Rheologic behavior of sickle and normal red blood cell mixtures in sickle plasma: implications for transfusion therapy

Abstract

These results indicate the importance of plasma-mediated RBC interactions and suggest that the benefits of transfusion may vary depending on local flow rates (i.e., shear rates) and organ-specific hemodynamics.

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

“…Although some hemorheological parameters differed between SCC and SCA patients, both have markedly reduced and essentially identical HVR levels at all shear rates ( Figure 1); our calculated mean HVR values are consistent with the range reported by Serjeant et al 29 Thus the oxygen transport effectiveness of blood in SCA and SCC subjects is lower than in controls, a finding also seen in other disease states. 6 Recent results obtained by Alexy et al 8 also support our findings. They investigated HVR in mixtures of AA and SCA RBC and found that HVR decreased as the proportion of HbS increased; due to the non-Newtonian, shear-thinning flow behavior of blood, HVR also decreased as shear rate decreased.…”

“…Our results indicating that HVR depends on shear rate confirm this prior report. 8 Note that HVR was not decreased in sickle cell trait carriers, and thus AA and AS groups have nearly identical HVR values ( Figure 1). Although AS subjects have elevated blood viscosity as for SCC patients, the hemorheological oxygen transport potential seems to be well preserved in sickle cell trait.…”

“…[5][6][7] In a recent study, Alexy et al described impaired HVR in patients with SCA and suggest that the reduced HVR might play a role in the pathophysiology of the disease. 8 Unfortunately, similar studies are lacking for patients with SCC and sickle cell trait (AS).…”

Incidence of alloimunization in sickle cell disease: experience of a center in São Paulo

“…This small change in the structure of the chain is responsible for deep changes in the stability of the molecule and in its solubility. Such change is capable of causing polymerization of hemoglobin chains when its deoxygenation occurs (2,3) . In the 1930´s, the role of blood transfusions to treat pain crises and manage vessel-occlusive phenomena was acknowledged (3,4) .…”

“…Such change is capable of causing polymerization of hemoglobin chains when its deoxygenation occurs (2,3) . In the 1930´s, the role of blood transfusions to treat pain crises and manage vessel-occlusive phenomena was acknowledged (3,4) . Blood transfusions have been important to treat stroke patients and for the prophylaxis of new ischemic events (4,5) .…”