, the standard deviations about the mean are large due to considerable biological variation. Nevertheless, statistical analysis (16) shows that the results are valid and can be used in a comparative manner. The agreement between the two methods, balance and FerrantiShirley viscometer, is extremely satisfactory, especially when one considers that two different measurement principles are used.…”

Section: Comparison Of Balance Methods With Ferranti-shirley Viscometermentioning

confidence: 99%

“…In these cases, the linear viscoelastic model was employed as a convenient starting point and the experimental results were interpreted in terms of viscosities, elasticities, and relaxation or retardation times. In some cases, such as the assessment of mucolytic agents or the routine examination of clinical samples in the clinical laboratory, a detailed viscoelastic treatment is time consuming and probably unnecessary (16). It would rarely warrant the considerable capital outlay needed for setting up the experimental and data analysis procedures.…”

mentioning

confidence: 99%

Chemical Balance as a Rheometer for Biological Fluids

Davis

Warburton

Dippy

1970

Journal of Pharmaceutical Sciences

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“…MEASUREMENT OF SPUTUM viscosrrY The theoretical aspects of measurement of sputum viscosity have been well described (Blanshard, 1955;Wells, Denton, and Merrill, 1961;Dippy and Davis, 1969). Sturgess (1969) has recently described the examination of the properties of CF sputum by means of a Ferranti-Shirley cone and plate viscometer.…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis

Feather¹,

Russell²

1970

Thorax

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Comparisons have been made between the effects of autonomic dysfunction and the pathophysiological changes in the exocrine secretions from patients with cystic fibrosis (Roberts, 1959). Cotton (1966) found that administration of tolazoline hydrochloride (an alpha-adrenergic blocker) to patients with cor pulmonale in the terminal stages of cystic fibrosis was associated with an improvement in the results of their lung function tests. This effect might have been due to an alteration of the abnormal viscosity of the bronchial mucus mediated via the autonomic nervous system, thus permitting easier expectoration. Measurement, by means of a Ferranti-Shirley cone and plate viscometer, of several different aspects of sputum viscosity is described. Tolazoline hydrochloride, administered to five patients with cystic fibrosis, was shown not to differ significantly from a placebo in its effect on sputum viscosity and dynamic lung volumes. We could not relate the improved lung function seen in Cotton's series to an autonomic effect of the drug on the physical properties of bronchial mucus in this condition.

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Rheological assessment of mucolytic agents on sputum of chronic bronchitics

Cited by 20 publications

References 27 publications

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

Chemical Balance as a Rheometer for Biological Fluids

Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis

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