Rhenium(I)-tricarbonyl complexes with methimazole and its selenium analogue: Syntheses, characterization and cell toxicity

Rhenium fac-Tricarbonyl Bisimine Chalcogenide Complexes: Synthesis, Photophysical Studies, and Confocal and Time-Resolved Cell Microscopy

“…In the past few years, we have explored the impact of structural modifications and decoration of rhenium carbonyl complexes on their photophysical properties and on their penetration and subcellular distribution. ,,, We have exploited these complexes in correlative fluorescence and infrared imaging studies and more recently developed such complexes as organelle-targeting probes suitable for XRF mapping. ,,,, The most explored ancillary ligands X are halogen, O, N, or P donor-based ligands and much is known about their electronic structures and properties. Sulfur-based X ligands have received interest more recently, with substituted benzenethiolates, , mercaptopyridines, − cysteine and derivatives, thiosulfate, and methimazole as prominent examples. The corresponding complexes were investigated in structural studies or for their photophysical properties, cellular localization using XRF imaging, and cytotoxicity.…”

“…16,17,20,37,38 The most explored ancillary ligands X are halogen, O, N, or P donor-based ligands and much is known about their electronic structures and properties. Sulfur-based X ligands have received interest more recently, with substituted benzenethiolates, 36,39 mercaptopyridines, 40−42 cysteine and derivatives, 43 thiosulfate, 44 and methimazole 45 as prominent examples. The corresponding complexes were investigated in structural studies or for their photophysical properties, cellular localization using XRF imaging, and cytotoxicity.…”

“…36 We extend our previous work here with the benzeneselenolate corresponding complexes and their photophysical characterizations. Cationic complexes with 1-methylimidazole-2-selone (N∧N = bpy, phen, dmphen) were published this year, 45 and a Re(I)-diselenoether (Re-diSe) was shown to display promising anticancer properties. 46,47 The complexes described here are, to the best of our knowledge, the first neutral diimine bearing complexes with a seleniumbased axial ligand.…”

Tricarbonyl rhenium(i) complexes with 8-hydroxyquinolines: structural, chemical, antibacterial, and anticancer characteristics

“…[18][19][20][21][22][23][24][25][26] Several investigations showed the potential anticancer activity of Re(CO) 3 , better than used Pt-drugs, as well as their signicant antimicrobial effects. [27][28][29][30][31][32][33] On the other hand, 8hydroxyquinoline and its derivatives are popular organic compounds used as medicines, e.g., clioquinol (5-chloro-8hydroxy-7-iodoquinoline) exhibits antibacterial and antifungal activity and is used for the treatment of skin infections; nitroxoline (8-hydroxy-5-nitroquinoline) is an antibacterial and anticancer drug; and iodoquinol (5,7-diiodo-8hydroxyquinoline) is effective in the treatment of amebiasis. 34,35 Only 16 crystal structures of tricarbonyl rhenium(I) complexes with 8-hydroxyquinolinato ligands have been reported and structurally characterized in the Cambridge Structural Database (CSD, version 5.45).…”