Rhenium Sulfide Nanoparticles as a Biosafe Spectral CT Contrast Agent for Gastrointestinal Tract Imaging and Tumor Theranostics in Vivo

Wang, Xiaoyi; Wang, Jiaojiao; Pan, Jinbin; Zhao, Fangshi; Kan, Di; Cheng, Ran; Zhang, Xuening; Sun, Shao‐Kai

doi:10.1021/acsami.9b10479

Cited by 47 publications

(39 citation statements)

References 65 publications

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“…Nanoparticles, generally characterized by submicronic (<1 µm) systems of metallic or organic materials, offer broad applications in various fields including tumor detection, imaging, diagnosis and treatment 56 . Several types of nanoparticles, such as carbonaceous, Prussian blue, or paramagnetic nanoparticles are available for in vitro diagnosis based on their peroxidase-like activity or function as enzyme carriers 57 , 58 and in vivo diagnosis as carriers of contrast agents 59 , 60 . In addition to diagnosis, their current applications in cancer treatment have gained widespread interest.…”

Section: Discussionmentioning

confidence: 99%

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype

Liu¹,

Xu²,

Li³

et al. 2021

Int. J. Med. Sci.

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Background: Regulating the polarization of macrophages to antitumor M1 macrophages is a promising strategy for overcoming the immunosuppression of the tumor microenvironment for cancer therapy. Ferumoxytol (FMT) can not only serve as a drug deliver agent but also exerts anti-tumor activity. β-glucan has immuno-modulating properties to prevent tumor growth. Thus, a nanocomposite of FMT surface-coated with β-glucan (FMT-β-glucan) was prepared to explore its effect on tumor suppression. Methods:Male B16F10 melanoma mouse model was established to explore the antitumor effect of FMT-β-glucan. The viability and apoptotic rates of B16F10 cells were detected by cell counting kit-8 and Annexin-V/PI experiments. The levels of M1 markers were quantified by quantitative reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay. Phagocytic activity and intracellular reactive oxygen species (ROS) in macrophages were evaluated by the neutral red uptake assay and flow cytometry, respectively. Small interfering RNA (siRNA) transfection was applied to knock down the Dectin-1 gene in RAW 264.7 cells.Results: FMT-β-glucan suppressed tumor growth to a greater extent and induced higher infiltration of M1 macrophages than the combination of FMT and β-glucan (FMT+β-glucan) in vivo. In vitro, supernatant from FMT-β-glucan-treated RAW 264.7 cells led to lower cell viability and induced more apoptosis of B16F10 cells than that from the FMT+β-glucan group. Moreover, FMT-β-glucan boosted the expression of M1 type markers, and increased phagocytic activity and ROS in RAW 264.7 cells. Further research indicated that FMT-β-glucan treatment promoted the level of Dectin-1 on the surface of RAW 264.7 cells and that knockdown of Dectin-1 abrogated the phosphorylation levels of several components in MAPK and NF-κB signaling. Conclusion:The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype

Liu¹,

Xu²,

Li³

et al. 2021

Int. J. Med. Sci.

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“…Mortezazadeh confirmed in vitro cell experiments that nanocontrast agents can improve MR imaging quality without increasing cytotoxicity [20]. Some other researches have stated that the signal-to-noise ratio of rhenium sulfide nanoparticle contrast agent is higher than that of iodine contrast agent, and the use of rhenium sulfide nanoparticle contrast agent in CT imaging can improve the contrast of gastrointestinal imaging in patients [21]. At present, the common CTA nanocontrast agents include nano suspensions, micelles, and nano latexes [22][23][24].…”

Section: Discussionmentioning

confidence: 88%

The Value of CTA Based on Gold Nanorod Contrast Agent in Coronary Artery Diagnosis and Plaque Property Analysis

Wang

et al. 2021

Computational and Mathematical Methods in Medicine

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Coronary CT angiography (CTA) with the characteristics of noninvasive and simple operation is widely used in the diagnosis of coronary artery stenosis. The choice of contrast agent exerts an important impact on the imaging quality of CTA. Conventional iodine contrast agents are easily excreted by the kidneys, from which the imaging window is short, and the imaging quality is poor. Metal nanomaterials have unique optical properties and have broad application prospects in imaging. Our aim is to explore the value of gold nanorod contrast agent in the diagnosis of coronary heart disease. A gold nanorod suspension was first prepared, and the prepared gold nanorod was uniform and had good dispersibility. It can be seen from the light absorption curve that there are two obvious peaks on the UV absorption peak of the gold nanorods. The gold nanorods were cultured in different solutions, and it was found that the particle size of the gold nanorods did not change significantly within 72 hours, indicating that the prepared gold nanorods had good stability. When observing the damage degree of mouse kidney tissue, it was shown that the damage degree of gold nanorod contrast agent to mouse kidney tissue was less than that of iodine contrast agent. The above results indicate that the gold nanorod contrast agent has good stability and safety. Therefore, our study demonstrated that the gold nanorod contrast agent has high value in the diagnosis of coronary arteries and the analysis of plaque properties.

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“…For example, when using iodine contrast agents, patients need to use nephrotoxic drugs, mannitol, diuretics, and other drugs for the disease. Wang et al confirmed in his research that the signal-to-noise ratio of iodine contrast agent is relatively poor, and there are certain biological safety risks [22]. Therefore, finding new and effective CT contrast agents has become the focus of research by many scholars and clinicians.…”

Section: Analysis Of Consistency Between Ct and Postoperativementioning

confidence: 99%

Correlation between Imaging Features and Pathological Stages of Primary Lung Tumors Based on Nanocontrast Agents

Li¹,

Qian²,

Mao

et al. 2021

Computational and Mathematical Methods in Medicine

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As one of the conventional methods of lung cancer detection, computed tomography (CT) usually requires the use of contrast agents to enhance the imaging effect. Conventional iodine contrast agents have poor signal-to-noise ratio and are prone to adverse reactions. It is necessary to find more effective and safe contrast agents for CT scans. The gold nanoparticles with secondary electron effect and photoelectric absorption effect can prolong the display time of the patient’s blood circulation after being injected into the patient’s body, which makes the nanocontrast agent a research hotspot in the field of CT imaging. In this study, ultrasmall gold nanoclusters with a diameter of about 5 nm were used as the contrast agent in CT scans. It was found that CT scans based on nanocontrast agents can obtain high-quality lung cancer imaging images, and the patient has no obvious adverse reactions. When observing the CT image, it was found that the stage of lung cancer patients can be clearly distinguished through the CT scan image. When analyzing the consistency of CT imaging and pathological classification, the Kappa value was 0.810, indicating that the two have a high degree of consistency. Therefore, this study believes that the imaging characteristics of primary lung tumors based on nanocontrast agents are highly correlated with their pathological types.

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Rhenium Sulfide Nanoparticles as a Biosafe Spectral CT Contrast Agent for Gastrointestinal Tract Imaging and Tumor Theranostics in Vivo

Cited by 47 publications

References 65 publications

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype

Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype

The Value of CTA Based on Gold Nanorod Contrast Agent in Coronary Artery Diagnosis and Plaque Property Analysis

Correlation between Imaging Features and Pathological Stages of Primary Lung Tumors Based on Nanocontrast Agents

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