Rhenium-188 Mercaptoacetyltriglycine–filled Balloon Dilation in the Treatment of Recurrent Urethral Strictures: Initial Experience with Five Patients

Shin, Ji Hoon; Song, Ho-Young; Moon, Dae Hyuk; Oh, Seungjun; Kim, Tae-Hyung; Lim, Jin-Oh

doi:10.1097/01.rvi.0000235738.28095.04

Cited by 9 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, rhenium-188 mercaptoacetyltriglycine-filled balloon dilation is expected to delay stricture recurrence in patients with urethral strictures. A clinical report of five patients revealed that the mean treatment interval was prolonged from 2.2 months to 10.7 months after rhenium-188 mercaptoacetyltriglycine-filled balloon dilation 57. Further consideration needs to be given to factors such as the local drug concentration achievable in dilation and the reliability of the therapeutic dose.…”

Section: Discussionmentioning

confidence: 99%

“…A clinical report of five patients revealed that the mean treatment interval was prolonged from 2.2 months to 10.7 months after rhenium-188 mercaptoacetyltriglycine-filled balloon dilation. 57 Further consideration needs to be given to factors such as the local drug concentration achievable in dilation and the reliability of the therapeutic dose. The design of new balloons, such as cutting balloons, and the exploration of new expansion techniques may be research directions in the future.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis

Li,

Xu,

et al. 2024

BMJ Open

View full text Add to dashboard Cite

ObjectiveThe use of minimally invasive endoluminal treatment for urethral strictures has been a subject for debate for several decades. The aim of this study was to review and discuss the safety, efficacy and factors influencing the clinical application of balloon dilation for the treatment of male urethral strictures.DesignSystematic review and meta-analysis.Data sourcesEmbase, Medline, Web of Science, Cochrane Library and Scopus were searched for publications published before 17 July 2022.Study selectionTwo independent researchers screened and assessed the results, and all clinical studies on balloon dilation for the treatment of urethral strictures in men were included.Data extraction and synthesisThe success rate, rate of adverse events, International Prostate Symptom Scores, maximum uroflow (Qmax) and postvoid residual urine volume were the main outcomes. Stata V.14.0 was used for statistical analysis.ResultsFifteen studies with 715 patients were ultimately included in this systematic review. The pooled results of eight studies showed that the reported success rate of simple balloon dilation for male urethral strictures was 67.07% (95% confidence interval [CI]: 55.92% to 77.36%). The maximum urinary flow rate at 3 months (risk ratio [RR]= 2.6510, 95% CI: 1.0681 to 4.2338, p<0.01) and the maximum urinary flow rate at 1 year (RR= 1.6637, 95% CI: 1.1837 to 2.1437, p<0.05) were significantly different after dilation. There is insufficient evidence to suggest that balloon dilation is superior to optical internal urethrotomy or direct visual internal urethrotomy (DVIU) (RR= 1.4754, 95% CI: 0.7306 to 2.9793, p=0.278).ConclusionBalloon dilation may be an intermediate step before urethroplasty and is a promising alternative therapy to simple dilation and DVIU. The balloon is a promising drug delivery tool, and paclitaxel drug-coated balloon dilation is effective in reducing retreatment rates in patients with recurrent anterior urethral strictures. The aetiology, location, length, previous treatment of urethral stricture may be associated with the efficacy of balloon dilation.PROSPERO registration numberCRD42022334403.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis

Li,

Xu,

et al. 2024

BMJ Open

View full text Add to dashboard Cite

show abstract

“…Mitomycin C has been largely used due to its anti-collagen property to minimize the recurrence rate of stricture after internal optical urethrotomy. Urethral stricture recurred in only 10% of patients at 6 months follow-up duration [14]. Hardec and team used corticosteroid injections in combination with internal optical urethrotomy and the result was a decrease in recurrence rate [15].…”

Section: Discussionmentioning

confidence: 99%

Outcome of Internal Optical Urethrotomy in Combination with Corticosteroids Injection in Recurrent Anterior Urethral Strictures

RA,

2022

austinjurol

View full text Add to dashboard Cite

Background: Urethral stricture is a common urological disease and can occur mostly as a result of recurrent infections, inflammation, trauma or unknown factors. Internal optical urethrotomy is a useful treatment modality for the management of urethral strictures. Several adjuvant interventions are suggested to decrease the recurrence rate of urethral strictures. Objectives: To report the success rate of internal optical urethrotomy in combination with corticosteroids in recurrent anterior urethral strictures. Materials and Methods: This prospective clinical randomized control trial was performed on 70 patients from 1st January 2017 to 31st Dec 2018. Patients fulfilling the inclusion criterion were randomly divided into two groups. The experimental group comprises 34 patients who received a corticosteroid injection in combination with internal optical urethrotomy while the control group consisting of 36 patients who received distilled water in combination with internal optical urethrotomy. All the patients were advised not to do clean intermittent self-catheterization (CISC) and were followed for 24 months. Results: The mean follow-up time was 9 ± 5.40 months (6-24 months). Complications occurred in 14 patients. In the experimental group recurrence of stricture occurred in 11 patients, extravasation into perispongeal space in 3 patients (8.82%), infection in 1(2.94%) and bleeding in 2(5.8%) patients. In the control group recurrence of stricture occurred in 16 patients, Infection occurred in 3 patients and extravasation and bleedings in 2 and 3 patients respectively. Moreover, the difference between the recurrence in the experimental and control groups is also not significant (p.0.05). However, the stricture-free duration that is the time of recurrence was significantly delayed in the experimental group (8.07 ± 5.51 versus 3.8 ± 1.53 months). Conclusion: It is concluded that internal optical urethrotomy in combination with corticosteroid injection delays the recurrence rate of urethral stricture significantly. It can also be a feasible procedure for those who do not want urethroplasty or those with high risk for general anesthesia.

show abstract

“…Like the small series reported by Sun et al [31], the results were not reported according to stricture location, stricture etiology, or other defining characteristics, except for length, making interpretation of the results very problematic. In 2006, Shin et al [33] reported their experience with rhenium-188 mercaptoacetyltriglycine (188Re-MAG3)-filled balloon dilation for recurrent bulbar urethral strictures in four men. The stricture was balloon dilated using a conventional coaxial dilator or a OIU/DVIU was performed if the stricture could not be balloon dilated effectively, followed immediately by placement of the 188Re-MAG3-filled balloon dilator for nearly 10 minutes (dose of 20-30 Gray units [Gy]; tissue depth, 1 mm).…”

Section: Endoscopic Internal Urethrotomymentioning

confidence: 99%

Minimally invasive treatment of urethral strictures in men

Latini

2008

Curr Bladder Dysfunct Rep

View full text Add to dashboard Cite

Rhenium-188 Mercaptoacetyltriglycine–filled Balloon Dilation in the Treatment of Recurrent Urethral Strictures: Initial Experience with Five Patients

Cited by 9 publications

References 20 publications

Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis

Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis

Outcome of Internal Optical Urethrotomy in Combination with Corticosteroids Injection in Recurrent Anterior Urethral Strictures

Minimally invasive treatment of urethral strictures in men

Contact Info

Product

Resources

About